The Effect of Conscious Sedation on Salivary Alpha-Amylase Levels During Third Molar Surgery

Abdullah Tolga Şitilci 1, Selin Gaş 2 * , Şule Batu 3, Hümeyra Kocaelli Arıkan 4, Büşra Bozbay 5
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1 Department of Anesthesiology and Reanimation, School of Dentistry, Istanbul University, Istanbul, Turkey
2 Department of Oral and Maxillofacial Surgery, School of Dentistry, Beykent University, Istanbul, Turkey
3 Biochemistry Department, School of Dentistry, Istanbul University, Istanbul, Turkey
4 Oral and Maxillofacial Surgery Department, School of Dentistry, Istanbul University, Istanbul, Turkey
5 Orthodontics Department, School of Dentistry, La Sapienze University, Rome, Italy
* Corresponding Author
J CLIN MED KAZ, Volume 2, Issue 56, pp. 11-16. https://doi.org/10.23950/1812-2892-JCMK-00738
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ABSTRACT

Aim: The aim of the present study was to investigate whether salivary alpha-amylase levels could be decreased by conscious sedation in the patients undergoing impacted third molar extraction.
Material and methods: A total of 18 male patients were recruited. All patients were administered the Modified Dental Anxiety Scale test. Patients were divided into a test group (procedures under sedation) and a control group (procedures under local anesthesia). Systolic blood pressure, diastolic blood pressure, oxygen saturation, and heart rate were monitored at different study time-points. Five samples of saliva were taken from each patient: the first time the patient came to the clinic, the patient sat in the chair for extraction, before local anesthesia, immediately after extraction, at 4 h after extraction.
Results: Although no statistically important difference was found for systolic blood pressure (p>0.05) between groups, postoperative diastolic blood pressure level of control group was statistically higher than the test group (p=0.030). Also, a statistically significant decrease was found in the oxygen saturation level in postoperative time compared to preoperative time (p<0.05). 
Conclusion: Even though conscious sedation may be a solution for dental anxiety and phobia, our results indicated that sedation did not affect acute stress levels during oral surgery.
Keywords: conscious sedation, dental anxiety, stress biomarkers, salivary alpha-amylase, tooth extraction

CITATION

Şitilci AT, Gaş S, Batu Ş, Kocaelli Arıkan H, Bozbay B. The Effect of Conscious Sedation on Salivary Alpha-Amylase Levels During Third Molar Surgery. Journal of Clinical Medicine of Kazakhstan. 2020;2(56):11-6. https://doi.org/10.23950/1812-2892-JCMK-00738

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