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Abstract - Results of Prospective Analysis of the Antibiotic Susceptibility of Streptococcus Pneumoniae Strains Isolated From Patients with Progressive Respiratory Infections
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Nelya Bissenova, Aigerim Yergaliyeva

The aim of this study was to analyses the antibiotic susceptibility of Streptococcus pneumoniae strains isolated from patients with progressive respiratory infections.

Methods.  Sputum of hospitalized patients diagnosed with progressive respiratory infection during 2009-2013 was included to the prospective bacteriological study. Initial seeding material conducted a quantitative method on nutrient medium according to guidelines. The identification of isolates and antibiotic susceptibility testing were performed by microbiological analyzer Microtax, MiniApi, Vitek 2-Compact. The etiological factor was defined at a concentration of 106 and above. The results were subjected to statistical analysis. We determined averages, an averages error (m), Students test, a confidence interval (p). The probability of null hypothesis did not exceed 0.05 (p<0.05).

Results. Streptococcus pneumoniae was the most frequently isolated from sputum with progressive respiratory infection. Antibiotic susceptibility testing showed that Streptococcus pneumoniae had 100% susceptibility to vancomycin. The susceptibility to beta-lactams ranged from 56.6% to penicillin up to 80.1% to cefuroxime. The most activity from quinolones was levofloxacin – 82.6% susceptibility strains of Streptococcus pneumoniae. Macrolides showed susceptibility rate below 50%.

Conclusions. 1) Streptococcus pneumoniae had 100% susceptibility to vancomycin. 2) The susceptibility of Streptococcus pneumoniae was above 80% to levofloxacin, cefuroxime, ceftriaxone.

Volume 2, Number 32 (2014)