Estimation of parameters of connective tissue metabolism at bronchoobstruction progression in patients with chronic obstructive pulmonary disease and concomitant arterial hypertension

Оценка показателей метаболизма соединительной ткани по мере прогрессирования бронхообструкции у больных хроническим обструктивным заболеванием легких и сопутствующей артериальной гипертензией
Valentina Delevskaya 1
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1 Kharkiv National Medical University, Kharkov, Ukraine
J CLIN MED KAZ, Volume 4, Issue 34, pp. 34-39.
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ABSTRACT

The aim: To study the changes in connective tissue metabolism at progression of bronchoobstruction in patients with chronic obstructive pulmonary disease in combination with arterial hypertension and to determine the character of their correlations with parameters of respiratory function.
Methods: We investigated the level of serum chondroitin sulfates, glycoproteins, glycosaminoglycans and their fractional composition in 62 patients with chronic obstructive pulmonary disease of II and III degree of severity of airflow limitation with concomitant arterial hypertension.
Results: The patients had elevated serum levels of chondroitin sulfates, chondroitin-6-sulfates, glycoproteins and reduced levels of dermatan / chondroitin-4-sulfates and keratan- / heparan sulphates. While progression from II to III degree of severity of airflow limitation, along with increased levels of glycoproteins the patients had chondroitin-6-sulfates and chondroitin-4-sulfates increase and heparan sulphate decrease, that may indicate impaired synthesis of the latter type of glycosaminoglycans and expressed extracellular matrix degradation processes. Study revealed moderate and strong correlations between parameters of respiratory function, chondroitin-6-sulfates, heparan sulfates and glycoproteins may indicate their involvement in the pathogenesis of bronchial obstruction in chronic obstructive pulmonary disease and arterial hypertension.
Conclusion: Serum levels of chondroitin-6-sulfates, glycoproteins and heparan sulfates may be used in predicting bronchoobstruction progression in patients with chronic obstructive pulmonary disease and arterial hypertension.
Keywords: heparan sulphates, chondroitin-6-sulfates, chondroitin-4-sulfates, glycosaminoglycans, bronchial obstruction, arterial hypertension

CITATION

Delevskaya V. Estimation of parameters of connective tissue metabolism at bronchoobstruction progression in patients with chronic obstructive pulmonary disease and concomitant arterial hypertension. Journal of Clinical Medicine of Kazakhstan. 2014;4(34):34-9.

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