The role of regulatory autoantibodies in prediction of obstetric hemorrhage

Роль определения регуляторных аутоантител в прогнозировании акушерских кровотечений
Gauri Bapayeva 1, Saltanat Kulbayeva 2
More Detail
1 National Research Center for Maternal and Child Health, Astana, Kazakhstan
2 South Kazakhstan State Pharmaceutical Academy, Shymkent, Kazakhstan
J CLIN MED KAZ, Volume 1, Issue 35, pp. 34-39.
OPEN ACCESS 3099 Views 2201 Downloads
Download Full Text (PDF)

ABSTRACT

The aim: to evaluate the prognostic valueof regulatory autoantibodies for prediction of obstetric hemorrhage
Materials and methods:126 pregnant women have been examined, i.e. 96 pregnant women of haemorrhage risk group and 30 pregnant women with physiologic gestation and childbirth course. Pregnant women of risk group have been divided into 2 groups depending on outcome of childbirth: basic and comparative groups. Basic group included 65 women, who had postpartum haemorrhageand comparative group included 31 women of risk group without postpartum haemorrhage. The level of regulatory autoantibodies in blood serum of all pregnant women was determined in 3rd trimester of pregnancy using the enzyme-linked immunosorbent assay technology.
Results: The greatest predictive importance definition of the regulatory possesses autoantibodies to DNA, TrM-03 and ANCA, and also average immunological reactivity (transgression coefficient – 44,64%, 11,86%, 14,41% and 40,51% respectively).
Conclusion:Thedeterminationof regulatory autoantibodiesin the bloodof pregnant womenin the 3rdtrimester has high predictive value(82%).

CITATION

Bapayeva G, Kulbayeva S. The role of regulatory autoantibodies in prediction of obstetric hemorrhage. Journal of Clinical Medicine of Kazakhstan. 2015;1(35):34-9.

REFERENCES

  • Kudajbergenov T.K., Biktasheva H.M. Analiz materinskoj smertnosti beremennyh, rozhenicirodil’nic (Analysis of maternal mortality of pregnant women, women in labor and postpartum women), Almaty, 2011, pp. 54-121.
  • Togyzbaeva K.T., Bapaeva G.B. Perinatal’nye ishody u mnogorozhavshih zhenshhin (Perinatal outcomes in multiparous women), Zdorov’eibolezn’, 2009, No.7(83), pp.96 – 99.
  • Bapaeva G.B., Kulbaeva S.N., Kerimbaeva Z.A. Problemy akusherskih krovotechenij u mnogorozhavshih zhenshhin (Obstetric haemorrhagein multiparous women, Densaulyк saкtaudy damytu zhurnaly, 2012, No.3(64), pp.100-105.
  • Bapaeva G., An Z., BacciA., Osnovnye prichiny materinskoj smertnosti v akusherskoj praktike: pervyj opyt i itogi konfidencial’nogo audita v Respublike Kazahstan (The basic reasons of maternal mortality in obstetrical practice: the first experience and results of confidential audit in Republic of Kazakstan), Entre Nous, 2011, No.74, pp. 16-17.
  • Kudajbergenov T.K., Biktasheva H.M. Analiz materinskoj smertnosti beremennyh, rozhenicirodil’nic (Analysis of maternal mortality of pregnant women, women in labor and postpartum women), Almaty, 2013, pp. 23-87.
  • Kajupova N.A. Profilaktika akusherskih oslozhnenij u beremennyh gruppy riska (Prevention of obstetric complications in pregnant women of risk group): avtoref. diss…. dok. med. nauk, Almaty, 1988. 45 p.
  • Oyelese Y., Scorza W.E., Mastrolia R., Smulian J.C. Postpartum hemorrhage, Obstet. Gynecol. Clin. N. Am, 2007, Vol. 34, No. 3, pp. 421–441.
  • Bazylbekova Z.O. Prognozirovanie I profilaktika akusherskih krovotechenij v gruppah riska (Prediction and prevention of obstetric hemorrhagein risk group), avtoref. diss…. dok. med. nauk, Almaty, 2002. 28 p.
  • Bapaeva G.B., Kulbaeva S.N. Prognozirovanie poslerodovyh krovotechenij u mnogorozhavshih zhenshhin (Prediction of postpartum haemorrhage in multiparouswomen), Akusherstvo, ginekologija I perinatologija, 2012. No.4, pp. 12-14.
  • Njuhnin M.A. Klinicheskoe znachenie ocenki soderzhanija estestvennyh autoantitel dlja optimizacii taktiki beremennyh s otjagoshhennym akusherskim anamnezom: (Clinical significance of natural autoantibodies content for optimization of approach to the pregnant women with aggravated obstetrical anamnesis), avtoref. diss. … kan.med. nauk, Kazan, 2007, 24p.
  • Lee R.M.,Brown M.А., Brаnch D.W. et аl. Аnticаrdiolipin аnd аnti-betа2-glycoprotein-I аntibodies in preeclаmpsiа, Obstet. Gynecol, 2003, No.102(2), pp.294-300.
  • Cherepanova N.A. Klinicheskoe znachenie urovnej reguljatornyh autoantitel dlja ocenki riska razvitija gestoza (Clinical significance of regulatory autoantibodies for risk evaluation of gestosis), avtoref. diss. … kan. med. nauk. Kazan, 2008, 24p.
  • Bowen R.S., Moodley J., Dutton M.F., Fickl H. Аntibodies to oxidised low-density lipoproteins аnd cаrdiolipin in preeclаmpsiа аnd eclаmpsiа, J. Obstet. Gynаecol, 2002, No.22(2), pp. 123-126.
  • Bukatina S.V. Klinicheskoe znachenie izmenenija urovnja reguljatornyh autoantitel dlja ocenki riska razvitija krovotechenij v rodah i poslerodovom periode (Clinical value of change of regulatory autoantibodies level for evaluation of haemorrhages risk during childbirth and postpartum period), avtoref. diss… kan. med. nauk, Kazan, 2011. 127 p.
  • PoletаevА.,Osipenko L. Generаl network of nаturаl аutoаntibodiesаs Immunologicаl Homunculus (Immunculus), Аutoimmunity Review, 2003, No.2 (5), pp.264-271.
  • Poletaev A.B. Molekuljarnaja dispanserizacija (Novye podhody k rannemu vyjavleniju patologicheskih izmenenij v organizme cheloveka) Vvedenie v teoriju i Metodicheskie rekomendaci dlja vrachej (Molecular-based health survey (New approaches to the early definition of pathologic changes in human body)), Moscow, 2013, 43 p.
  • Gubler E.V., Genkin A.A. Primenenie neparametricheskih kriteriev statistiki v mediko-biologicheskih issledovanijah (The use ofnonparametricstatistics inbiomedical research) Leningrad, Medicina, 1973, pp. 121 - 141.
  • Lakin G.F. Biometrija (Biometry), Moscow, 1990, pp.150-153.
  • Kulbaeva S. Osobennosti izmenenija urovnja reguljatornyh autoantitel pri akusherskih krovotechenijah v zavisimosti ot pariteta rodov (Changes in the levelof regulatory autoantibodies in obstetric haemorrhage depending on childbirths parity), avtoref. diss… na soiskanie uchenoj stepeni doktora filosofii (PhD),.Turkestan, 2014, 21 p.