Online ISSN 2313-1519
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Abstract - Analysis of intestinal disbiosis in adult patients
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Nelya Bissenova, Aigerim Yergaliyeva

The aim of this study: to compare microbiologic indicators of intestinal microbiocenosis of patients after acute intestinal infections in patients with chronic diseases of the digestive tract.

Materials and methods. This is prospective bacteriological study, included 76 patients (40 men and 36 women). The first group consisted of outpatients who for 1-3 months before this study suffered an acute intestinal infection of bacterial etiology (n = 37). The second group consisted of 25 patients from the Department of Therapy diagnosed with chronic pancreatitis. The third group consisted of 14 patients from the Department of Transplantation diagnosed with liver fibrosis.

Results. The deficit amount of content obligate microflora was most pronounced in patients with acute intestinal infection transferred. In 91.8% of the group surveyed the number of lactobacilli was below normal. 51.3% of patients had a reduced content of E. coli with normal enzymatic activity, at 43.2% defined quantitative reduction of bifidobacteria and 48.6% lack of enterococci. The biggest change from the facultative intestinal microflora was observed in the increase of inoculation opportunistic enterobacteria in patients of the first group - 43.2%; the second group - 20.0%, and the third group - 28.5%. In 54.0% of patients with the transferred acute intestinal infection and 21.4% for the third group of Staphylococcus aureus was detected. In patients of the second group Staphylococcus aureus was not found.

Conclusions. Intestinal microflora of this patients is characterized by a decrease in the number of lactobacilli, bifidobacteria and E.coli with normal enzymatic activity. As part of the intestinal microbiota surveyed increased the number of opportunistic enterobacteria, Candida. The deficit amount of content obligate microflora such as bifidobacteria, lactobacilli and Escherichia coli with normal enzymatic activity was significantly lower (p <0.05) in patients with chronic disease compared with patients after acute intestinal infection

Volume 3, Number 37 (2015)