Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - Diabetes and osteoporotic fracture. Do clinicians take care of the risk?
Tuba Tülay Koca

The number of patients with lifestyle-related diseases is rapidly increasing in worldwide. İn recent studies both type 1 diabetes and type 2 diabetes mellitus (DM) was found  firmly associated with high fracture risk. Although type 1 DM is associated with lower bone density, those with type 2 DM usually have normal/elevated bone density. Yet both types of DM, bone appears to be more fragile in microarchitecture. Not only hyperglisemia, but also oxidative stress induced deposition of  advanced glycosylation endproducts (AGEs) in collagen, reduced serum level of ınsulin like growth factor 1 (IGF-1), hypercalciuria, renal failure, microangiopathy and inflammation are various mechanisms were hold responsible for lower bone qualty in diabetic population. Additionally falls arising from diabetes-related comorbidities are another possible contributing factor for pathologic fracture in DM. Here we present 13 years-old boy history of type 1 DM with right humerus posttraumatic fracture 1 months ago. Better knowledge on how diabetes and its treatments influence bone tissue will  achieve the effective prevention of high fracture risk in both type 1 and type 2 DM patients.

Volume 3, Number 37 (2015)