Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - Role of Fas-dependent apoptosis in the pathogenesis of ovarian tumors
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Akmaral Kassimova

       In order to understand the pathogenesis of ovarian neoplasms is necessary to study the role of bioactive substances in the mechanisms of regulation "biological behaviour" of the tumor, namely its growth, invasion to surrounding tissues and metastasis. In recent years, researchers has been attracted to study the mechanisms of apoptosis which is programmed and controlled by death of cell with characterized morphological and biochemical features.

       Apoptosis is an extremely important mechanism for maintaining the homeostasis of multicellular organism, due to multicellular organisms damaged cells are removed, which have completed their course of life, as well as "unwanted" cells without damaging the cellular microenvironment. In recent years, it became well known, that one of the key molecules which trigger apoptosis in a cell is the Fas-receptor. Moreover, Fas is expressed in almost all tissue types, this receptor is also expressed on many tumors, including ovarian cancer.

       Similarly, well-functioning Fas-system maintains homeostasis of the organism. Loss of functional activity of the Fas-system induces hyperplasia and lymph proliferation.

Volume 1, Number 31 (2014)