Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - –°irculating tumour cells: molecular properties and anti-cancer treatment monitoring
[PDF]            [Full text/HTML]           
Abay Baigenzhin, Galiya Shaimardanova, Nadezhda Popova, Bakhit Zhussipova, Gulziya Ismailova

Existence of circulating tumor cells (CTCs) in blood of cancer patients, testifies about a dissemination of cancer cells to the peripheral blood stream, on the earliest stages of cancer development and very often testifies to an adverse clinical current, especially it is connected with formation of metastases. Besides, these cells can represent the minimum residual disease and quantitative monitoring of CTCs level in time of anti-cancer treatment provides researchers with valuable information. For today the role of epithelial-to-mesenchymal transit (EMT) and mesenchymal-to-epithelial transit (MET) in formation of various subpopulations CTCs, in expansion of cancer aggressive properties. In this article we want to prove the purpose and problems of our scientific research - the cytological molecular analysis of circulating tumour cells have isolated by the size dependent ISET technology (Isolation by size of epithelial tumor cells). To study the cyto-morphological and immunological characteristic, to identify targeted therapy markers and the metastatic response predictors to anti-cancer treatment on viable circulating cancer cells by the RT-PCR method (real-time polymerase chained action). To study of clinical profit from quantitative, immunological and molecular monitoring of CTCs, for elimination minimum residual disease, by application of individual targeted therapy, on the basis cytological molecular analysis of CTCs.

Volume 4, Number 30 (2013)