Ethnicity and the risk of ventricular arrhythmias due to stable ischemic heart disease

Этническая принадлежность и риск желудочковых аритмий при стабильной ишемической болезни сердца
Yelena Rib 1, Gulnar Zhussupova 1, Zinaida Yugai 2
More Detail
1 Department of Internal Medicine, «Astana Medical University», Astana, Kazakhstan
2 Department of Cardiology, «1st City Hospital», Astana, Kazakhstan
J CLIN MED KAZ, Volume 1, Issue 43, pp. 24-29. https://doi.org/10.23950/1812-2892-JCMK-00370
OPEN ACCESS 3388 Views 2328 Downloads
Download Full Text (PDF)

ABSTRACT

Objective: determination of the of life-threatening ventricular arrhythmias risk in native nationality patients with stable ischemic heart disease.
Methods. The cohort study included 216 patients with stable ischemic heart disease with left ventricular ejection fraction not less than 40%. All participants initially underwent anthropometric measurements, laboratory routine tests, 6-minute walking test, ECG, 24-hours ECG monitoring, echocardiography. After 3, 6 and 12 months, participants were invited to repeat 24-hours ECG
monitoring procedure for life-threatening ventricular arrhythmias episodes detection.
Results. Participants cohort included 130 native nationality persons (Kazakhs) and 86 Caucasian patients. Characteristics of the sample: 181 men (84%), the average age of 62 [57; 66], the average follow-up period - 12,7 ± 1,2 months. Increased relative risk of ventricular arrhythmias in Kazakh patients was revealed: high grading ventricular premature beats RR 1.98 (95% CI 1,02-3,84), P = 0.010); non-sustained ventricular tachycardia RR 2.80 (95% CI 1,07-8,97), P <0.001). Signifcant independent influence on life-threatening ventricular arrhythmias development in patients Kazakh nationality had anemia, obesity, diabetes and limitation in 6-minute walking test performing.
Conclusion. Arrhythmic events in native nationality patients with stable ischemic heart disease without severe left ventricle systolic dysfunction are different from those of Caucasians, that should be considered when predicting the individual risk of arrhythmic events and sudden cardiac death in native nationality patients.

CITATION

Rib Y, Zhussupova G, Yugai Z. Ethnicity and the risk of ventricular arrhythmias due to stable ischemic heart disease. Journal of Clinical Medicine of Kazakhstan. 2017;1(43):24-9. https://doi.org/10.23950/1812-2892-JCMK-00370

REFERENCES

  • Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC) Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). European heart journal. 2015; 29;36(41):2793-2867.
  • Vnezapnaya serdechnaya smert (Sudden cardiac death), Bokeriya L.A., Revishvili A.Sh., Neminuschiy N.M. GEOTAR-Media. Moskva. 2013; 120.
  • Tester D.J., Michael J. Ackerman. Genetics of Cardiac Arrhythmias In: Braunwald’s Heart Disease. 10th edition. Braunwald E, editor. Elsevier Saunders. Philadelphia. 2015; 625.
  • Chen J, Xie X, Zhu J, Tao Q, Wang X. Single-nucleotide polymorphisms in SCN5A gene in Chinese Han population and their correlation with cardiac arrhythmias. Genetics in Medicine. 2004; 1;6(3):159.
  • Sauekenova L.N., Bermagambetova G.N., Mukieva A.B. i dr., Zdorove naseleniya Respubliki Kazahstan i deyatelnost organizatsiy zdravoohraneniya v 2013 godu (Health of the population of the Republic of Kazakhstan and the activities of health organizations in 2013), Statisticheskiy sbornik. Astana, 2014;17-77. 
  • Akilzhanova A.R., Nurkina Zh.M., Bekbosyinova M.S.. Vnezapnaya serdechnaya smert: rol geneticheskih faktorov (Sudden cardiac death: the role of genetic factors), Nauka i zdravoohranenie. 2012; 3:10-13.
  • Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal-Cardiovascular Imaging. 2015; 18;16(3):233-71.
  • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories. Statement AT: Guidelines for the SixMinute Walking-Test. Am J Respir Crit Care Med. 2002;166:111-7.
  • Ardashev A.V., Baevskiy R.M., Balyikova L.A. i dr. Natsionalnyie rossiyskie rekomendatsii po primeneniyu metodiki holterovskogo monitorirovaniya v klinicheskoy praktike (National Russian recommendations on the use of Holter monitoring in clinical practice), Rossiyskiy kardiologicheskiy zhurnal. 2014; 2(106):45.
  • Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death) developed in collaboration with the European Heart Rhythm Association and the .... Europace. 2006; 1;8(9):746-837.
  • Katz D, Baptista J, Azen SP, Pike MC. Obtaining confidence intervals for the risk ratio in cohort studies. Biometrics. 1978; 1:469- 474.
  • Chislennost naseleniya Respubliki Kazahstan po otdelnyim etnosam na nachalo 2015 goda (Population of the Republic of Kazakhstan for selected ethnic groups at the beginning of 2015), Komitet statistiki Ministerstva Ekonomiki Respubliki Kazahstan. Astana, 2015;11.
  • Baimbetov A.K., Bekbosyinova M.S. Registr fibrillyatsii predserdiy v Kazahstane. Pervyie rezultatyi (The register of atrial fibrillation in Kazakhstan. First results), Zdorove Kazahstana. 2013; 21:3.
  • Zhakupova A.S., Ibrasheva D.E., Nurkina Zh.M. i dr. Izuchenie geneticheskih markerov vnezapnoy serdechnoy smerti (The study of genetic markers of sudden cardiac death), Materialyi VIII Mezhdunarodnoy nauchno-prakticheskoy konferentsii «Ekologiya. Radiatsiya. Zdorove». Semey, 2012; 223.
  • Akilzhanova A, Guelly C, Nuralinov O, Nurkina Z, Nazhat D, Smagulov S, Tursunbekov A, Alzhanova A, Rashbayeva G, Abdrakhmanov A, Dosmagambet S. RYR2 sequencing reveals novel missense mutations in a Kazakh idiopathic ventricular tachycardia study cohort. PloS one. 2014; 30;9(6):e101059.
  • Haybullin T.N. Etnicheskie i gendernyie osobennosti rasprostranennosti osnovnyih patogeneticheskih faktorov u bolnyih ishemicheskim insultom v Vostochnom Kazahstane (Ethnic and gender characteristics of the prevalence of major pathogenetic factors in patients with ischemic stroke in East Kazakhstan), Vestnik Novgorodskogo gosudarstvennogo universiteta. 2012; 67:77-82.
  • Sotsialnyiy zakaz «Uslugi po formirovaniyu u naseleniya navyikov zdorovogo pitaniya i bezopasnosti pischevyih produktov» (Services to build the population’s skills of healthy eating and food safety), Zaklyuchitelnyiy otchet. - Almatyi. – P. 98.
  • Kocyigit D., Gürses К.М. Iron deficiency and its treatment in heart failure: indications and effect on prognosis. E-Journal of Cardiology Practice. 2016;14:30.