Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - Ebstein-Barr Virus in Systemic Lupus Erythematosus
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Yaroslav Tolstiak

     The aim. We sought to explore the relative frequencies of Ebstein-Barr (EBV) in adult patients with SLE and their correlation with disease activity and autoantibody.      

      Methods: 56 adult patients satisfying the 1997 American College of Rheumatology (ACR) Classification Criteria for SLE and 31 healthy controls were included in this case-control study. All patients were subjected to complete clinical and laboratory evaluation to determine the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) and the British Isles Lupus Assessment Group index (BILAG). Sera from both groups were analyzed for Ebstein-Barr nucleus antigen immunoglobulin G (EBNA IgG), immunoglobulin M virus capsid antigen EBV (IgM VCA EBV) and IgG VCA EBV antibodies against EBV. Qualitative real time polymerase chain reaction (PCR) for diagnosis of virus presense in blood, saliva and pharyngeal scrape was performed for 35 SLE patients.

       Results: 83.8% SLE patients were positive for IgG anti-EBNA,  63,6% IgG anti-VCA  EBV; 68,7% SLE patients were positive for IgM anti-VCA EBV antibodies. EBV DNA were detected by PCR for blood (39,1%), saliva (25%) and pharyngeal scrape (75%) of SLE patients. Correlation of Ebstein-Barr antibodies and autoantibodies in patients with SLE presentation Anti-EBNA   positive correlation with аutoantibody, except anti-Sm (р>0,05). A statistically significant lower SLEDAI was found in IgG anti-VCA EBV positive patients. Patients with SLE had higher frequencies of anti-EBV compared to healthy controls.

        Conclusions: Correlation of Ebstein-Barr antibodies and autoantibodies in patients with SLE for relation of them with development and flares of SLE.

Volume 1, Number 31 (2014)