Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - Genetic predisposition for the development of complications in patients after coronary artery stenting
Dana Taizhanova, Akerke Kalimbetova, Aliya Toleuova, Rosa Bodaubay, Olga Visternichan, Aigul Kurmanova


In the review the authors analyzed the literature data on the state of knowledge of the problems of genetic polymorphisms CYP2C19 gene response to clopidogrel in patients with acute coronary syndrome. Despite on the technological advances and the widespread use of coronary stenting, restenosis at the site of angioplasty remains the main factor limiting its long-term effectiveness. We made the literature review of the state of the study of the genetic polymorphism of the CYP2C19 gene for a response to clopidogrel in patients with acute coronary syndrome and percutaneous coronary intervention. To achieve this goal, a systematic search and subsequent analysis of publications and online resources were carried out. All publications are indexed in the PubMed, Medline, e-Library, CoogleScholar.

Key words: coronary heart disease, percutaneous coronary angioplasty, stenting, restenosis, clopidogrel, CYP2C19, acute coronary syndrome, gene polymorphism


Corresponding author: Akerke Kalimbetova, Master of Medicine, 1 year  PhD doctoral student, Karaganda Medical University. Address: 40 Gogol Street, Karaganda, Republic of Kazakhstan. Tel: +77053269379, E-mail:



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Volume 4, Number 54 (2019)