Онлайн (Онлайн)ISSN 2313-1519
Баспалық (Печатный) ISSN 1812-2892
Тұжырымдама (Резюме) - Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer
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Hayriye Şahinli, Sema Türker

ABSTRACT

Objective: The prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index has been studied in many cancer types. Our aim is to show the prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index in resected gastric cancer patients. In addition, to determine which parameter is a better predictor of survival.

Material and methods: The study included 95 patients resected gastric cancer between 2014-2018. Receiver operating curve analysis was used to determine neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index cut-off values. Systemic immune-inflammatory index was evaluated as neutrophil × platelet/lymphocyte. Long rank and cox regression analysis were used.

Results: The median age was 62 (22-84) years. The median overall survival was 33 months. 49 (51.6%) patients were in stage 3 and 46 (48.4 %) patients were in stage 1-2. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index values, tumor depth, stage of metastatic lymph node and tumor-node-metastasis stage were poor prognostic factors for overall survival and disease-free survival. When multivariant cox regression analysis was performed, only platelet-lymphocyte ratio was found to be independent prognostic factor (p = 0.037 for overall survival, p = 0.024 for overall survival).

Conclusion: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index were found to be poor prognostic factors in predicting both overall survival and disease-free survival before treatment in patients who undergo curative resection for gastric cancer. As a result of multivariant analysis, only high platelet-lymphocyte ratio was determined as an independent poor prognostic factor for both overall survival and disease-free survival.

Keywords: gastric cancer, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, prognosis

Corresponding author: Hayriye Şahinli, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Medical Oncology, Ankara, Turkey. ORCİD No: 0000-0002-1561-9346. Tel.: 05536934969, E-mail: dr.hayriye@hotmail.com

 

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Көлем (Объем) 4, Сан (Число) 54 (2019)