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Abstract - Relationship between lactate level and length of hospital stay in patients with a COPD exacerbation
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Seda Beyhan Sagmen, Tugba Naziroglu

ABSTRACT

Objective: To investigate the effect of lactate levels on length of hospital stay in patients with chronic obstructive pulmonary disease exacerbation.

Material and methods: Patients who were hospitalized for chronic obstructive pulmonary disease exacerbation between October 2017 and December 2018 were evaluated. Those who had pneumonia or any other additional disease that might affect the lactate level during hospitalization were excluded from the study. The arterial blood gas parameters and lactate levels measured at the time of hospitalization were examined. The patients were divided into two groups according to the length of stay: longer than seven days and shorter than seven days. The relationship of lactate levels with the length of hospital stay and requiring non-invasive mechanical ventilation during hospitalization was investigated.

Results: A total of 101 patients, 28 females (27.72%) and 73 males (72.28%), participated in the study. The mean age of the patients was 68±9 years. Fifty-seven (56.44%) patients were hospitalized for 7 days or less and 44 patients (43.56%) were hospitalized for more than 7 days. The mean length of hospital stay was 7.37 ± 2.24 days. An examination of the relationship between lactate and length of hospital stay revealed a significant correlation (p<0.001; r=0.791). When the patients were divided into two groups according to their length of hospital stay, lactate levels were found to be higher in patients who were hospitalized for longer than seven days (2.74±0.74) compared with patients who were hospitalized for seven days or less (1.50±0.58) (p<0.001). The body mass index of patients hospitalized for longer than seven days was found to be lower than in the patients hospitalized for seven days or less (p<0.001). The lactate levels of the patients requiring non-invasive mechanical ventilation were found to be higher (2.29±0.91) than the other patients (1.70±0.76) (p=0.001). A determinative cut-off point was examined for the lactate level in hospitalizations of patients. When the lactate value was taken as 1.95, 90.91% sensitivity and 84.21% specificity were obtained.

Conclusion: Lactate levels may become important in clinical practice to predict the duration of hospitalization because it can be measured quickly and easily.

Key words: lactate, chronic obstructive pulmonary disease, length of hospital stay, non-invasive mechanical ventilation

Corresponding Author: Seda Beyhan Sagmen, Department of Pulmonary Medicine, Kartal Dr. Lutfi Kirdar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. Tel.: +905054912596. E-mail: sedabeyhansagmen@gmail.com

 

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Volume 3, Number 57 (2020)