Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - Prediabetes is associated with restrictive pattern of lung disease in otherwise asymptomatic adults: a cross-sectional study.
Riyaz Ahmad Lone, Ishtiyaq Ahmad Sofi, Musharaf Bashir


Background: Very few studies have been conducted to study the effects of prediabetes on lung functions. Evidence suggests that prediabetes causes mechanical changes in the periphery of lungs which may have adverse affects on the lung functions.

Material and methods: In this observational cross sectional study, 800 apparently healthy adult subjects were selected who underwent spirometry, fasting plasma glucose analysis and 2-h oral glucose tolerance test. Spirometric indices such as percent predicted values of forced vital capacity, forced expiratory volume in 1 second, and forced vital capacity/forced expiratory volume in 1 second were considered. Based on fasting plasma glucose and 2 hr oral glucose tolerance test the subjects were further divided into two groups, i.e. subjects with normal glucose levels and those with prediabetics.

Results: It was observed that 400 (50%) subjects had normal glucose levels, 400 (50%) had prediabetes. Furthermore it was observed that as compared to the control group, forced vital capacity (% pred.) and forced expiratory volume in 1 second (% pred.) were significantly lower but forced vital capacity/forced expiratory volume in 1 second (% pred.) was significantly higher in prediabetes group.

Conclusion: Based on the results of spirometry it may be concluded that restrictive lung pattern (low lung volume) may be in prediabetes itself before the development of type 2 diabetes mellitus.

Key words: prediabetes, restrictive lung diseasesforced vital capacityforced expiratory volume in 1 second, low lung volume


Corresponding Author: Musharaf Bashir, MD, Demonstrator, Department of Physiology, GMC & SMHS hospital, Srinagar, Jammu and Kashmir, India. Tel.:: +917042272380. E-mail:




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Volume 2, Number 56 (2020)