Online ISSN 2313-1519
Print    ISSN 1812-2892
Abstract - The contribution of hematological parameters to prediction of the phase in stage 2 and stage 3 colon cancers
Erkan Karacan, Eyüp Murat Yılmaz, Buse Yıldız, Ahmet Ender Demirkiran



Purpose: Colorectal cancers are a significant cause of cancer-related deaths around the world. In the preoperative staging of colon cancers, radiological images and various blood tests are used. However, it is both difficult and expensive to apply radiological examinations. In our study, we aimed at predicting the stage of colon cancers by preoperatively viewing the hematological parameters, which are simple, cheap and easy to apply. 

Material and methods: The patients, who had been operated due to colon cancer by a single surgeon in the General Surgery Clinic between January 2015 and January 2020, were divided into two groups as stage 2 and stage 3 according to the tumor-nodule-metastases classification. In these groups, preoperative mean platelet volume, carcinoembryonic antigen, platelet/lymphocyte count ratio and neutrophil/lymphocyte count ratios were checked and evaluated in terms of staging and significance according to postoperative pathology results. According to the tumor-nodule-metastases classification, Stage 1-4 patients, emergency cases, patients with an inflammatory disease and rectal cancer were excluded from the study.   

Results: In the study, 38 of 59 patients who had been operated between January 2015 and January 2020 were found to be at stage 2 (group 1), and 21 patients at stage 3 (group 2). While no significant difference was found between carcinoembryonic antigen and neutrophil/lymphocyte levels between group 1 and group 2, a proportional increase was observed between the increase in platelet/lymphocyte ratio and staging (p=0.041). Mean platelet volume was seen to be proportional to stage progression (p=0.03).  

Conclusion: We think that platelet/lymphocyte ratio and mean platelet volume levels can easily be applied as a cheap and simple test in the prediction of the preoperative stage in stage 2-3 colon cancers.

Key words: colon cancer, neutrophil lymphocyte ratio, platelet lymphocyte ratio, mean platelet volume


Corresponding Author: Erkan Karacan, Department of General Surgery, Aydın State Hospital, Aydin, Turkey. Tel.: +905075657221, E-mail:




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Volume 3, Number 57 (2020)