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Abstract - Association of chronic pancreatitis with risk of diabetes mellitus development
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Yeldos Omirzak, Aliya Toleuova, Kairat Beibitov

ABSTRACT

Introduction: Pancreatogenic diabetes mellitus affects the life quality and it is an independent risk factor for mortality at chronic pancreatitis. In practice, pancreatogenic diabetes mellitus is rarely diagnosed, and patients are incorrectly diagnosed with diabetes mellitus type 1 or type 2.

Objective: To determine the association of chronic pancreatitis with risk of diabetes mellitus developing.

Material and methods: Case-control study design, retrospective studies. The study was conducted on the base of the Municipal hospital №1 of Karaganda. Case histories of 23 patients, their outpatient records and discharges from hospital were studied. The patients were divided into 2 groups during the study: group 1 – the patients with chronic pancreatitis; group 2 – the patients with chronic pancreatitis and diabetes mellitus type 2.

Results and discussion: The study found that the number of patients under 60 years of age with chronic pancreatitis and diabetes mellitus are 4 times higher than the number of patients over 60 years of age. An increase in blood sugar among patients with chronic pancreatitis was associated with an exacerbation of the underlying disease. Predictors of diabetes mellitus in patients with chronic pancreatitis were female gender (OR=1,179) and high glucose level (OR=0,667). High body mass index did not affect an increase in glucose levels in patients with chronic pancreatitis.

Key words: diabetes mellitus, chronic pancreatitis, glucose

Corresponding author: Aliya Toleuova, No1 Department of Internal Diseases, Karaganda Medical University. Address: 40, Gogol Street, 100008, Karaganda city, Republic of Kazakhstan. Tel.: 87771346548. E-mail: A.Toleuova@kgmu.kz

 

References

1.   Tishkovskij S.V., Nikonova L.V., Doroshkevich I.P. Sovremennye podhody k lecheniju pankreatogennogo saharnogo diabeta (Modern approaches to the treatment of pancreatogenic diabetes mellitus) [in Russian]. Zhurnal Grodnenskogo gosudarstvennogo medicinskogo universiteta. 2015; 1:14-18.

2.   L.A. Rujatkina, D.S. Rujatkin. Pankreatogennyj saharnyj diabet/saharnyj diabet tipa 3S (Pancreatogenic diabetes mellitus / type 3C diabetes mellitus) [in Russian]. Saharnyj diabet. 2018; 4:28-35.

3.   M. V. Lobanova. Saharnyj diabet na fone pankreatita (Diabetes mellitus on the background of pancreatitis) [in Russian]. Sluchaj iz praktiki. 2017; 3:123-130.

Volume 4, Number 58 (2020)