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Abstract - Impact of work productivity on quality of life and disease activity in ankylosing spondylitis
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Betül Sargın


Objective: We aimed to evaluate work productivity on the quality of life and disease activity in ankylosing spondylitis.

Material and methods: One hundred ankylosing spondylitis patients were included in the study. Disease activity was assessed by Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), quality of life was assessed by Ankylosing Spondylitis Quality of Life questionnaire, work productivity was assessed by work productivity and activity impairment questionnaire.

Results: Absenteeism, presenteeism, work productivity loss and activity impairment scores were positively correlated with BASDAI. We found correlation between absenteeism, presenteeism, work productivty loss, activity impairment scores and poor quality of life.

Conclusion: As a result of our study, work productivity should be considered in clinical practice. Assessment of work productivity in routine clinical practice can contribute to a better understanding of problems in patients' behavior to treatment.

Key words: ankylosing spondylitis, work productivity, quality of life, disease activity

Corresponding author: Betül Sargin. E-mail: betul.cakir@yahoo.com/ betulsargin83@hotmail.com;

ORCID: https://orcid.org/0000-0002-9463-8413



1. Moreno M, Gratacós J, Torrente-Segarra V, Sanmarti R, Morlà R, Pontes C, Llop M, Juanola X; REMINEA study Group. Withdrawal of infliximab therapy in ankylosing spondylitis in persistent clinical remission, results from the REMINEA study. Arthritis Res Ther. 2019; 2:88.

2. Ward MM, Deodhar A, Gensler LS, Dubreuil M, Yu D, Khan MA, et al. 2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. Arthritis Care Res (Hoboken). 2019; 71:1285-99.

3. Moon KH, Kim YT. Medical Treatment of Ankylosing Spondylitis. Hip & Pelvis. 2014; 26:129.

4. Braun J, Pincus T. Mortality, course of disease and prognosis of patients with ankylosing spondylitis. Clin Exp Rheumatol. 2002; 20:16-22.

5. Andresen EM, Meyers AL. Health-related quality of life outcomes measures. Arch Phys Med Rehabil. 2000; 81:30-45. https://doi.org/10.1053/apmr.2000.20621

6. Laas K, Roine R, Räsänen P, Sintonen H, Leirisalo-Repo M. Health-related quality of life in patients with common rheumatic diseases referred to a university clinic. Rheumatol Int. 2009; 29:267-73. https://doi.org/10.1007/s00296-008-0673-x

7. Awada S, Ajrouche R, Shoker M, Al-Hajje A, Rachidi S, Zein S,et al. Rheumatoid Arthritis in the Lebanese Adults: Impact on Health-Related Quality of Life. J Epidemiol Glob Health. 2019; 9:281-7.

8. Law L, Beckman Rehnman J, Deminger A, Klingberg E, Jacobsson LTH, Forsblad-d'Elia H. Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex. Arthritis Res Ther. 2018; 20:284. https://doi.org/10.1186/s13075-018-1784-8

9. Kawalec P, Malinowski K. Disease activity, quality of life and indirect costs of reduced productivity at work, generated by Polish patients with ankylosing spondylitis. Reumatologia. 2015; 53:301-8. https://doi.org/10.5114/reum.2015.57634

10. Kruntorádová K, Klimeš J, Šedová L, Štolfa J, Doležal T, Petříková A. Work Productivity and Costs Related to Patients with Ankylosing Spondylitis, Rheumatoid Arthritis, and Psoriasis. Value Health Reg Issues. 2014; 4:100-6. https://doi.org/10.1016/j.vhri.2014.07.008

11. Garris C, Oglesby A, Sulcs E, Lee M. Impact of systemic lupus erythematosus on burden of illness and work productivity in the United States. Lupus. 2013; 22:1077-86.

12. De Croon EM, Sluiter JK, Nijssen TF, Dijkmans BA, Lankhorst GJ, Frings-Dresen MH. Predictive factors of work disability in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2004; 63:1362-7. https://doi.org/10.1136/ard.2003.020115

13. van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27:361-8.

14. Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994; 21:2286-91.

15. Graham JE, Rouse M, Twiss J, McKenna SP, Vidalis AA. Greek adaptation and validation of the Ankylosing Spondylitis Quality of Life (ASQoL) measure. Hippokratia. 2015; 19:119-24.

16. Reilly MC, Zbrozek AS, Dukes EM. The validty and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993; 4:353-65. https://doi.org/10.2165/00019053-199304050-00006

17. de HM, Ramonda R, Lorenzin M, Frallonardo P, Punzi L, Ortolan A, et al.Work productivity is associated with disease activity and functional ability in Italian patients with early axial spondyloarthritis: an observational study from the SPACE cohort. Arthritis Research& Therapy. 2016; 18:265. https://doi.org/10.1186/s13075-016-1162-3

18. Boonen A, Boone C, Albert A, Mielants H. Understanding limitations in at-work productivity in patients with active ankylosing spondylitis: the role of work-related contextual factors. J Rheumatol. 2015; 42:93-100. https://doi.org/10.3899/jrheum.131287


Volume 5, Number 59 (2020)