ABO incompatible transplantation

Трансплантация при АВО несовместимости
Venera Altynova 1, Nazym Nigmatullina 1, Saltanat Rakhimzhanova 1, Nagima Mustapaeva 1, Samat Isakov 1
More Detail
1 Kidney Center, National Research Center for Maternal and Child Health, Astana, Kazakhstan
J CLIN MED KAZ, Volume 2, Issue 44, pp. 10-14. https://doi.org/10.23950/1812-2892-JCMK-00360
OPEN ACCESS 3542 Views 2687 Downloads
Download Full Text (PDF)

ABSTRACT

At present, the problem of the lack of donor organs for transplantation remains. The kidney transplantation from incompatibile donors exists with great caution and distrust. But it could significantly shorten the waiting time for the recipient of the donor organ. Incompatibility of the donor and recipient in the ABO system for decades was considered an absolute contraindication to organ transplantation due to the inevitable development of hyperactive rejection. Against the backdrop of a global body deficiency from cadaver donors, the development of lifelong donation is an alternative resource. According to the centers of transplantation in Japan, 45% of organ transplants are transplants with incompatibility according to the ABO system (nAVO). Successful overcoming of this barrier can help to expand the number of donors and, consequently, donor bodies. In addition, the introduction of ABO-incompatible organs into the practice of transplantation can shorten the waiting period.
Keywords: ABO-compatibility, kidney, transplantation, anti-AB antibodies

CITATION

Altynova V, Nigmatullina N, Rakhimzhanova S, Mustapaeva N, Isakov S. ABO incompatible transplantation. Journal of Clinical Medicine of Kazakhstan. 2017;2(44):10-4. https://doi.org/10.23950/1812-2892-JCMK-00360

REFERENCES

  • Mineeva M.V. Gruppyi krovi cheloveka. Osnovyi immunogematologii. (Human blood groups. Fundamentals of immunohematology.) [in Rassian]. SPb. 2005.
  • Starzl T.E., Marchioro T.L., Holmes et al. Renal homografts in patients with major donor-recipient blood group incompatibilities. Surgery. 1964; 55 (2):195–200.
  • Shimmura H, Tanabe K, Ishikawa N, et al. Role of anti-A/B antibody titers in results of ABO-incompatible kidney transplantation. Transplantation. 2000; 70:1331–1335.
  • Rydberg L. ABO-incompatibility in solid organ transplantation. Transfus. Med. 2001;11:325–342.
  • Montgomery RA, Simpkins CE, Segev DL. New options for patients with donor incompatibilities. Transplantation. 2006;82:164– 165.
  • Tsirulnikova IE, Shevchenko OP ABO-incompatible liver transplantation in children: analysis of the world experience. Bulletin of transplantology and artificial organs.( ABO-incompatible liver transplantation in children: analysis of the world experience. Bulletin of transplantology and artificial organs.) [in Rassian]. 2012;4:115-123.
  • Jrg Beimler, Martin Zeier ABO-incompatible transplantation—a safe way to perform renal transplantation? NDT. 2007; 22.
  • Alexandre GPJ, Squifflet JP, De Bryere M, et al. Present experience in a series of 26 ABO-incompatible living donor allografts. Transplant Proc. 1987;19:4538–4542.
  • Takahashi K, Takahara S, et al. Excellent long-term outcome of ABO-incompatible living donor kidney transplantation in Japan. Am J Transplant. 2004;4:1089–1096.
  • Ishida H, Koyama I, Sawada T, et al. Anti-AB titer changes in patients with ABO-incompatibility after living related kidney transplantations: survey of 101 cases to determine whether splenectomies are necessary for successful transplantation. Transplantation. 2000;70:681–685.
  • Saito K, Nakagawa Y, Suwa M, et al. Pinpoint targeted immunosuppression: anti-CD20/MMF desensitization with anti-CD25 in successful ABO-incompatible kidney transplantation without splenectomy. Xenotransplantation. 2006;13:111–117.
  • Takahashi KA. New concept of accomodation in ABO-incompatible kidney transplantation. Clin Transplant. 2005;19(Suppl 14):76–85.
  • Sonnenday C, Warren DS, Cooper M, et al. Plasmapheresis, CMV hyperimmune globulin and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy. Am J Transplant. 2004; 4:1315–1322.
  • Tyden G, Kumlien G, Genberg H, et al. ABO-incompatible kidney transplantations without splenectomy, using antigen-specific immunoadsorption and rituximab. Am J Transplant. 2005; :145–148.
  • Tyden G, Kumlien G, Genberg H, et al. The Stockholm experience with ABO-incompatible kidney transplantations without splenectomy. Xenotransplantation. 2006;13:105–107.
  • Donauer J, Wilpert J, Geyer M, et al. ABO-incompatible kidney transplantations using antigen-specific immunoadsorption and rituximab: a single center experience. Xenotransplantation. 2006;13:108–110.
  • Norden G, Briggs D, Cockwell P, et al. ABO-incompatible live donor renal transplantation using blood group A/B carbohydrate antigen immunoadsorption and anti-CD20 antibody treatment. Xenotransplantation. 2006;13:148–153.
  • Takahashi KA. New concept of accomodation in ABO-incompatible kidney transplantation. Clin Transplant. 2005; 19(Suppl 14):76–85.
  • Shimmura H, Tanabe K, Ishikawa N, et al. Role of anti-A/B antibody titers in results of ABO-incompatible kidney transplantation. Transplantation. 2000;70:1331–1335
  • Segev DL, Simpkins CE, Warren DS, et al. ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment. Am J Transplant. 2005; 5:2570–2575.
  • Ikegami T., Taketomi A., Soejima Y. et al. Rituximab,IVIG, and plasma exchange without graft local infusion treatment: a new protocol in ABO incompatible living donor liver transplantation. Transplantation. 2009;88 (3):303–307.
  • Kim B.W., Park Y.K., Kim Y.B. et al. Effects and problems of adult ABO-incompatible living donor liver transplantation using protocol of plasma exchange, intraarterial infusion therapy, and anti-CD20 monoclonalantibody without splenectomy: case reports of initial experiences and results in Korea. Transplant Proc. 2008;40 (10):3772–3777.
  • Montgomery RA, Simpkins CE, Segev DL. New options for patients with donor incompatibilities. Transplantation. 2006; 82:164–165.
  • Segev DL, Simpkins CE, Warren DS, et al. ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment. Am J Transplant. 2005;5:2570–2575.
  • Rydberg L. ABO-incompatibility in solid organ transplantation. Transfus. Med. 2001;11:325–342.
  • V.A. Goryaynov, M.M. Kaabak, N.N. Babenko, L.A. Shishlo, M.M. Morozova, A.A. Allotransplantatsiya AVO-nesovmestimyih pochek u detey (Allotransplantation of ABO-incompatible kidneys in children) [in Rassian]. 2012.
  • Masaki Muramatsu et al. World journal of transplantation. 2014; 4(1):18-29.