Antimitochindrial and antinuclear antibodies in primary biliary cholangitis

Антимитохондриальные и антинуклеарные антитела при первичном билиарном холангите
Dana Saipiyeva 1 * , Manarbek Askarov 2, Turlybek Tuganbekov 1, Kulsara Rustemova 1, Vladimir Grigorevsky 1, Gulmira Dossatayeva 3, Nina Tostanovskaya 3
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1 No2 Surgical Diseases Department, Astana Medical University, Nur-Sultan city, Republic of Kazakhstan
2 Cellular Technologies and Transplantation Center, National Scientific Medical Center, Nur-Sultan city, Republic of Kazakhstan
3 Therapy and Cellular Technologies Department, National Scientific Medical Center, Nur-Sultan city, Republic of Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 2, Issue 52, pp. 16-22. https://doi.org/10.23950/1812-2892-JCMK-00681
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ABSTRACT

In this work we reviewed the key antimitochondrial and antinuclear antibodies in primary biliary cholangitis – an autoimmune cholestatic disorder with destruction of intralobular biliary ductules. Since the discovery of antibodies to PDC-E2 component of cholangiocyte mitochondrial membrane, more than 60 antimitochindrial and antinuclear antibodies against various cellular components of cholangiocytes have been described to date, which have primary diagnostic and clinical value in identifying the disease progression and prognosis.
Keywords: cholestasis, PDC-E2, antinuclear antibodies, cholangiocytes, autoimmune hepatic disorder

CITATION

Saipiyeva D, Askarov M, Tuganbekov T, Rustemova K, Grigorevsky V, Dossatayeva G, et al. Antimitochindrial and antinuclear antibodies in primary biliary cholangitis. Journal of Clinical Medicine of Kazakhstan. 2019;2(52):16-22. https://doi.org/10.23950/1812-2892-JCMK-00681

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