Association between serum 25-hydroxyvitamin D concentration and severity of seasonal allergic rhinitis in Karaganda region (Kazakhstan)

Marina Izmailovich 1 * , Meruert Gazaliyeva 2, Natalya Glushkova 3, Yuliya Semenova 4, Saniya Burankulova 5, Saltanat Shaydarova 6, Maral Bayazitova 7, Irina Kuznetsova 8
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1 Department of Internal Diseases, Karaganda Medical University, Karaganda, Kazakhstan
2 Clinical Work, Astana Medical University, Astana, Kazakhstan
3 Department of Epidemiology, Biostatistics and Evidence Based Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan
4 School of Medicine, Nazarbayev University, Astana, Kazakhstan
5 Polyclinic No 3 of Karaganda, Karaganda, Kazakhstan
6 Polyclinic No 4 of Karaganda, Karaganda, Kazakhstan
7 Polyclinic No 5 of Karaganda, Karaganda, Kazakhstan
8 Polyclinic No 1 of Karaganda, Karaganda, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 6, pp. 46-50. https://doi.org/10.23950/jcmk/12686
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ABSTRACT

Background: Vitamin D deficiency (VDD) is the one of the major public health problem affecting approximately one billion people all over the world. In recent years, the relationship of allergic diseases with a low concentration of vitamin D has been studied worldwide. An association has been found between small count of serum vitamin D and the development of immune disorders. Patients with allergic disorders and, in particular, with respiratory allergy are susceptible for VDD.
Objective: The study was aimed to assess the levels of serum 25-hydroxyvitamin D (25(OH)D) and their associations with the severity of seasonal allergic rhinitis in the Karaganda region (Kazakhstan).
Material and methods: This cross-sectional study included 416 patients with seasonal allergic rhinitis aged 18-65 years (mean age 39±8 years), 267 of whom were females. VDD was defined as serum concentrations of 25(OH)D below 20 ng/ml.
Results: The median concentration of 25(OH)D in blood serum was below the reference threshold (20 ng/ml) and amounted to 16.1 ng/ml. 75% of patients with seasonal allergic rhinitis had VDD and this was common in all age categories. VDD was more prevalent in female patients (82.8%) as compared with the male patients (61.1%) (p<0,01). Of interest is the fact that low serum 25(OH)D concentration correlated with the severity of symptoms (r =-0.94 and r =-0.67).
Conclusion: According to our study, the significant part of patients with allergic rhinitis residing in Karaganda region (Kazakhstan) had deficient status of 25(OH)D and this correlated with the severity of symptoms.
Keywords: adults, vitamin D deficiency, Karaganda region, Kazakhstan

CITATION

Izmailovich M, Gazaliyeva M, Glushkova N, Semenova Y, Burankulova S, Shaydarova S, et al. Association between serum 25-hydroxyvitamin D concentration and severity of seasonal allergic rhinitis in Karaganda region (Kazakhstan). J CLIN MED KAZ. 2022;19(6):46-50. https://doi.org/10.23950/jcmk/12686

REFERENCES

  • Thakkar B, Katarkar A, Modh D, Jain A, Shah P, Joshi K. Deficiency of vitamin D in allergic rhinitis: A possible factor in multifactorial disease. Clin Rhinol. 2014;7:112-6. https://doi.org/10.5005/jp-journals-10013-1209
  • Mailyan EA, Reznichenko NA, Maylyan DE. Ekstraskeletnyye effekty vitamina D: rol' v patogeneze alergicheskikh zabolevaniy (Extraskeletal effects of vitamin D: role in the pathogenesis of allergic diseases) [in Russian]. Nauchnyye vedomosti Belgorodskogo Gosudarstvennogo Universiteta Seriya: Meditsina Farmatsiya.. 2017;37 5(254):22-32.
  • Dimitrov V, Salehi-Tabar R, An BS, White JH. Non-classical mechanisms of transcriptional regulation by the vitamin D receptor: Insights into calcium homeostasis, immune system regulation and cancer chemoprevention. J Steroid Biochem Mol Biol. 2014;144 PART A:74-80. https://doi.org/10.1016/j.jsbmb.2013.07.012
  • Szymczak I, Pawliczak R. The Active Metabolite of Vitamin D3 as a Potential Immunomodulator. Scand J Immunol. 2016;83:83-91. https://doi.org/10.1111/sji.12403
  • Makarova SG, Namazova-Baranova LS. Vitamins in Prevention and Treatment of Allergic Diseases in Children. Pediatr Pharmacol. 2015;12:562. https://doi.org/10.15690/pf.v12i5.1459
  • Yawn J, Lawrence LA, Carroll WW, Mulligan JK. Vitamin D for the treatment of respiratory diseases: Is it the end or just the beginning? J Steroid Biochem Mol Biol. 2015;148:326-37. https://doi.org/10.1016/j.jsbmb.2015.01.017
  • Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, et al. 25-Hydroxvitamin D 3 Promotes the Long-Term Effect of Specific Immunotherapy in a Murine Allergy Model. J Immunol. 2014;193:1017-23. https://doi.org/10.4049/jimmunol.1301656
  • Barragan M, Good M, Kolls JK. Regulation of dendritic cell function by vitamin D. Nutrients. 2015;7:8127-51. https://doi.org/10.3390/nu7095383
  • Kamen DL, Tangpricha V. Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity. J Mol Med. 2010;88:441-50. https://doi.org/10.1007/s00109-010-0590-9
  • Sikorska-Szaflik H, Sozańska B. The role of vitamin D in respiratory allergies prevention. Why the effect is so difficult to disentangle? Nutrients. 2020;12:1-9. https://doi.org/10.3390/nu12061801
  • Gromova O, Doschanova A, Lokshin V, Tuletova A, Grebennikova G, Daniyarova L, et al. Vitamin D deficiency in Kazakhstan: Cross-Sectional study. J Steroid Biochem Mol Biol. 2020;199:105565. https://doi.org/10.1016/j.jsbmb.2019.105565
  • Pigarova EA, Rozhinskaya LA, Belaya ZHE, Dzeranova LK, Karonova TL, Ilyin AV, et al. Klinicheskiye rekomendatsii Rossiyskoy assotsiatsii endokrinologov po diagnostike, lecheniyu i profilaktike defitsita vitamina D u vzroslykh (Clinical guidelines of the Russian Association of Endocrinologists for the diagnosis, treatment and prevention of vitamin D deficiency in adults) [in Russian]. Problemy endokrinologii. 2016;62:60-84. https://doi.org/10.14341/probl201662460-84
  • Arshi S, Ghalehbaghi B, Kamrava S-K, Aminlou M. Vitamin D serum levels in allergic rhinitis: any difference from normal population? Asia Pac Allergy. 2012;2:45. https://doi.org/10.5415/apallergy.2012.2.1.45
  • Bukhari AF, Felemban MJ, Alem H. The Association Between Serum 25-Hydroxyvitamin D Levels and Patients With Allergic Rhinitis. 2020. https://doi.org/10.7759/cureus.9762
  • Bozzetto S, Carraro S, Giordano G, Boner A, Baraldi E. Asthma, allergy and respiratory infections: The vitamin D hypothesis. Allergy Eur J Allergy Clin Immunol. 2012;67:10-7. https://doi.org/10.1111/j.1398-9995.2011.02711.x
  • Jones AP, Tulic MK, Rueter K, Prescott SL. Vitamin D and allergic disease: Sunlight at the end of the tunnel? Nutrients. 2012;4:13-28. https://doi.org/10.3390/nu4010013
  • Kim YH, Kim KW, Kim MJ, Sol IS, Yoon SH, Ahn HS, et al. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2016;27:580-90. https://doi.org/10.1111/pai.12599
  • Osborne NJ, Ukoumunne OC, Wake M, Allen KJ. Prevalence of eczema and food allergy is associated with latitude in Australia. J Allergy Clin Immunol. 2012;129:865-7. https://doi.org/10.1016/j.jaci.2012.01.037
  • Muehleisen B, Gallo RL. Vitamin D in allergic disease: Shedding light on a complex problem. J Allergy Clin Immunol. 2013;131:324-9. https://doi.org/10.1016/j.jaci.2012.12.1562
  • Lu H, Xie R Di, Lin R, Zhang C, Xiao XJ, Li LJ, et al. Vitamin D-deficiency induces eosinophil spontaneous activation. Cell Immunol. 2017;322 October:56-63. https://doi.org/10.1016/j.cellimm.2017.10.003
  • Nair P, Ochkur SI, Protheroe C. Eosinophil Peroxidase in Sputum Represents a Unique Biomarker of Airway Eosinophilia. Allergy. 2013;68:1177-84. https://doi.org/10.1111/all.12206
  • Jerzyńska J, Stelmach W, Rychlik B, Majak P, Podlecka D, Woicka-Kolejwa K, et al. Clinical and immunological effects of Vitamin D supplementation during the pollen season in children with allergic rhinitis. Arch Med Sci. 2018;14:122-31. https://doi.org/10.5114/aoms.2016.61978
  • Jerzynska J, Stelmach W, Rychlik B, Lechańska J, Podlecka D, Stelmach I. The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis. Allergy Asthma Proc. 2016;37:105-14. https://doi.org/10.2500/aap.2016.37.3921