Case Report: Vesicular Toxicodermia Induced by the Scabies Mite Sarcoptes Scabiei

Marina Izmailovich 1 * , Anna Skvortsova 2, Saltanat Mendibay 3, Kanan Tanriverdiev 4, Kerbez Erlanova 1, Nazerke Kemelbekova 1, Anastasia Gorkovets 1
More Detail
1 Department of Internal Diseases, Karaganda Medical University, Karaganda, Kazakhstan
2 Department of Obstetrics, Gynecology and Perinatology, Karaganda Medical University, Karaganda, Kazakhstan
3 School of public health, Karaganda Medical University, Karaganda, Kazakhstan
4 Department of Endoscopy, LLP «Polyclinic 15», Karaganda, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 4, pp. 78-81. https://doi.org/10.23950/jcmk/14960
OPEN ACCESS 220 Views 100 Downloads
Download Full Text (PDF)
Author Contributions: Conceptualization, M.I. and S.M.; methodology, M.I. and A.S.; validation, M.I. and K.T.; formal analysis, M.I., A.S. and K.E.; investigation, K.E., N.K. and A.G.; resources, K.T., K.E., N.K. and A.G.; data curation, M.I., K.E., N.K. and A.G.; writing – original draft preparation, K.E., N.K. and A.G.; writing – review and editing, M.I.; visualization, S.M.; supervision, M.I.; project administration, M.I. All authors have read and agreed to the published version of the manuscript.

ABSTRACT

This article analyzes a clinical case of vesicular toxicodermia caused by infection with the scabies mite Sarcoptes scabiei. The focus is on a female patient who, according to her medical history, noticed the development of intense itching and rashes on her hands and feet after using an antiseptic. Initial treatment provided no relief, and further investigations confirmed the presence of the scabies mite. The article emphasizes the importance of a comprehensive approach to diagnosing and treating such clinical cases, including careful monitoring for allergic reactions to antiseptics and other potential irritants. Special attention is given to the necessity of etiological therapy directly targeting the scabies pathogen, as well as symptomatic treatment to alleviate itching and inflammatory manifestations.
Keywords: Vesicular toxicodermia, scabies mite Sarcoptes scabiei, scabies complication

CITATION

Izmailovich M, Skvortsova A, Mendibay S, Tanriverdiev K, Erlanova K, Kemelbekova N, et al. Case Report: Vesicular Toxicodermia Induced by the Scabies Mite Sarcoptes Scabiei. J CLIN MED KAZ. 2024;21(4):78-81. https://doi.org/10.23950/jcmk/14960

REFERENCES

  • Kubanova AA, ed. Dermatovenereology. Moscow: DEKS-Press; 2010. (Clinical Guidelines / Russian Society of Dermatovenereologists).
  • Butov YS, Potekaev NN, et al. Dermatovenereology: A Guide for Physicians. Moscow: GEOTAR-Media; 2017.
  • Ministry of Health of the Republic of Kazakhstan. Clinical Protocols – Scabies (B86); 2019.
  • Clinical Guidelines of the Russian Federation. Toxicodermia; 2013-2017.
  • Arora P, Rudnicka L, Sar-Pomian M, et al. Scabies: A comprehensive review and current perspectives. Dermatology Therapy. 2020; 33(4): e13746. https://doi.org/10.1111/dth.13746.
  • Laha R. Sarcoptic mange infestation in pigs: an overview. Journal of Parasitic Diseases. 2015; 39(4): 596-603. https://doi.org/10.1007/s12639-014-0419-5.
  • Arlian LG, Morgan MS. A review of Sarcoptes scabiei: past, present and future. Parasites & Vectors. 2017; 10(1): 297. https://doi.org/10.1186/s13071-017-2234-1.
  • Walton SF, Oprescu FI. Immunology of scabies and translational outcomes: identifying the missing links. Current Opinion in Infectious Diseases. 2013; 26(2): 116-122. https://doi.org/10.1097/QCO.0b013e32835eb8a6.
  • Shimose L, Munoz-Price LS. Diagnosis, prevention, and treatment of scabies. Current Opinion in Infectious Diseases. 2013; 15(5): 426-431. https://doi.org/10.1007/s11908-013-0354-0.
  • Mounsey EK, McCarthy SJ, Walton FS. Scratching the itch: new tools to advance understanding of scabies. Trends in Parasitology. 2013; 29(1): 35-42. https://doi.org/10.1016/j.pt.2012.09.006.
  • Dispenza MC. Classification of hypersensitivity reactions. Allergy and Asthma Proceedings. 2019; 40(6): 470-473. https://doi.org/10.2500/aap.2019.40.4274.
  • Næsborg-Nielsen C, Wilkinson V, Mejia-Pacheco N, Carver S. Evidence underscoring immunological and clinical pathological changes associated with Sarcoptes scabiei infection: synthesis and meta-analysis. BMC Infectious Diseases. 2022; 22(1): 658. https://doi.org/10.1186/s12879-022-07635-5.
  • Abd El-Aal AA, Hassan MA, Gawdat HI, Ali MA, Barakat M. Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies. International Journal of Immunopathology and Pharmacology. 2016; 29(2): 188-194. https://doi.org/10.1177/0394632015627464.
  • Walton SF, Pizzutto S, Slender A, Viberg L, Holt D, Hales BJ, et al. Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies. Clinical Vaccine Immunology. 2010; 17(9): 1428-1438. https://doi.org/10.1128/CVI.00195-10.
  • Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H. Basophil recruitment and activation in inflammatory skin diseases. Allergy. 2011; 66(8): 1107-1113. https://doi.org/10.1111/j.1398-9995.2011.02570.x.
  • Schroeder JT. Basophils: emerging roles in the pathogenesis of allergic disease. Immunological Reviews. 2011; 242(1): 144-160. https://doi.org/10.1111/j.1600-065X.2011.01023.x.
  • Cote NM, Jaworski DC, Wasala NB, Morgan MS, Arlian LG. Identification and expression of macrophage migration inhibitory factor in Sarcoptes scabiei. Experimental Parasitology. 2013; 135(1): 175-181. https://doi.org/10.1016/j.exppara.2013.06.012.
  • Luo DQ, Huang MX, Liu JH, Tang W, Zhao YK, Sarkar R. Bullous scabies. American Journal of Tropical Medicine and Hygiene. 2016; 95(3): 689-693. https://doi.org/10.4269/ajtmh.16-0273.
  • Elwood H, Berry RS, Gardner JM, Shalin SC. Superficial fibrin thrombi and other findings: a review of the histopathology of human scabetic infections. Journal of Cutaneous Pathology. 2015; 42(5): 346-352. https://doi.org/10.1111/cup.12482.
  • Saint Petersburg Dermatological Readings XI Scientific and Practical Conference of Dermatovenereologists and Cosmetologists. October 26-28, 2017. Collection of Abstracts. ISBN 978-5-9908987-8-3.