Clinical and economic efficiency of multi-matrix mesalazine in ulcerative colitis treatment in the healthcare system of the Republic of Kazakhstan

Клинико-экономическая эффективность мультиматричного месалазина в терапии неспецифического язвенного колита в условиях здравоохранения Республики Казахстан
Alima Almadiyeva 1, Venera Almatova 2, Timur Balabayev 3, Marat Sultanov 4, Karlygash Absattarova 1 *
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1 Public Healthcare Department, Kazakhstani Agency on Healthcare Technologies Assessment, Nur-Sultan city, Republic of Kazakhstan
2 Department of Radiodiagnosis and Radiotherapy, Astana Medical University, Nur-Sultan city, Republic of Kazakhstan city, Republic of Kazakhstan
3 Public Healthcare Department, Kazakhstan Association of Healthcare Technologies Assessment, Evidencebased Medicine and Pharmacoeconomics Research “KazSPOR”, Nur-Sultan city, Republic of Kazakhstan city, Republic of Kazakhstan
4 Public Healthcare Department, Nazarbayev University, Nur-Sultan city, Republic of Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 2, Issue 52, pp. 30-36. https://doi.org/10.23950/1812-2892-JCMK-00680
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ABSTRACT

Aim: Clinical and economic evaluation of multi-matrix mesalazine 1200 mg compared with prolonged-release mesalazine at a dose of 500mg for the treatment of patients aged 18 years and older with the diagnosis of ulcerative colitis in the phase of exacerbation and remission.
Material and methods: In accordance with the PICOS tool all published literature sources were identified in the electronic resources PubMed/Medline, DARE, Cochrane Central Register of Controlled Trials; the analysis included 5 studies with levels of evidence A and B. Calculations were performed in STATA and Microsoft Excel 10.0
Results and discussion: According to the results of clinical and economic analysis, the strategy of using multi-matrix mesalazine is dominant in comparison with prolonged-release mesalazine as a first-line therapy and contributes to the increment of efficiency and leads to the minimization of costs to achieve a QALY unit per patient. Patients receiving multi-matrix mesalazine have a longer duration of remission and less likelihood of re-exacerbations.
Conclusion: The use of multi-matrix mesalazine in comparison with prolonged-release mesalazine is an economically feasible alternative in the conditions of health care of the Republic of Kazakhstan – more effective and less financially costly, leading to potential budget savings.
Keywords: multi-matrix mesalazine, non-specific ulcerative colitis, Crohn's disease, efficacy, QALY

CITATION

Almadiyeva A, Almatova V, Balabayev T, Sultanov M, Absattarova K. Clinical and economic efficiency of multi-matrix mesalazine in ulcerative colitis treatment in the healthcare system of the Republic of Kazakhstan. Journal of Clinical Medicine of Kazakhstan. 2019;2(52):30-6. https://doi.org/10.23950/1812-2892-JCMK-00680

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