Effects of regular administration of red wine on testicular profile and body weight in adult male experimental mode

Ubi Essien Isaac 1 * , Kebe Edet Obeten 1, Anozeng Oyono Igiri 2
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1 Department of Human Anatomy and Forensic Science, Faculty of Basic Medical Sciences, Cross River University of Technology, Calabar, Nigeria
2 Department of Human Anatomy, College of Medical Sciences, University of Calabar, Calabar, Nigeria
* Corresponding Author
J CLIN MED KAZ, Volume 18, Issue 4, pp. 75-80. https://doi.org/10.23950/jcmk/11050
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ABSTRACT

Background: The present study determined whether or not the regular intake of red wine causes any significant changes in testicular and body weight parameters, given the simmering controversy over the effect of alcoholic beverages on health system.
Methods: Ten male albino Wistar rats –experimental model with average body weight of 140 g were divided into two groups, A and B, (n=5 each). Group A received distilled water being the control while group B was administered a single daily dose of 5 ml/kg body weight of red wine (Carlo Rossi) for 21 days. An electronic weighing scale (G&G® Neuss, Germany) was used to take record of the initial and final body weights. The animals were anesthetized with isoflurane on the 22nd day to enable collection of the testes which were also weighed and thereafter fixed in 10% neutral formalin for routine histological studies. The analysis of variance (ANOVA) was used with the ‘R’ software to analyze the statistical data, while P<0.05 was taken as the significant value.
Results: The micro-anatomical investigation revealed enhanced perfusion of the tissue and normal morphology of the seminiferous tubules with constituent spermatogenic cells at different stages of maturation. The biometric assessment of the organ (testis) weight showed no significant difference; whereas there was a statistically significant increase in the final body weight of the treated-experimental model when compared with the control.
Conclusion: The findings indicate that the intake of red wine at the investigated amount may maintain the integrity of the primary reproductive structure and lead to body weight gain in males.
Keywords: Red wine, testis, maintenance, body weight, increase

CITATION

Isaac UE, Obeten KE, Igiri AO. Effects of regular administration of red wine on testicular profile and body weight in adult male experimental mode. J CLIN MED KAZ. 2021;18(4):75-80. https://doi.org/10.23950/jcmk/11050

REFERENCES

  • Snopec L, Mlcek J, Sochorova L, Baron M, Hlavacova I, Jurikova T, et al. Contribution of red wine consumption to human health protection. Molecules. 2018; 23(7): 1684. DOI: 10.3390/molecules23071684.
  • Macrae R, Robinson RK, Saddler MJ. Wine: In Encyclopaedia of Food Science and Technology 2nd ed. London: Harcourt Brace; 1993. p. 73-92.
  • Sharma AK, Singh PN, Sawant SD. Evaluation of fermentation efficiency of yeast strains and their effect on quality of young wines. Indian J Microbiol. 2012; 53(2): 495-9. doi: 10.1007/s12088-011-0226-y
  • Khoo HE, Azlan A, Tang ST, Lim SM. Anthocyanins; colored pigments as food, pharmaceutical ingredients and the potential health benefits. Food Nutri Res. 2017; 61: 1361779. Doi:10.1080/16546628.2017.1361779
  • Turturica M, Qancea AM, Rapeanu G. Anthocyanins naturally occurring fruit pigments with functional properties. Food Technol. 2015; 39(1) 9-24.
  • Renaud S, Gueguen R. The French paradox and wine drinking. Norvatis Found Symp. 1998; 216: 208-17. doi: 10.1002/9780470515549.ch13.
  • O’keefe JH, Bybee KA, Lavie CJ. Alcohol and cardiovascular health: The razor sharp double-edged sword. J Am Coll Cardiol. 2007; 50(11):1009-14. Doi: 10.1016/j.jacc.2007.04.089.
  • Freiberg MS, Samet JH. Alcohol and coronary heart disease: The answer awaits a randomized control trail. Circulation. 2005; 112(10):1379-81. Doi: 10.1161/CIRCULATIONAHA.105.568030.
  • Hansel B, Thomas F, Pannier B, Bean K, Kentush A, Chapman MJ, et al. Relationship between alcohol intake, health and social status and cardiovascular risk factors in the Urban Paris- lle-de-France Cohort; Is the cardioprotective action of alcohol a myth? Eur J Clin Nutr. 2010; 64:561-8. https://doi.org/10.1038/ejcn.2010.61
  • Cavallini G, Straniero S, Donati A, Bergamini E. Resveratrol requires red wine polyphenols for optimum antioxidant activity. J Nutr Health Aging. 2016; 20:540-5. DOI: 10.1007/812603-150611-z.
  • Fiore M, Laviola G, Aloe L, Fausto V, Mancineh R, Coccanti M. Early exposure of ethanol but not red wine at the same alcohol concentration induces behavioral and brain neotrophin alterations in young and adult mice. Neurotoxicology. 2009; 30(1): 59-71. https://doi.org/10.1016/j.neuro.2008.11.009.
  • Di-Castelnuovo A, Rotondo S, Lacoviello L, Donati MB., De Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation. 2002; 105(24): 2836-44. Doi: 10.1161/01.cir.0000018653.19696.01.
  • Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolamen C. Alcohol and coronary heart disease: A meta-analysis. Addiction. 2000; 95(10): 1505-23. Doi: 10.1046/j.1360-0443.2000.951015056.x.
  • Maclure M. Demonstration of deductive meta-analysis: Ethanol intake and risk of myocardiac infarction. Epidemiol Rev. 1993; 15(2): 328-51. Doi: 10.1093/oxfordjournals.epirev.a036124.
  • Lim SS, Von T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, et al. A comparative risk assessment of burden of diseases and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: A systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859):2224-60. Doi: 10.1016/SO140-6736(12)61766-8.
  • Walorczyk S, Drodynski D, Gnusowski B. Multiresidue determination of 160 pesticides in wines employing mixed-mode dispersive-solid phase extraction and gas chromatography-tandem mass spectrometry. Talanta. 2011; 85(4):1856-1870. DOI: 10.1016/j.talanta.2011.07.029.
  • Tariba B. Metals in wine impact on wine quality and health outcomes. Biol Trace Elem Res. 2011; 144(1-3): 143-56. DOI: 10.1007/s12011-011-9052-7.
  • Magrone T, Jirillo E. Potential application of dietary polyphenols from red wine to attaining healthy ageing. Curr Top Med Chem. 2011; 11(14): 1780-1796. doi: 102174/156802611796235116
  • Rodrigo R, Miranda A, Vergara L. Modulation of endogenous antioxidant system by wine polyphenols in human disease. Clin Chim Acta. 2011; 412(5-6): 410-24. Doi: 10.1016/j.cca.2010.11.034.
  • Oczkowski M, Srednicka-Tober D, Stachon M, Kolota A, Wolinska-Witort E, Malik A, et al. The effect of red wine consumption on hormonal reproductive parameters and total antioxidant status in young adult male rats. Food Funct. 2014; 5(9): 2096-105. https://doi.org/10.1039/C4O00108G
  • Golan R, Shelef I, Shemesh E, Henkin Y, Schwarzfuchs D, Gepner Y, et al. Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes: A 2-year randomized controlled trial. Public Health Nutri. 2017; 20:549-555. DOI: 10.1017/S1368980016002597
  • Gepner Y, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Shelef I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: A 2 year randomized, controlled trial. Ann Intern Med. 2015; 163: 569-79. Doi: 10.7326/M14-1650
  • Downer MK, Betoroia ML, Mukamal KJ, Rimm EB, Stampfer MJ. Change in alcohol intake in relation to weight change in a cohort of United States men with 24 years of follow-up. Obesity. 2017; 25:1988-1996. DOI: 10.1002/oby.21979
  • Maclnnis RJ, Hodge AM, Dixon HG, Peeters A, Johnson LE, English DR, et al. Predictors of increased body weight and weight circumference for middle-aged adults. Public Health Nutri. 2014; 17:1087-1097. DOI: 10.1017/S1368980013001031
  • Dumesnil C, Dauchet L, Ruidavets JB, Bingham A, Arveiler D, Ferrieres J, et al. Alcohol consumption patterns and body weight. Ann Nutr Metab. 2013; 62:91-7. Doi: 10.1159/000342839
  • Drobinis EZ, Johnson M. The question of sperm DNA fragmentation testing in the male infertility work-up: A response to Professor Lewis’ commentary. Reprod Biomed Online. 2015; 31:138-39. doi: 10.1016/j.rbmo.2015.05.004
  • Whitfield M, Pollet-Villard X, Levy R, Drevet JR, Saez F. Post-testicular sperm maturation, infertility and hypercholesterolemia. Asian J Androl. 2015; 17(5):742-8. Doi: 10.4103/1008-682X.155536.
  • Katib A. Mechanisms linking obesity to male infertility. Cent European J Urol. 2015; 68(1):79-85. Doi: 10.5173/ceju.2015.01.435.
  • Esmaeilzadeh S, Andarieh MG, Ghadimi R, Delavar MA. Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome. Glob J Health Sci. 2014; 7(2):101-6. Doi: 10.5539/gjhs.v7n2p101
  • Ranawat P, Khanduja KL, Pathak CM. Resveratrol-an ingredient of red wine abrogates the reproductive capacity in male mice. Andrologia. 2014; 46(6): 650-8 DOI: 10.1111/and.12132.
  • Pavlidou E, Mantzorou M, Fasoulas A, Tryfonos C, Petridis D, Giaginis C. Wine: An aspiring agent in promoting longevity and preventing chronic diseases. Diseases. 2018; 6(3):73. DOI: 10.3390/diseases6030073
  • Sayon-Orea C, Bes-Rastrollo M, Nunez-Corboda JM, Basterra-Gortari FJ, Beunza JJ, Martinez-Gonzalez MA. Type of alcoholic beverage and incidence of overweight/obesity in a Mediterranean cohort: The SUN project. Nutr. 2011; 27:802-8. DOI: 10.1016/j.nut.2010.08.023
  • French MT, Norton EC, Fang H. Alcohol consumption and body weight. Health Econ. 2010; 19:814-32. DOI: 10.1002/hec.1521
  • Traversy G, Chaput J. Alcohol consumption and obesity: An update. Curr Obes Rep. 2015; 4(1):122-130. DOI: 10.1007/s13679-014-0129-4.
  • Monteiro R., Soares R., Guerreiro S., Pestana D., Calhau C., Azevedo I. Red wine increases adipose tissue aromatase expression and regulates body weight and adipocytes size. J Nutr Biochem. 2009; 25(6): 699-705. Doi: 10.1016/j.nut.2009.01.001.
  • Bargallo MV, Grau AA, Fernandez-Larrea, JD, Anguiano GP, Segerra MC, Rovira MJ, et al. Moderate red wine consumption partially prevents body weight gain in rats fed a hyperlipidic diet. J Nutr Biochem. 2006; 17(2):139-42. https://doi.org/10.1016/j.nutbio.2005.06.005.
  • Fernandes I, Perez-Gregorio R, Soares S, Mateus N, de Freitas V. Wine flavonoids in health and disease prevention. Molecules. 2007; 22: 292. DOI: 103390/molecules22020292.
  • Cains S, Blomeley C, Burdakov D. Agrp neuron activity is required for alcohol-induced overeating. Nat Commun. 2017; 8:14014. https://doi.org/10.1038/ncomms14014.
  • Isaac UE, Akpuaka FC, Ndukwe GU. The effect of intake of palm wine on body weight and testicular microarchitecture in adult wistar rats. J Exp Clin Anat. 2017; 16(1):12-7. Available: https://www.jecajournal.org/text.asp?2017/16/1/12/212635. [Accessed 2020 Dec. 8].
  • Buemann B, Toubro S, Astrup A. The effect of wine or beer versus a carbonated soft drink, served at a meal, on ad libitum energy intake. Int J. Obes Relat Metab Disord. 2002; 26(10): 1367-72. Doi: 10.1038/sj.ijo.0802069.