Etiological structure from sputum of patients with progressive respiratory infections
Микробный спектр мокроты больных с прогрессирующими респираторными заболеваниями
Nelya Bissenova 1, Aigerim Yergaliyeva 1
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1 National Scientific Medical Research Center, Astana, Kazakhstan
J CLIN MED KAZ, Volume 3, Issue 33, pp. 17-21.
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ABSTRACT
The aim of this study was to analyses etiological structure from sputum of patients with progressive respiratory infections.
Materials and methods. The sputum of hospitalized patients diagnosed with progressive respiratory infection during 2009-2013 was included to the prospective bacteriological study. Initial seeding material conducted a quantitative method on nutrient medium according to guidelines. The identification of isolates and antibiotic susceptibility testing were performed by microbiological analyzer Microtax, MiniApi and Vitek 2-Compact. The etiological factor was defined at a concentration of 106 and above. The results were subjected to statistical analysis. We determined averages, an averages error (m), Students test, a confidence interval (p). The probability of null hypothesis did not exceed 0.05 (p<0.05).
Results. A total of 838 strains (43 species) were obtained from sputum of patients with progressive respiratory infections during 2009-2013. Streptococcus pneumoniae was determined in 337 (40.2%) strains, Moraxella catarrhalis – 17.0%, Streptococcus viridans – 12.1%, Streptococcus pyogenes – 6.3%, Staphylococcus aureus – 4.4%, Pseudomonas aeruginosa – 2.1% of total isolates.
Conclusions. Streptococcus pneumoniae and Moraxella catarrhalis were the most frequently pathogens (40.2% and 17.0% respectively) from sputum of patients with progressive respiratory infections in our region.
CITATION
Bissenova N, Yergaliyeva A. Etiological structure from sputum of patients with progressive respiratory infections. Journal of Clinical Medicine of Kazakhstan. 2014;3(33):17-21.
REFERENCES
- Дворецкий Л.И. Ключевые вопросы антибактериальной терапии обострений хронической обструктивной болезни легких// Пульмонология. - 2011. - №4. – С.87-96
- Козлов Р.С. Принципы антибактериальной терапии при инфекционном обострении ХОБЛ с позиций доказательной медицины// Пульмонология. Аллергология. Риноларингология. – 2009. - №2. – С.27
- Глобальная стратегия диагностики, лечения и профилактики хронической обструктивной болезни легки. // Пер. с англ. под ред. Чучалина А.Г. Атмосфера. Москва.2003. – 96с.
- Veeramachaneni S.B., Sethi S. Pathogenesis of bacterial exacerbations of COPD// COPD. – 2006. – N.3. – P.109–115
- Авдеев С.Н. Антибактериальная терапия при обострении хронической обструктивной болезни легких// Пульмонология. – 2010. - №2. – С.96-106
- Monso E., Ruiz J., Rosell A. et al. Bacterial infection in chronic obstructive pulmonary diseases: A study of stable and exacerbated outpatients using the protected specimen brush// Am.J.Respir.Crit.Care Med.- 1995. – N.152. – P.1316-1320
- Pela R., Marchesani F., Agostinelli C. et al. Airways microbial flora in COPD patients in stable clinical conditions and during exacerbations: A bronchoscopic investigation// Monaldi Arch. Chest Dis. – 1998. – N.53. – P. 262–267.
- Кречикова О.И., Козлов Р.С., Богданович Т.М., Стецюк О.У., Суворов М.М. Выделение, идентификация и определение чувствительности к антибиотикам Streptococcus pneumoniae. Методические рекомендации для микробиологов. М. - 2000
- Бисенова Н.М., Митус Н.М., Тулеубаева Э.А. и др. Мониторинг бактериального спектра мокроты больных с пневмонией и обострением ХОБЛ// Лабораторная диагностика. – 2011. - №1. – С.56-58