Factors associated with fibro-cavernous tuberculosis

Arailym Abilbayeva 1 * , Anel Tarabayeva 1, Akbope Myrkassymova 2, Amanzhan Abubakirov 3, Ilsiyar Khaertynova 4, Eduard Shuralev 5
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1 Department of General Immunology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
2 Department of Biostatistics and Basics of Scientific Research, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
3 Department of Phthisiopulmonology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
4 Department of Infectious Diseases, Kazan State Medical Academy – a branch of the federal state budgetary educational institution of additional professional education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Health of the Russian Federation, Kazan, Tatarstan, Russian Federation
5 Department of Applied Ecology, Institute of Environmental Sciences, Kazan Federal University, Kazan, Tatarstan, Russian Federation
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 5, pp. 28-33. https://doi.org/10.23950/jcmk/12504
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ABSTRACT

Objective: To identify socio-demographic, clinical and laboratory risk factors associated with fibro-cavernous tuberculosis.
Material and methods: Clinical and laboratory data of 184 patients with pulmonary tuberculosis who were treated at the National Scientific Center for Phthisiopulmonology of the Ministry of Healthcare of the Republic of Kazakhstan were analyzed. Specific antibodies to the lipoglycan of M.tuberculosis (MBT) were evaluated in an immunochromatographic assay. To assess the significance of differences in groups, the Pearson Chi-Square test was used. To determine factors associated with the fibro-cavernous tuberculosis, а multiple binary logistic regression analysis was carried out.
Results: Multivariate logistic regression analysis showed that low BMI (OR=5,719, 95% CI: 2,049–15,965, p=0,001), TB recurrence (OR=3.374, 95% CI: 1,191–9,561, p=0,022), and a negative specific production of antibodies to lipoglycan of M.tuberculosis (MBT) (OR=0,354, 95% CI: 0,126-0,995, p=0,049) were significantly associated with fibro-cavernous tuberculosis.
Conclusion: Weight deficiency, high antibodies levels and TB relapse are factors associated with fibro-cavernous tuberculosis.
Keywords: infiltrative tuberculosis, fibro-cavernous tuberculosis, risk factors, anti-tuberculosis antibodies

CITATION

Abilbayeva A, Tarabayeva A, Myrkassymova A, Abubakirov A, Khaertynova I, Shuralev E. Factors associated with fibro-cavernous tuberculosis. J CLIN MED KAZ. 2022;19(5):28-33. https://doi.org/10.23950/jcmk/12504

REFERENCES

  • WHO. Global tuberculosis report. 2020:13.
  • Pavlunin A.V. Kavernoznyy i fibrozno-kavernoznyy tuberkulez legkikh: sovremennyy vzglyad na patogenez, diagnostiku i lechenie (Cavernous and fibrous-cavernous pulmonary tuberculosis: a modern view on pathogenesis, diagnosis and treatment) [Russian]. SТМ. 2012;1:115-122.
  • Urbanowski M.E., Ordonez A.A., Ruiz-Bedoya C.A., Jain P.S.K., Bishai W.P.R. Cavitary tuberculosis: the gateway of disease transmission. Lancet Infect Dis. 2020;20(6):e117-e118. https://doi.org/10.1016/S1473-3099(20)30148-1
  • Sarathy J.P., Zuccotto F., Hsinpin H., Sandberg L., Via L., Marriner G.A., et al Prediction of Drug Penetration in Tuberculosis Lesions. ACS Infect. Dis.2016;2:552–563. https://doi.org/10.1021/acsinfecdis.6b00051
  • Kim S.H., Shin Y.M., Yoo J.Y., Cho J.Y., Kang H., Lee H., et al Clinical Factors Associated with Cavitary Tuberculosis and Its Treatment Outcomes. Journal of Personalized Medicine. 2021;11:1-10. https://doi.org/10.3390/jpm11111081
  • Rhines A.S. The role of sex differences in the prevalence and transmission of tuberculosis. Tuberculosis. 2013;93(1):104-107. https://doi.org/10.1016/j.tube.2012.10.012
  • Moldobekova E.M. Gendernye osobennosti zabolevaemosti tuberkulezom v g.Bishkek (Gender characteristics of tuberculosis incidence in Bishkek) [Russian]. Ezhemesyachnyy nauchno-prakticheskiy meditsinskiy zhurnal «Meditsina Kyrgyzstana». 2013;4:207-210.
  • Badawi A., Gregg B., Vasileva D. Systematic analysis for the relationship between obesity and tuberculosis. Public health. 2020;186:246-256. https://doi.org/10.1016/j.puhe.2020.06.054
  • Yen Y.-F., Tung F.-I., Ho B.-L., Lai Y.-J. Underweight increases the risk of early death in tuberculosis patients. Br J Nutr.v2017;118:1052–1060. https://doi.org/10.1017/S0007114517003166
  • Rytter M.J.H., Kolte L., Briend A., Friis H. Christensen, V.B. The Immune system in children with malnutrition—A Systematic review. PLoS ONE. 2014;9:E105017. https://doi.org/10.1371/journal.pone.0105017
  • Scrimshaw N.S., San Giovanni J.P. Synergism of nutrition, infection, and immunity: An overview. Am. J. Clin. Nutr.1997;66:464S–477S. https://doi.org/10.1093/ajcn/66.2.464S
  • Abilbayeva А.А., Tarabayeva А.S., Bitanova E.Zh., Erbolat D., Tuyebaeva B.Т., Shuralev E.A. Effektivnost antigenov Mycobacterium tuberculosis v diagnostike tuberkuleza immunokhromatograficheskim ekspress-testom (The effectiveness of Mycobacterium tuberculosis antigens in the diagnosis of tuberculosis by immunochromatographic rapid test) [Russian]. Vestnik KazNMU. 2019;4:289-293.
  • Ashenafi S., Aderaye G., Bekele A., Zewdie M., Aseffa G., Hoang A.T. N., et al Progression of clinical tuberculosis is associated with a Th2 immune response signature in combination with elevated levels of SOCS3. Clin Immunol. 2014;151:84-99. https://doi.org/10.1016/j.clim.2014.01.010
  • Fan L., Xiao H., Mai G., Su B., Ernst J., Hu Zh. Impaired M. tuberculosis Antigen-Specific IFN-γ Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis. PLoS ONE. 2015;10(5):e0127087. https://doi.org/10.1371/journal.pone.0127087
  • Menon J., Hoeppner V. H., Judd A., Power C. A., Bretscher P. A. A hypothesis for the existence of two types of tuberculosis, reflecting two distinct types of immune failure to control the pathogen, based upon prevalence of mycobacterium-specific IgG subclasses. Scand J Immunol. 2018;87(6):e12665. https://doi.org/10.1111/sji.12665
  • Wang L, Cai Y, Cheng Q, Hu Y, Xiao H Imbalance of Th1/Th2 cytokines in patients with pulmonary tuberculosis. Chinese Journal of Tuberculosis and Respiratory. 2002;25(9):535-537.
  • Mazzarella G., Bianco A., Perna F., D’Auria D., Grella E., Moscariello E., Sanduzzi A. T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis. Clin. Exp. Immunol. 2003;132:283–288. https://doi.org/10.1046/j.1365-2249.2003.02121.x
  • Sakamuri R.M., Ryndak M.B., Singh K.K., Laal S. Evolution of Antibodies to Epitopes of PE_PGRS51 in the Spectrum of Active Pulmonary Tuberculosis. J Infect Dis. 2020;221(9):1538–1541. https://doi.org/10.1093/infdis/jiz546
  • Porkulevich N.I., Mordyk A.V., Gurova Ya.V., Martynova G.G. Analiz prichin formirovaniya fibrozno-kavernoznogo tuberkuleza (Analysis of the causes of fibrous-cavernous tuberculosis formation) [Russian]. Tuberkulez i bolezni legkikh. 2015;5:154-155.
  • Chiang C.-Y., Lee J.-J., Chien S.-T., Enarson D.A., Chang Y.-C., Chen Y.-T., et al Glycemic control and radiographic manifestations of tuberculosis in diabetic patients. PLoS ONE. 2014;9:e93397. https://doi.org/10.1371/journal.pone.0093397
  • Nakamura A., Hagiwara E., Hamai J., Taguri M., Terauchi Y. Impact of underlying diabetes and presence of lung cavities on treatment outcomes in patients with pulmonary tuberculosis. Diabet. Med. 2014;31:707–713. https://doi.org/10.1111/dme.12414