Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

Влияние ресвератрола на структурно-функциональное состояние щитовидной железы у больных аутоиммунным тиреоидитом в сочетании со стабильной ишемической болезнью сердца
Natalya Chekalina 1
More Detail
1 Department of Internal Medicine, Ukrainian Medical Stomatological Academy, Poltava, Ukraine
J CLIN MED KAZ, Volume 1, Issue 43, pp. 48-55. https://doi.org/10.23950/1812-2892-JCMK-00443
OPEN ACCESS 4972 Views 2632 Downloads
Download Full Text (PDF)

ABSTRACT

Objective: to study the influence of resveratrol on the structural and functional state of the thyroid gland by levels of thyroid hormones, antibodies and ultrasound data of the thyroid gland in patients with stable coronary heart disease (IHD) in combination with autoimmune thyroiditis (AIT).
Methods: 110 patients took part in the study: 60 patients with IHD: stable angina pectoris, FCII, 30 of whom had concomitant AIT, euthyroid, 20 patients with AIT and 30 healthy volunteers. On the background of standard therapy (β-blockers, statins, aspirin), patients with IHD and IHD in combination with AIT were assigned resveratrol at a dose of 100 mg per day for 2 months. Before and after the course of therapy, patients were diagnosed with free thyroxine (T4 free), thyroid stimulating hormone (TSH) and antibodies to thyroperoxidase (AT-TPO). To all participants were made ultrasound of the thyroid gland with pulse-wave dopplerography.
Results: In patients with IHD and AIT under the influence of resveratrol, the level in the blood of TSH decreased, T4 free increased, AT-TPO did not change signifcantly. The same dynamics of the studied indicators was found in patients with IHD. All patients with AIT had an increase in the values of the arterial thyroid blood flow. The use of resveratrol contributed to a decrease the velocity and index of blood flow resistance in the thyroid arteries, which may be associated with its anti-inflammatory, endothelioprotective, thyroprotective effects. There was no evidence of the effect of resveratrol on normal thyroid blood flow in patients with IHD.
Conclusion: In patients with IHD in combination with AIT, the use of resveratrol improves thyroid functional status and thyroid blood flow parameters, which makes the relevance to use of resveratrol in treatment of AIT and IHD in combination with AIT.
Keywords: resveratrol, autoimmune thyroiditis, ischemic heart disease, thyroid function, blood flow thyroid parameters

CITATION

Chekalina N. Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease. Journal of Clinical Medicine of Kazakhstan. 2017;1(43):48-55. https://doi.org/10.23950/1812-2892-JCMK-00443

REFERENCES

  • Vanderpump MP. The epidemiology of thyroid disease. British Medical Bulletin. 2011;99(1):39-51.
  • Bobyryova LY, Muravlyova OV, Gorodynska OY. Autoimmune Thyroiditis: Clinical Course Features and Principles of Differential Therapy. International journal of endocrinology. 2014;1(57):17-24.
  • Braverman LE, Cooper D. Werner & Ingbar’s the thyroid: a fundamental and clinical text. Lippincott Williams & Wilkins; 2012 Jul 12.
  • Staii A, Mirocha S, Todorova-Koteva K, Glinberg S, Jaume JC. Hashimoto thyroiditis is more frequent than expected when diagnosed by cytology which uncovers a pre-clinical state. Thyroid research. 2010;3(1):11.
  • Brent GA. Environmental exposures and autoimmune thyroid disease. Thyroid. 2010;20(7):755-761.
  • Pearce SH, Brabant G, Duntas LH, Monzani F, Peeters RP, Razvi S, Wemeau JL. 2013 ETA guideline: management of subclinical hypothyroidism. European thyroid journal. 2013;2(4):215-28.
  • Tronko ND. Standards of diagnosis and treatment of endocrine diseases. Textbook» VADEMECUM info DOCTOR Endocrinologist». Kyiv: TOV» GIRA»» Zdorovia Ukrainy. 2005.
  • Duntas LH. Resveratrol and its impact on aging and thyroid function. J Endocrinol Invest. 2011;34(10):788-92.
  • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery. 2006;5(6):493.
  • Bhullar KS, Hubbard BP. Lifespan and healthspan extension by resveratrol. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2015;1852(6):1209-1218.
  • Chekalina NI. Anti-inflammatory effects of resveratrol in stable coronary artery disease and concomitant autoimmune thyroiditis. S’rdechno-s’ dovi Zabolyavaniya/Medical Review-Cardiovascular Diseases. 2016;47(3):3-8.
  • Ge JF, Xu YY, Li N, Zhang Y, Qiu GL, Chu CH, Wang CY, Qin G, Chen FH. Resveratrol improved the spatial learning and memory in subclinical hypothyroidism rat induced by hemi-thyroid electrocauterization. Endocrine journal. 2015;62(10):927- 938.
  • Tang PC, Ng YF, Ho S, Gyda M, Chan SW. Resveratrol and cardiovascular health–promising therapeutic or hopeless illusion?. Pharmacological research. 2014;90:88-115.
  • Chekalina N. Resveratrol reduces the inflammatory activation of endothelum in patients with coronary heart disease combined with autoimmune thyroiditis. J Clin Med Kaz. 2016;3(41):21-26. doi: 10.23950/1812-2892-2016-3-21-26
  • Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, Ferreira JR. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. European heart journal. 2013;34(38):2949-3003.
  • Egorov AM, Osipov AP, Dzantiev BB, Gavrilova EM. Teoriya i praktika immunofermentnogo analiza (Theory and practice of enzyme immunoassay). Moscow. Izdatel’stvo «Vysshaya shkola». 1991; 288 pp.
  • Chaudhary V, Bano S. Thyroid ultrasound. Indian journal of endocrinology and metabolism. 2013;17(2):219.
  • Caruso G, Attard M, Caronia A, Lagalla R. Color Doppler measurement of blood flow in the inferior thyroid artery in patients with autoimmune thyroid diseases. European journal of radiology. 2000;36(1):5-10.
  • Huber G, Staub JJ, Meier C, Mitrache C, Guglielmetti M, Huber P, Braverman LE. Prospective study of the spontaneous course of subclinical hypothyroidism: prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies. The Journal of Clinical Endocrinology & Metabolism. 2002;87(7):3221-3226.
  • Kaidashev I.P. Sistema sirtuinov i vozmozhnosti regulirovaniya eyo sostoyaniya v klinicheskoy praktike (obzor literaturyi) (System of sirtuins and possibilities of regulation of its statein the clinical practice (literature review)). Zhurnal NAMN Ukrai’ny. 2012;18(4):418-429.
  • Giuliani C, Di Santo S, Hysi A, Iezzi M, Bucci I, Napolitano G. Anti-Thyroid Effect of Resveratrol. InHPT Axis Biology, Health Disparities, Non-neoplastic Thyroid Disorders, and Thyroid Immunology (posters) 2016 Apr (pp. SUN-261). Endocrine Society.
  • Falchetti R, Fuggetta MP, Lanzilli G, Tricarico M, Ravagnan G. Effects of resveratrol on human immune cell function. Life sciences. 2001;70(1):81-96.
  • Laupheimer MW, Perry M, Benton S, Malliaras P, Maffulli N. Resveratrol exerts no effect on inflammatory response and delayed onset muscle soreness after a marathon in male athletes.: A randomised, double-blind, placebo-controlled pilot feasibility study. Translational medicine@ UniSa. 2014;10:38-42 
  • Cheserek MJ, Wu G, Li L, Li L, Karangwa E, Shi Y, Le G. Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity. The Journal of nutritional biochemistry. 2016;33:36-44.
  • Wang B, Sun J, Li X, Zhou Q, Bai J, Shi Y, Le G. Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet–induced obesity. Nutrition research. 2013;33(11):971-981.
  • Chekalina N.I. Korrelyatsionnyie svyazi mezhdu pokazatelyami sistemnogo vospaleniya, lipidnogo spektra krovi i tireoidnoy funktsii pri ishemicheskoy bolezni serdtsa v sochetanii s autoimmunnyim tireoiditom (Correlation between the indicators of systemic inflammation, lipid spectrum of blood and thyroid function in coronary heart disease in combination with autoimmune thyroiditis). Vestnik VGMU. 2016;15(5):7-17.
  • Tanigaki K, Sundgren N, Khera A, Vongpatanasin W, Mineo C, Shaul PW. Fcγ receptors and ligands and cardiovascular disease. Circulation research. 2015;116(2):368-384.
  • Mazziotti G, Sorvillo F, Naclerio C, Farzati A, Cioffi M, Perna R, Valentini G, Farzati B, Amato G, Carella C. Type-1 response in peripheral CD4+ and CD8+ T cells from patients with Hashimoto’s thyroiditis. European journal of endocrinology. 2003;148(4):383-388.
  • Manna SK, Mukhopadhyay A, Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-κB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology. 2000;164(12):6509-6519.