Local transport of antibiotics in the treatment of tubular bones chronic osteomyelitis: Literary review
Alexander Rudenko 1 2 * ,
Berik Tuleubaev 1 2 More Detail
1 Department of Surgical Diseases, Karaganda Medical University, Karaganda, Kazakhstan
2 Emergency Traumatology Unit, Professor Kh. Zh. Makazhanov Multidisciplinary Hospital, Karaganda, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 2, pp. 14-20.
https://doi.org/10.23950/jcmk/11995
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ABSTRACT
Local bacterial infection after surgery is a formidable complication in traumatology and orthopedics. Local use of antibiotics as an independent type of therapy and in combination with systemic use of antibiotics can lead to the cure of wound infection. Currently, local transport of antibiotics directly into infection focus is increasingly used, in addition to the local use of antiseptics, which has become a traditional method of purulent wounds treating. This method has undeniable advantages in the treatment of osteomyelitis, since due to the variety of forms of local antibiotic transport available today; it allows effective treatment of intraosseous infection without resorting to daily opening and wound trauma. The purpose of this literature review is to analyze all the available data on the treatment of local bacterial infection after surgery in traumatology and orthopedics, as well as on the most promising methods of treating osteomyelitis today.
CITATION
Rudenko A, Tuleubaev B. Local transport of antibiotics in the treatment of tubular bones chronic osteomyelitis: Literary review. J CLIN MED KAZ. 2022;19(2):14-20.
https://doi.org/10.23950/jcmk/11995
REFERENCES
- Andriole V, Nagel D., Southwickparadigm W. A paradigm for human chronic osteomyelitis. JBoneJointSurgAm. 1973;55(7):1511–1515. https://doi.org/10.2106/00004623-197355070-00019
- Barret L., Atkins B. The clinical presentation of prosthetic joint intection J. Antimicrob Chemother. 2014; 69(1):25-7. https://doi.org/10.1093/jac/dku250
- Bauer TW. Parcvizi J. Kobayashi N. Krebs V. Diagnosis of periprostetic infection. J Bone and Joint Surg. Am. 2006; 88(4):869-882. https://doi.org/10.2106/JBJS.E.01149
- Materials of the consensus conference on periprosthetic infection. Per. from English under. [in Russian] total ed. R.M. Tikhilova. SPb: RNIITO im. R.R. Harmful: 2014. 355p.
- Mikulich EV., current principles of treatmentof chronic osteomyelitis. Journal of New Medical Technologies. 2012; 19(2):180 [in Russian]
- Wininger D.. Fass R. Antimicrobial agents and chemotherapy, Dec. Antimicrob. Agents chemothe. 1996; 40(12):2675–2679. https://doi.org/10.1128/aac.40.12
- Privolnev VV., Zubareva NA., Karakulina EV. Topical therapy of wound infections: antiseptics or antibiotics? [in Russian] 2017; 19(2):131.
- Dombrowski ET., Dunn AW. Treatment of osteomyelitis by debridement and closed wound irrigation-suction. Clin. Orthop. 1966; 43:215–231. https://doi.org/10.1097/00003086-196500430-00020
- Bozhkova SA., Novokshonova AA., Konev VA. Current trends in local antibacterial therapy of periprosthetic infection and osteomyelitis [in Russian]. Traumatology and Orthopedics of Russia. 2015;(3):92-107. https://doi.org/10.21823/2311-2905-2015-0-3-92-107
- van Belt de H, Neut D, Schenk W, van Horn JR, van Der Mei HC, Busscher HJ. Staphylococcus aureus biofilm formation on different gentamicin-loaded polymethylmethacrylate bone cements. Biomaterials. 2001; 22(12):1607–1611. https://doi.org/10.1016/s0142-9612(00)00313-6
- Fleming A. 1919–1920. The action of chemical and physiological antiseptics in a septic wound. Br. J. Surg. 7:99–129. https://doi.org/10.1002/bjs.1800072508
- Jensen NK.,. Johnsrud LW, Nelson MC. The local implantation of sulfanilamide in compound fractures. Surgery. 1939; 6:1–12. https://doi.org/10.5555/uri:pii:S0039606039901571
- Zilberman M., Elsner JJ. Antibiotic-eluting medical devices for various applications. J. Control Release. 2008;130:202–215. https://doi.org/10.1016/j.jconrel.2008.05.020
- Buchholz HW., Engelbrecht H. Uber die Depotwirkung einiger Antibiotica bei Vermischung mit dem Kunstharz Palacos. Chirurg.1970; 41(11):511– 515.
- Klemm K. 1979. Gentamycin-PMMA-Kugeln in der Behandlung abszedierender Knochen- und Weichteilinfektionen. Zentralbl. Chir. 104:934–942.
- Fish DN., Hoffman HM, and DanzigerLH. Antibiotic-impregnated cement use in U.S. hospitals. Am. J. Hosp. Pharm. 1992; 49(10):2469–2474. https://doi.org/10.1093/ajhp/49.10.2469
- Nelson C.L. The current status of material used for depot delivery of drugs. ClinOrthopRelatRes. 2004; (427):72-8. https://doi.org/10.1097/01.blo.0000143741.92384.18
- Prigge EK. The treatment of chronic osteomyelitis by the use of muscle transplant or iliac graft. J Bone Joint Surg Am. 1946; 28:576–593. https://doi.org/10.1001/archsurg.1949.01240030194006
- De Grood DM. Het plomeren van restholten na osteomyelitis met “bone-chips”. Ned Tijdschr Geneeskd. 1947;91.III.32:2192–2196. Dutch
- Hogeman KE. Treatment of infected bone defects with cancellous bone-chip grafts. Acta Chir Scand. 1949; 98(3–6):576–590.
- Buchman J, Blair JE. The surgical management of chronic osteomyelitis by saucerization, primary closure, and antibiotic control; preliminary report on use of aureomycin. J Bone Joint Surg Am. 1951; 33(A:1):107–118. https://doi.org/10.2106/00004623-195133010-00008
- McLaren AC, Miniachi A. In vivo study to determine the efficacy of cancellous bone graft as a delivery vehicle for antibiotics. Proceeding of the 12th Annual Meeting of the Society of Biomaterials; May 28–June 1, 1986; Minneapolis, Minnesota, USA. p. 102
- Gogia JS, Meehan JP, Di Cesare PE, Jamali AA. Local antibiotic therapy in osteomyelitis. Semin Plast Surg. 2009; 23(2):100–107. https://doi.org/10.1055/s-0029-1214162
- Drago L, Romanò D, De Vecchi E, et al. Bioactive glass BAG-S53P4 for the adjunctive treatment of chronic osteomyelitis of the long bones: an in vitro and prospective clinical study. BMC Infect Dis. 2013;13:584. https://doi.org/10.1186/1471-2334-13-584
- Hanssen A.D., Osmon D.R., Patel R. Local antibiotic delivery systems: what are and where are we going? Clin Orthopaed Rel Res 2005; 437:111-4. https://doi.org/10.1097/01.blo.0000175122.50804.ce
- Bozhkova SA., Novokshonova AA., Konev VA. Current trends in local antibacterial therapy of periprosthetic infection and osteomyelitis. Traumatology and Orthopedics of Russia. [in Russian] 2015;(3):92-107. https://doi.org/10.21823/2311-2905-2015-0-3-92-107
- iData Research. US Orthopedic Biomaterials Market – 2013 [webpage on the Internet]. iData Research Inc.; 2013. Available at: http://www.idataresearch.com/us-orthopedic-biomaterials-market-research-report-2013/(accepted 15 August 2021)
- Ostermann PA, Seligson D, Henry SL. Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases. J Bone Joint Surg Br. 1995;77(1):93–97. https://doi.org/10.1302/0301-620X.77B1.7822405
- Buchman J, Blair JE. The surgical management of chronic osteomyelitis by saucerization, primary closure, and antibiotic control; preliminary report on use of aureomycin. J Bone Joint Surg Am. 1951;33(A:1):107–118. https://doi.org/10.2106/00004623-195133010-00008
- Scott DM, Rotschafer JC, Behrens F. Use of vancomycin and tobramycin polymethylmethacrylate impregnated beads in the management of chronic osteomyelitis. Drug Intell Clin Pharm. 1988;22(6):480–483. https://doi.org/10.1177/106002808802200607
- Chisholm BB, Lew D, Sadasivan K. The use of tobramycin-impregnated polymethylmethacrylate beads in the treatment of osteomyelitis of the mandible: report of three cases. J Oral Maxillofac Surg. 1993;51(4):444–449; discussion 449–450. https://doi.org/10.1016/s0278-2391(10)80366-0
- Karr JC. Management in the wound-care center outpatient setting of a diabetic patient with forefoot osteomyelitis using Cerament Bone Void Filler impregnated with vancomycin: off-label use. J Am Podiatr Med Assoc. 2011;101(3):259–264. https://doi.org/10.7547/1010259
- McLaren AC, McLaren SG, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin Orthop Relat Res. 2006;451:25–28. https://doi.org/10.1097/01.blo.0000229321.53040.a1
- Lewis G, Janna S. Estimation of the optimum loading of an antibiotic powder in an acrylic bone cement: gentamicin sulfate in SmartSet HV. Acta Orthop. 2006;77(4):622–627. https://doi.org/10.1080/17453670610012700
- Nandi S.K., Munkeherjee P., Ray S., Kundu B., De D.K., Basu D. Local antibiotic delivery systems for the treatment of osteomyelitis. A review. Materials Science and Engineering. 2009; 29:2478-85. https://doi.org/10.1016/j.msec.2009.07.014
- Lewis G, Brooks JL, Courtney HS, Li Y, Haggard WO. An Approach for determining antibiotic loading for a physician-directed antibiotic-loaded PMMA bone cement formulation. Clin Orthop Relat Res. 2010;468(8):2092–2100. https://doi.org/10.1007/s11999-010-1281-0
- Rutledge B, Huyette D, Day D, Anglen J. Treatment of osteomyelitis with local antibiotics delivered via bioabsorbable polymer. Clin Orthop Relat Res. 2003;411:280–287. https://doi.org/10.1097/01.blo.0000065836.93465.ed
- Liu SJ, Wen-Neng Ueng S, Lin SS, Chan EC. In vivo release of vancomycin from biodegradable beads. J Biomed Mater Res. 2002;63(6):807–813. https://doi.org/10.1002/jbm.10406
- Dacquet V, Varlet A, Tandogan RN, et al. Antibiotic-impregnated plaster of Paris beads. Trials with teicoplanin. Clin Orthop Relat Res. 1992;282:241–249. https://doi.org/10.1097/00003086-199209000-00032
- Gitelis S, Brebach GT. The treatment of chronic osteomyelitis with a biodegradable antibiotic-impregnated implant. J Orthop Surg (Hong Kong). 2002;10(1):53–60. https://doi.org/10.1177/230949900201000110
- Richelsoph KC, Webb ND, Haggard WO. Elution behavior of daptomycin-loaded calcium sulfate pellets: a preliminary study. Clin Orthop Relat Res. 2007;461:68–73. https://doi.org/10.1097/BLO.0b013e3181123889
- Mirzayan R, Panossian V, Avedian R, Forrester DM, Menendez LR. The use of calcium sulfate in the treatment of benign bone lesions. A preliminary report. J Bone Joint Surg Am. 2001;83-A(3):355–358. https://doi.org/10.2106/00004623-200103000-00006
- Kelly CM, Wilkins RM, Gitelis S, Hartjen C, Watson JT, Kim PT. The use of a surgical grade calcium sulfate as a bone graft substitute: result of a multicenter trial. Clin Orthop Relat Res. 2001;382:44–50. https://doi.org/10.1097/00003086-200101000-00008
- Coetzee AS. Regeneration of bone in the presence of calcium sulfate. Arch Otolaryngol. 1980;106(7):405–409. https://doi.org/10.1001/archotol.1980.00790310029007
- Trampuz A, Zimmerli W. Diagnosis and treatment of infections associated with fracture-fixation devices. Injury. 2006; 37(Suppl 2):S59–S66. https://doi.org/10.1016/j.injury.2006.04.010
- McKee MD, Wild LM, Schemitsch EH, Waddell JP. The use of an antibiotic-impregnated, osteoconductive, bioabsorbable bone substitute in the treatment of infected long bone defects: early results of a prospective trial. J Orthop Trauma. 2002;16(9):622–627. https://doi.org/10.1097/00005131-200210000-00002
- Richelsoph KC, Webb ND, Haggard WO. Elution behavior of daptomycin-loaded calcium sulfate pellets: a preliminary study. Clin Orthop Relat Res. 2007;461:68–73. https://doi.org/10.1097/BLO.0b013e3181123889
- Webb ND, McCanless JD, Courtney HS, Bumgardner JD, Haggard WO. Daptomycin eluted from calcium sulfate appears effective against Staphylococcus. Clin Orthop Relat Res. 2008;466(6):1383–1387. https://doi.org/10.1007/s11999-008-0245-0
- Scott DM, Rotschafer JC, Behrens F. Use of vancomycin and tobramycin polymethylmethacrylate impregnated beads in the management of chronic osteomyelitis. DrugIntellClinPharm. 1988;22(6):480–483. https://doi.org/10.1177/106002808802200607
- Mikulich E.V., current principles of treatmentof chronic osteomyelitis. Journal of New Medical Technologies.[In Russian] 2012; 19(2):180.
- Rueger JM. [Bone substitutes. State of the art and: what lies ahead?]. Unfallchirurg. 1996;99(3):228–236. German.
- Joseph TN, Chen AL, Di Cesare PE. Use of antibiotic-impregnated cement in total joint arthroplasty. J Am Acad Orthop Surg. 2003;11(1):38–47. https://doi.org/10.5435/00124635-200301000-00006
- De Grood DM. Het plomeren van restholten na osteomyelitis met “bone-chips”. Ned Tijdschr Geneeskd. 1947;91.III.32:2192–2196. Dutch. https://doi.org/10.2147/ORR.S44747
- Mohanty SP, Kumar MN, Murthy NS. Use of antibiotic-loaded polymethyl methacrylate beads in the management of musculoskeletal sepsis – a retrospective study. J Orthop Surg (Hong Kong). 2003;11(1):73–79. https://doi.org/10.1177/230949900301100115
- McLaren AC. Alternative materials to acrylic bone cement for delivery of depot antibiotics in orthopaedic infections. Clin Orthop Relat Res. 2004;427:101–106. https://doi.org/10.1177/230949900301100115
- Mader JT, Calhoun J, Cobos J. In vitro evaluation of antibiotic diffusion from antibiotic-impregnated biodegradable beads and polymethylmethacrylate beads. Antimicrob Agents Chemother. 1997;41(2):415–418. https://doi.org/10.1128/AAC.41.2.415
- Liu SJ, Wen-Neng Ueng S, Lin SS, Chan EC. In vivo release of vancomycin from biodegradable beads. J Biomed Mater Res. 2002;63(6):807–813. https://doi.org/10.1002/jbm.10406
- Ueng SW, Yuan LJ, Lin SS, et al. In vitro and in vivo analysis of a biodegradable poly(lactide-co-glycolide) copolymer capsule and collagen composite system for antibiotics and bone cells delivery. J Trauma. 2011;70(6):1503–1509. https://doi.org/10.1097/TA.0b013e3181edb873
- Hench LL, Wilson J. Surface-active biomaterials. Science. 1984; 226(4675):630–636. https://doi.org/10.1126/science.6093253
- Thomas DB, Brooks DE, Bice TG, DeJong ES, Lonergan KT, Wenke JC. Tobramycin-impregnated calcium sulfate prevents infection in contaminated wounds. Clin Orthop Relat Res. 2005;441:366–371. https://doi.org/10.1097/01.blo.0000181144.01306.b0
- Maier GS, Roth KE, Andereya S, et al. In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes. Open Orthop J. 2013;7:624–629. https://doi.org/10.2174/1874325001307010624