Metabolomics in search of noninvasive biomarkers for allograft rejection in pediatric kidney transplantation
Vitaliy Sazonov 1 2 3 * ,
Azhar Zhailauova 1,
Sholpan Altynova 3,
Mirgul Bayanova 3,
Gulnur Daniyarova 3,
Aidos Bolatov 4,
Yuriy Pya 3 More Detail
1 Department of Surgery, School of Medicine, Nazarbayev University
2 Nazarbayev University
3 Corporate Fund “University Medical Center”
4 Shenzhen University
* Corresponding Author
J CLIN MED KAZ, In press.
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ABSTRACT
Introduction: Kidney transplantation recognized as the most effective treatment for children with end-stage renal disease (ESRD), offering significant improvements in quality of life and long-term survival. Traditional methods of detecting AR primarily involve invasive biopsy procedures that, while diagnostic, carry significant risks, especially in pediatric patients. Therefore, there is an urgent need for safer, less invasive and more patient-friendly methods to monitor graft health. Metabolomics, the comprehensive analysis of small-molecule metabolites within a biological sample, offers a promising solution
Materials and Methods: This paper is a nonsystematic review. PubMed and Scopus-indexed journals were used to collect papers for the research. Overall, 6 papers were included.
Results: Our findings indicate that specific urinary metabolites can serve as sensitive and specific indicators of AR, offering a safer alternative to biopsies. Metabolomic profiling not only provides real-time insights into graft health but also supports personalized management strategies to enhance patient outcomes. This study contributes to the evolving field of transplant diagnostics, demonstrating how noninvasive methods like metabolomics could revolutionize the monitoring and management of pediatric kidney transplant recipients.
CITATION
Sazonov V, Zhailauova A, Altynova S, Bayanova M, Daniyarova G, Bolatov A, et al. Metabolomics in search of noninvasive biomarkers for allograft rejection in pediatric kidney transplantation. J Clin Med Kaz. 2024.