Modern vision on the problem of urolithiasis in children: Epidemiology, etiopathogenesis, clinical, diagnostics, treatment, metaphylaxis

Assel Sagymbayeva 1 2 *
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1 Department of Pediatric Surgery, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
2 Pediatric Urology Department, Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 18, Issue 6, pp. 9-14. https://doi.org/10.23950/jcmk/11346
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ABSTRACT

According to the study literature, urolithiasis remains one of the most common nosologies among the child population. In connection with the global changes in the health status of the population of our planet, the social significance of urolithiasis has recently acquired new relevance. The mechanism of stone formation is a complex process; stones are formed as a result of urine saturation with oxalates, calcium, uric acid, cystine. Most stones in children are located in the upper urinary tract. In 15%-25% of cases in children, urolithiasis may be asymptomatic. Diagnostics today are not difficult. If urolithiasis is suspected, first, among the instrumental research methods, ultrasound examination of the urinary tract is used, which identifies both X-ray-positive and X-ray-negative stones. Nowadays, not all standards for treating obstructing stones of the upper urinary tract in children of various sizes and localizations, as well as the type of pelvis structure, have been defined. Simultaneously, new trends in treatment may change already existing standards. It should be noted that in the modern world, and ways of metaphylaxis urolithiasis in children studied insufficiently. In the world literature, there is insufficient information on predicting the occurrence of recurrence of urolithiasis and ways to eliminate them. This literature review examines the epidemiology, etiopathogenesis of urolithiasis, diagnosis, existing treatment standards and metaphylaxis. Methods of active tactics of treatment of obstructive stones of the upper urinary tract are analysed in more detail.

CITATION

Sagymbayeva A. Modern vision on the problem of urolithiasis in children: Epidemiology, etiopathogenesis, clinical, diagnostics, treatment, metaphylaxis. J CLIN MED KAZ. 2021;18(6):9-14. https://doi.org/10.23950/jcmk/11346

REFERENCES

  • Romero V, Akpinar H, Assimos DG. Kidney stones: a global picture of prevalence, incidence, and associated risk factors. Rev Urol. 2010;12(2-3): 86-96.
  • Alchinbaev MK, Urolithiasis in Kazakhstan. Analysis of the situation and prospects [in Russian]. Urology and Nephrology of Kazakhstan. 2016; 2; 9-21.
  • Akimoto M, Higashihara E, Kumon H, Masaki Z, Orikasa S. Treatment of Urolithiasis. Germany: Springer-Verlag; 2001. 126 p.
  • Straub M, Gschwend J, Zorn C. Pediatric urolithiasis: the current surgical management. Pediatr Nephrol. 2010;25(7):1239-44. https://doi: 10.1007/s00467-009-1394-4.
  • Sorokin I, Mamoulakis, K. Miyazawa, A. Rodgers, J. Talati, Y. Lotan Epidemiology of stone disease across the world. World J. Urol. 2017. 35 (9):1301-1320. https://doi: 10.1007/s00345-017-2008-6
  • Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, Traxer O, Tiselius HG. Kidney stones. Nat Rev Dis Primers. 2016; 2:16008. https://doi: 10.1038/nrdp.2016.8.
  • Randall A. The origin and growth of renal calculi. Ann Surg. 1937; 105(6):1009-27. https://doi: 10.1097/00000658-193706000-00014.
  • Randall A. Papillary pathology as a precursor of primary renal calculus. Journal of Urology. 1940; 44:580. https://doi.org/10.1016/S0022-5347(17)71305-5
  • Randall A. The etiology of primary renal calculus. International Abstract of Surgery. 1940; 71:209.
  • Stoller ML, Low RK, Shami GS, McCormick VD, Kerschmann RL. High resolution radiography of cadaveric kidneys: unraveling the mystery of Randall's plaque formation. J Urol. 1996;156(4):1263-6. https://doi: 10.1016/s0022-5347(01)65565-4.
  • Khan SR, Canales BK. Unified theory on the pathogenesis of Randall's plaques and plugs. Urolithiasis. 2015 ;43 Suppl 1(01):109-23. https://doi: 10.1007/s00240-014-0705-9.
  • Khan SR, Rodriguez DE, Gower LB, Monga M. Association of Randall plaque with collagen fibers and membrane vesicles. J Urol. 2012 ;187(3):1094-100. doi: 10.1016/j.juro.2011.10.125.
  • Solkh RM, Andryukhin MI, Makarov OV, Fedchenkov VV Improvement of treatment results in patients with ureteral calculi after contact ureterolithotripsy. Research and practice in medicine [in Russian]. 2017; 2:8-12.
  • Seregin AV, Mulabaev NS, Tolordava ER. Modern aspects of the etiopathogenesis of urolithiasis [in Russian]. Medicine. 2012; 4:4-10.
  • Pasupuleti S, Sule N, Manson MD, Jayaraman A. Conversion of Norepinephrine to 3,4-Dihdroxymandelic Acid in Escherichia coli Requires the QseBC Quorum-Sensing System and the FeaR Transcription Factor. J Bacteriol. 2017; 200(1):e00564-17. https://doi: 10.1128/JB.00564-17.
  • Tao Y, Pinzón-Arango PA, Howell AB, Camesano TA. Oral consumption of cranberry juice cocktail inhibits molecular-scale adhesion of clinical uropathogenic Escherichia coli. J Med Food. 2011; 14(7-8):739-45. https://doi: 10.1089/jmf.2010.0154.
  • David G. Thanassi, James B. Bliska, Peter J. Christie, Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function, FEMS Microbiology Reviews. 2012; 36(6):1046–1082. https://doi.org/10.1111/j.1574-6976.2012.00342.x
  • Monico CG, Milliner DS. Genetic determinants of urolithiasis. Nat Rev Nephrol. 2011; 8(3):151-62. https://doi: 10.1038/nrneph.2011.211.
  • Turk C, Neisius A, Petrik A, et al. EAU Guidelines on urolithiasis. European Association of Urology. 2021; 87
  • Maltsev S.V., Mikhailova T.V. Genetic and clinical aspects of nephrolithiasis and nephrocalcinosis in children with hypercalciuria [in Russian]. Pediatrics 2014; 9 (85): 118-25.
  • Filippova T.V. Rudenko V.I. Genetic aspects of primary hyperoxaluria: epidemiology, aetiology, pathogenesis and clinical manifestations [in Russian]. Bulletin of the Russian Society of Urology. 2019; (3): 24-5
  • Svetlichnaya D. V. Litvinova M. M. Molecular genetic panel in the assessment of susceptibility to urolithiasis. [in Russian] Materials of the Congress. XIX Congress of the Russian Society of Urology (September 19-21, Rostov-on-Don) 2019; from. 195
  • Kambadakone AR, Eisner BH, Catalano OA, Sahani DV. New and evolving concepts in the imaging and management of urolithiasis: urologists' perspective. Radiographics. 2010;30(3):603-23. https://doi: 10.1148/rg.303095146.
  • Alelign T, Petros B. Kidney stone disease: an update on current concepts. Adv Urol. 2018;2018:1–12. https://doi:10.1155/2018/3068365
  • Maalej B, Louati H, Abid H, Zitouni H, Weli M, et al. Pediatric Urolithiasis in Children: Diagnosis and Management. Med Sur Urol . 2017; 6: 196. https://doi:10.4172/2168-9857.1000196
  • VanDervoort K, Wiesen J, Frank R, Vento S, Crosby V, Chandra M, Trachtman H. Urolithiasis in pediatric patients: a single center study of incidence, clinical presentation and outcome. J Urol. 2007;177(6):2300-5. https://doi: 10.1016/j.juro.2007.02.002.
  • Dincel N, Resorlu B, Unsal A, et al. Are small residual stone fragments really insignificant in children? J Pediatr Surg. 2013;48:840-4. https://doi:10.5505/kjms.2015.80388
  • Strohmaier, Walter Ludwig. Imaging in pediatric urolithiasis-what's the best choice? Translational pediatrics. 2015; 4(1):36-40. https://doi:10.3978/j.issn.2224-4336.2015.01.01
  • Eray O, Cubuk MS, Oktay C, Yilmaz S, Cete Y, Ersoy FF. The efficacy of urinalysis, plain films, and spiral CT in ED patients with suspected renal colic. Am J Emerg Med. 2003; 21(2):152-4. https://doi: 10.1053/ajem.2003.50027.
  • Pfister SA, Deckart A, Laschke S, Dellas S, Otto U, Buitrago C, Roth J, Wiesner W, Bongartz G, Gasser TC. Unenhanced helical computed tomography vs intravenous urography in patients with acute flank pain: accuracy and economic impact in a randomized prospective trial. Eur Radiol. 2003; 13(11):2513-20. https://doi: 10.1007/s00330-003-1937-1.
  • Yilmaz S, Sindel T, Arslan G, Ozkaynak C, Karaali K, Kabaalioğlu A, Lüleci E. Renal colic: comparison of spiral CT, US and IVU in the detection of ureteral calculi. Eur Radiol. 1998;8(2):212-7. https://doi: 10.1007/s003300050364.
  • Sheir KZ, Mansour O, Madbouly K, Elsobky E, Abdel-Khalek M. Determination of the chemical composition of urinary calculi by noncontrast spiral computerized tomography. Urol Res. 2005;33(2):99-104. https://doi: 10.1007/s00240-004-0454-2.
  • Chateil JF, Rouby C, Brun M, Labessan C, Diard F. Mesure pratique de l'irradiation en radiopédiatrie: utilisation du produit dose surface en fluorographie numérique et pour les radiographies pulmonaires néonatales [Practical measurement of radiation dose in pediatric radiology: use of the dose surface product in digital fluoroscopy and for neonatal chest radiographs]. J Radiol. 2004;85(5 Pt 1):619-25. French. https://doi: 10.1016/s0221-0363(04)97638-x.
  • Kuhns LR, Oliver WJ, Christodoulou E, Goodsitt MM. The predicted increased cancer risk associated with a single computed tomography examination for calculus detection in pediatric patients compared with the natural cancer incidence. Pediatr Emerg Care. 2011;27(4):345-50. https://doi: 10.1097/PEC.0b013e3182132016.
  • Liu W, Esler SJ, Kenny BJ, Goh RH, Rainbow AJ, Stevenson GW. Low-dose nonenhanced helical CT of renal colic: assessment of ureteric stone detection and measurement of effective dose equivalent. Radiology. 2000;215(1):51-4. https://doi: 10.1148/radiology.215.1.r00ap4051.
  • Rogalla P, Klüner C, Taupitz M. Ultra-Niedrigdosis-CT zur Steinsuche in Nieren und ableitenden Harnwegen [Ultra-low-dose CT to search for stones in kidneys and collecting system]. Aktuelle Urol. 2004;35(4):307-9. German. https://doi: 10.1055/s-2004-830031.
  • Kolpakov IS.Urolithiasis: a guide for doctors. Moscow. Medical News Agency. 2014. 368 p.
  • Julka S, Gupta SK, Srivastava A. Protocol-based metabolic evaluation in high-risk patients with renal stones in North India. Indian J Endocrinol Metab. 2012;16(2):283-287. https://doi:10.4103/2230-8210.93754.
  • Ather MH, Noor MA. Does size and site matter for renal stones up to 30-mm in size in children treated by extracorporeal lithotripsy? Urology. 2003;61(1):212-215. https://doi: 10.1016/s0090-4295(02)02128-3.
  • Lottmann HB, Traxer O, Archambaud F, Mercier-Pageyral B. Monotherapy extracorporeal shock wave lithotripsy for the treatment of staghorn calculi in children. J Urol. 2001;165(6 Pt 2):2324-7. https://doi: 10.1097/00005392-200106001-00027. PMID: 11371942.
  • McAdams S, Shukla AR. Pediatric extracorporeal shock wave lithotripsy: Predicting successful outcomes. Indian J Urol. 2010; 26(4):544-548. https://doi:10.4103/0970-1591.74457
  • Tan AH, Al-Omar M, Watterson JD, Nott L, Denstedt JD, Razvi H. Results of shockwave lithotripsy for pediatric urolithiasis. J Endourol. 2004;18(6):527-30. https://doi: 10.1089/end.2004.18.527.
  • Demirkesen O, Onal B, Tansu N, Altintaş R, Yalçin V, Oner A. Efficacy of extracorporeal shock wave lithotripsy for isolated lower caliceal stones in children compared with stones in other renal locations. Urology. 2006;67(1):170-4; discussion 174-5. https://doi: 10.1016/j.urology.2005.07.061.
  • Onal B, Demirkesen O, Tansu N, Kalkan M, Altintaş R, Yalçin V. The impact of caliceal pelvic anatomy on stone clearance after shock wave lithotripsy for pediatric lower pole stones. J Urol. 2004;172(3):1082-6. https://doi: 10.1097/01.ju.0000135670.83076.5c.
  • Ozgür Tan M, Karaoğlan U, Sen I, Deniz N, Bozkirli I. The impact of radiological anatomy in clearance of lower calyceal stones after shock wave lithotripsy in paediatric patients. Eur Urol. 2003;43(2):188-93. https://doi: 10.1016/s0302-2838(02)00492-x.
  • Hwang K, Mason MD, Peters CA. Clinical practice: surgical approaches to urolithiasis in children. Eur J Pediatr. 2011;170(6):681-8. https://doi: 10.1007/s00431-010-1373-6.
  • Smaldone MC, Docimo SG, Ost MC. Contemporary surgical management of pediatric urolithiasis. Urol Clin North Am. 2010;37(2):253-67. https://doi: 10.1016/j.ucl.2010.03.006.
  • Salah MA, Toth C, Khan AM, Holman E. Percutaneous nephrolithotomy in children: experience with 138 cases in a developing country. World J Urol. 2004;22(4):277–280. https://doi: 10.1007/s00345-004-0454-4.
  • Lotan Y, Buendia Jiménez I, Lenoir‐Wijnkoop I, Daudon M, Molinier L, Tack I, Nuijten MJ. Increased water intake as a prevention strategy for recurrent urolithiasis: Major impact of compliance on cost‐effectiveness. Journal of Urology. 2013;189(3):935-939. https://doi: 10.1016/j.juro.2012.08.254
  • Borghi L, Meschi T, Maggiore U, Prati B. Dietary therapy in idiopathic nephrolithiasis. Nutr Rev. 2006;64(7 Pt 1):301-12. https://doi: 10.1301/nr.2006.jul.301-312.