Neurochemical disorders at the hypoxic-ischemic encephalopathy in newborns

Нейрохимические нарушения при гипоксически-ишемической энцефалопатии у новорожденных детей
Tamara Chuvakova 1, Bekturgan Karin 1
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1 Department of neonatology, National research center for maternal and child health of the corporate fund «UMC», Astana, Kazakhstan
J CLIN MED KAZ, Volume 3, Issue 45 special issue, pp. 141-144. https://doi.org/10.23950/1812-2892-JCMK-00514
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ABSTRACT

The article presents an image of the modern interpretation of the pathogenesis of hypoxic-ischemic encephalopathy in newborns, which later develops an understanding of the direction of therapeutic effects that provide a neuroprotective effect in a particular phase of the pathological process.
Keywords: energy insufficiency, exсitoxicity, neuroprotection, hypothermia

CITATION

Chuvakova T, Karin B. Neurochemical disorders at the hypoxic-ischemic encephalopathy in newborns. Journal of Clinical Medicine of Kazakhstan. 2017;3(45 special issue):141-4. https://doi.org/10.23950/1812-2892-JCMK-00514

REFERENCES

  • « Evropejskoe zdorov'e dlja vseh» (European health for all) Copenhagen, WHO Regional Office for Europe (http://data.euro.who. int/hfadb, accessed 23 March 2014).
  • American College of Obstetricians and Gynecologists and American Academy of Pediatrics: Background. Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology. Washington, DC: American College of Obstetricians and Gynecologists Distribution Center; 2003:1-11.
  • Task Force American College of Obstetricians and Gynecologists and TheAmerican Academy of Pediatrics. Neonatal encephalopathy and CP. Defining the pathogenesis and pathophysiology. Washington DC: ACOG. 2003.
  • Volpe JJ, Neurology of the Newborn, 5th ed. Philadelphia: Saunders Elsevier. 2008.
  • Lorek A, Takei Y and Cady EB, et al. Delayed (“secondary”) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994; 36: 699-706.
  • Laptook AR, Corbett RJ and Arencibia-Mireles O, et al.: Glucose-associated alterations in ischemic brain metabolism of neonatal piglets. Stroke. 1992; 23:1504-1511.
  • Johnston MV, Trescher WH, Ishida A, et al.: Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatr Res. 2001; 49: 735-741.
  • Fellman V and Raivio KO: Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res. 1997; 41: 599-606.
  • Liu XH, Kwon D and Schielke GP, et al.: Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxicischemic brain damage. J Cereb Blood Flow Metab. 1999; 19:1099-1108.
  • Gluckman PD, Guan J and Williams C., et al.: Asphyxial brain injury: the role of the IJF system. Mol Cell Endocrinol. 1998; 140: 95-99.
  • Gunn AJ, Gunn TR and de Haan HH, et al.: Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J Clin Invest. 1997; 99:248-256.
  • Gunn AJ, Gunn TR and Gunning MI, et al.: Neuroprotection with prolonged head cooling started before post-ischemic seizures in fetal sheep. Pediatrics. 1998; 102: 1098-1106.
  • Gunn AJ, Bennet L and Gunning MI, et al.: Cerebral hypothermia is not neuroprotective wen started after post-ischemic seizures in fetal sheep. 1999; 46: 274-280.
  • Caroll M and Beek O: Protection against hippocampal CA1 cell loss by post-ischemic hypothermia in dependent on delay of initiation and duration. Metab Brain Dis. 7:1992; 45-50.
  • Colbourne F and Corbett D: Delayed and prolonged post-ischemic hypothermia in neuroprotective in the gerbil. Brain Res. 654:1994; 265-272.
  • Colbourne F and Corbett D: Delayed and prolonged post-ischemic hypothermia: a six-month survival study using behavioral and histological assessments of neuroprotection. J Neurosci. 15: 1995; 7250-7260.