Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer

Hayriye Şahinli 1 * , Sema Türker 1
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1 Department of Medical Oncology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 4, Issue 54, pp. 34-39. https://doi.org/10.23950/1812-2892-JCMK-00724
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ABSTRACT

Objective: The prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index has been studied in many cancer types. Our aim is to show the prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index in resected gastric cancer patients. In addition, to determine which parameter is a better predictor of survival.
Material and methods: The study included 95 patients resected gastric cancer between 2014-2018. Receiver operating curve analysis was used to determine neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index cut-off values. Systemic immune-inflammatory index was evaluated as neutrophil × platelet/lymphocyte. Long rank and cox regression analysis were used.
Results: The median age was 62 (22-84) years. The median overall survival was 33 months. 49 (51.6%) patients were in stage 3 and 46 (48.4 %) patients were in stage 1-2. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index values, tumor depth, stage of metastatic lymph node and tumor-node-metastasis stage were poor prognostic factors for overall survival and disease-free survival. When multivariant cox regression analysis was performed, only platelet-lymphocyte ratio was found to be independent prognostic factor (p = 0.037 for overall survival, p = 0.024 for overall survival).
Conclusion: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index were found to be poor prognostic factors in predicting both overall survival and disease-free survival before treatment in patients who undergo curative resection for gastric cancer. As a result of multivariant analysis, only high platelet-lymphocyte ratio was determined as an independent poor prognostic factor for both overall survival and disease-free survival.
Keywords: gastric cancer, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, prognosis

CITATION

Şahinli H, Türker S. Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer. Journal of Clinical Medicine of Kazakhstan. 2019;4(54):34-9. https://doi.org/10.23950/1812-2892-JCMK-00724

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