Report of two cases with autoerythrocyte sensitization syndrome

Описание двух клинических случаев синдрома аутоэритроцитарной сенситизации
Hülya Nazik 1 * , Mehmet Kamil Mülayim 1, Perihan Öztürk 1, Ülkü Kazancı 2, İnci Dalyan Sarı 1
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1 Kahramanmaraş Sütçü İmam University, Department of Dermatology, Kahramanmaraş, Turkey
2 Kahramanmaraş Sütçü İmam University, Department of Pathology, Kahramanmaraş, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 4, Issue 50, pp. 40-43. https://doi.org/10.23950/1812-2892-JCMK-00632
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ABSTRACT

Auto-erythrocyte Sensitization Syndrome, also known as Gardner Diamond syndrome, is characterized by spontaneous painful and repetitive purpura. Here, we report two women aged 14 and 18 years who were diagnosed with auto-erythrocyte sensitization syndrome by typical laboratory, clinical, histopathological features and intradermal skin test. Burning and itching were the major complaints associated with spontaneous ecchymosis. The frequency of attacks in the patient using a specific serotonin re-uptake inhibitor due to migraine was significantly higher than the patient who did not receive psychiatric treatment. It was concluded that careful psychiatric evaluation is important for effective treatment of the disease.

CITATION

Nazik H, Mülayim MK, Öztürk P, Kazancı Ü, Sarı İD. Report of two cases with autoerythrocyte sensitization syndrome. Journal of Clinical Medicine of Kazakhstan. 2018;4(50):40-3. https://doi.org/10.23950/1812-2892-JCMK-00632

REFERENCES

  • Ivanov OL, Lvov AN, Michenko AV, Künzel J, Mayser P, Gieler U. Autoerythrocyte sensitization syndrome (Gardner-Diamond syndrome): review of the literature. J Eur Acad Dermatol Venereol. 2009; 23(5):499-504. https://doi.org/10.1111/j.1468-3083.2009.03096.x
  • Özuğuz P, Polat S, Kaçar SD. Autoerythrocyte  Sensitization Syndrome: A Case Report. Clin Anal Med. 2014; 5 (suppl 2):160-2.
  • Gardner F, Diamond L. Autoerythrocyte sensitization: a form of purpura producing painful bruising following autosensitization to red blood cells in certain women. Blood. 1995; 10:675-690.
  • Block ME, Sitenga JL, Lehrer M, Silberstein PT. Gardner-Diamond syndrome: a systematic review of treatment options for a rare psychodermatological disorder.  Int J Dermatol. 2018 Sep 20. https://doi.org/10.1111/ijd.14235
  • Tainwala RR, Phiske M, Raghuwanshi A, Mathapati S, Manjare AK, Jerajani HR. Perplexing purpura in two females: Rare case of autoerythrocyte sensitization syndrome. Indian Dermatol Online J. 2013;4(4):305-8. https://doi.org/10.4103/2229-5178.120650
  • Durmazlar SP, Atacan D, Cemil B, Eskioglu F. Is Gardner-Diamond syndrome associated with hormonal influences along with psychosocial problems? A delayed diagnosis. Eur J Dermatol. 2009; 19(3):259-60. https://doi.org/10.1684/ejd.2009.0624
  • Kavala M, Südoğan S, Büyük AY, Aksakal A, Sarıgül Ş, Eskiçırak B. Autoerythrocyte sensitization syndrome: Gardner-Diamond syndrome. Turkderm. 2003; 37:120-123.