Rivaroxaban induced spontaneous hemoperitoneum around terminal ileum and cecum clinically mimicking acute appendicitis in a young patient: First case report

Ibrahim Halil Inanc 1 * , Saadet Kılıc 2, Murat Polat 3
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1 Department of Cardiology, Besni State Hospital, Adiyaman, Turkey
2 Department of General Surgery, Besni State Hospital, Adiyaman, Turkey
3 Department of Radiology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 2, Issue 56, pp. 50-52. https://doi.org/10.23950/1812-2892-JCMK-00756
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ABSTRACT

Direct oral anticoagulants have become more popular in recent years and have largely replaced vitamin K antagonists in the treatment of certain conditions, such as stroke prevention in atrial fibrillation and venous thromboembolism. Rivaroxaban is one of the direct oral anticoagulants that inhibit factor Xa and a rare cause of peritoneal haemorrhage which is uncommon and life-threatening complication. In this report, we present a 29-year-old female patient using rivaroxaban due to deep vein thrombosis after pregnancy and developing intraperitoneal hemorrhage around terminal ileum and cecum clinically mimicking acute appendicitis.
Keywords: rivaroxaban, intraperitoneal hemorrhage, acute appendicitis

CITATION

Inanc IH, Kılıc S, Polat M. Rivaroxaban induced spontaneous hemoperitoneum around terminal ileum and cecum clinically mimicking acute appendicitis in a young patient: First case report. Journal of Clinical Medicine of Kazakhstan. 2020;2(56):50-2. https://doi.org/10.23950/1812-2892-JCMK-00756

REFERENCES

  • Beyer-Westendorf J, Förster K, Pannach S, Ebertz F, Gelbricht V, Thieme C, et al. Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry. Blood, The Journal of the American Society of Hematology. 2014; 124(6):955-62. https://doi.org/10.1182/blood-2014-03-563577
  • Di Minno A, Frigerio B, Spadarella G, Ravani A, Sansaro D, Amato M, et al. Old and new oral anticoagulants: food, herbal medicines and drug interactions. Blood Reviews. 2017; 31(4):193-203. https://doi.org/10.1016/j.blre.2017.02.001
  • Mueck W, Stampfuss J, Kubitza D, Becka M. Clinical pharmacokinetic and pharmacodynamic profile of rivaroxaban. Clinical pharmacokinetics. 2014; 53(1):1-16. https://doi.org/10.1007/s40262-013-0100-7
  • Cheung K-S, Leung WK. Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management. World journal of gastroenterology. 2017; 23(11):1954. https://doi.org/10.3748/wjg.v23.i11.1954
  • Douxfils J, Ageno W, Samama CM, Lessire S, Ten Cate H, Verhamme P, et al. Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians. Journal of Thrombosis and Haemostasis. 2018; 16(2):209-19. https://doi.org/10.1111/jth.13912
  • Investigators E. Oral rivaroxaban for symptomatic venous thromboembolism. New England Journal of Medicine. 2010; 363(26):2499-510. https://doi.org/10.1056/NEJMoa1007903
  • Naseem Z, Mustaev M, Strekozov B. Spontaneous splenic rupture secondary to rivaroxaban: Rare but raising. IJSM. 2016; 2:134-6. https://doi.org/10.5455/ijsm.spleenrupture
  • Krause M, Henningsen A, Torge A, Juhl D, Junker R, Kenet G, et al. Impact of gender on safety and efficacy of Rivaroxaban in adolescents & young adults with venous thromboembolism. Thrombosis research. 2016; 148:145-51. https://doi.org/10.1016/j.thromres.2016.09.007
  • Sherrod BA, Condie CK, Brock AA, Ledyard H, Menacho ST, Mazur MD. Emergent Reversal of Direct Oral Anticoagulants Permitting Neurosurgical Intervention for Nonhemorrhagic Pathology. World Neurosurgery. 2020; 135:38-41. https://doi.org/10.1016/j.wneu.2019.11.162