Screening for early lung cancer detection with the low-dose computer tomography

Скрининг раннего рака легкого методом низко-дозной компьютерной томографии
Gulziya Ismailova 1, Raushan Rakhimzhanova 2
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1 National Scientific Medical Research Center, Astana city, Kazakhstan
2 Astana Medical University, Astana city, Kazakhstan
J CLIN MED KAZ, Volume 2, Issue 32, pp. 21-25.
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ABSTRACT

Lung cancer (LC) is the main reason of cancer mortality at around the world.  Shortage of clinical signs of an early stage often leads to diagnostics of LC at late stage.  Current of LC is aggravated by smoking factor which promotes cancer development with heavy KRAS mutation.  LC with KRAS mutation has very bad prognosis, a treatment strategy is only standard, and effective treatment of cancer with KRAS mutation are absent in the world. Overall survival rate is 2-6 months from beginning the clinical manifestations. The only opportunity to increase of the overall survival rate at patient’s cohort is detection of LC at early stage, before clinical manifestations.  Low-dose computer tomography is the most effective screening method for diagnostics of early LC.
Keywords: screening, lung cancer, low-dose computer tomography, circulating tumour cells
Өкпе обыры (ӨО) – бүкіл əлемде обырдан болатын өлім-жітімнің негізгі себебі. Ауруды ерте деңгейінде клиникалық белгілерінің жетіспеушілігі өкпе обырын ең соңғы деңгейінде диагностикалауға жиі соқтырады. Өкпе обыры ағымының ауырлығы шылым шегу факторымен ұлғайтылады, ол ауыр KRAS өзгерумен обырдың дамуына əсер етеді. Өкпе обыры KRAS өзгерумен болжамы өте жаман, стандартты түрдегі химиятерапиямен емдеу, өзгерудің аталмыш түрін емдеудің нəтижелі əдістері бүкіл əлемде əлі жоқ, осындай науқастардың орташа өмір ұзақтығы клиникалық белгілері пайда болу мерзімінен кейін 2-6 ай. Бұл науқастардың өмір ұзақтығын ұзартудың жалғыз мүмкіндігі – ол обырды ерте мерзімінде, клиникалық белгілеріне дейін, анықтау. Төменгі мөлшердегі компьютерлік томография бүкіл əлемде ерте деңгейінде өкпе обырын диагностикалаудың ең нəтижелі скринингтік тəсілі болуда.
Keywords: скрининг, өкпе обыры, төменгі мөлшердегі компьютерлік томография, қан тамырларында айналып жүретін обыр жасушалары

CITATION

Ismailova G, Rakhimzhanova R. Screening for early lung cancer detection with the low-dose computer tomography. Journal of Clinical Medicine of Kazakhstan. 2014;2(32):21-5.

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