Soluble and Cellular Inflammatory Predictive Markers Associated with Recurrent Pregnancy Loss Among Kazakhstani Women: a Pilot Study

Damira Shertay 1, Gulzhanat Aimagambetova 2, Abay Tursunov 1, Talshyn Ukybassova 3, Aizada Marat 4, Madina Sharipova 4, Wassim Y. Almawi 5 6, Kuralay Atageldiyeva 7 8 *
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1 School of Medicine, Nazarbayev University, Astana, Kazakhstan
2 Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan
3 Clinical Academic Department of Women's Health, CF “University Medical Center”, Astana, Kazakhstan
4 Department of Obstetrics and Gynecology #1, NJSC “Astana Medical University”, Astana, Kazakhstan
5 Department of Biological Sciences, Brock University, St.Catharines, Ontario, Canada
6 Science Faculty of Tunisia, Université de Tunis El Manar, Tunis, Tunisia
7 Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
8 Clinical Academic Department of Internal Medicine, CF "University Medical Center", Astana, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 5, pp. 15-20. https://doi.org/10.23950/jcmk/15142
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Author Contributions: Conceptualization, G. A., K. A., W. Y. A; methodology, G. A., K. A., W. Y. A;  data collection, T. U., M. S., A. T., A. M.;  software, A. T., D. S., W. Y. A.; data analysis, D. S., W. Y. A.; visualization, D. S., W. Y. A., K. A., T. U., A. M., M. S.; drafting of paper, G. A., D. S., W. Y. A., K. A. All authors have read and agreed to the published version of the manuscript.

Ethical Considerations: This study received approval from the Nazarbayev University Institutional Research Ethics Committee (NU-IREC) on 29/09/2022, #599/05092022. All study participants were informed about the study aims, methods, and potential risks and benefits. A consent form was introduced and taken from all study subjects of this research study.

ABSTRACT

Background: Recurrent pregnancy loss (RPL) is a common complication of pregnancy globally, characterized by multiple miscarriages but with poorly explained etiologies. Insofar as a state of low-grade inflammation (LGI) accompanies RPL, this study explores the link between RPL and markers of LGI among Kazakhstani women.
Methods: The retrospective study was conducted on 112 Kazakh women, comprising 64 with a confirmed diagnosis of RPL and 48 women with two or more uncomplicated pregnancies serving as controls. Statistical analysis was performed on SPSS 29 software.
Results: All tested blood analytes, including CRP, glucose, cholesterol, LDL-cholesterol, Hemoglobin, and RBC counts, were negatively associated with RPL. The only exception was neutrophil values having a positive association with RPL despite a lack of significant correlation between groups.
Conclusion: The study shows a marginal association between the LGI biomarkers considered and the overall risk factors of RPL in Kazakh women, which is in apparent contradiction with earlier studies. The absence of parallel studies in Central Asian countries hampers the analysis of study trends in related communities. Future case-control studies with more sample sizes are needed to explore the RPL biomarkers in depth.
Keywords: recurrent pregnancy loss, low grade inflammation, recurrent miscarriages, RPL markers, Kazakhstan

CITATION

Shertay D, Aimagambetova G, Tursunov A, Ukybassova T, Marat A, Sharipova M, et al. Soluble and Cellular Inflammatory Predictive Markers Associated with Recurrent Pregnancy Loss Among Kazakhstani Women: a Pilot Study. J CLIN MED KAZ. 2024;21(5):15-20. https://doi.org/10.23950/jcmk/15142

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