Stem cells therapy in inflammatory bowel disease

Применение стволовых клеток в лечении воспалительных заболеваний кишечника
Venera Rakhmetova 1, Aida Orazbayeva 1
More Detail
1 Department of Gastroenterology and Hepatology, JSC “National Scientific Medical Center”, Astana, Kazakhstan
J CLIN MED KAZ, Volume 4, Issue 46, pp. 6-10. https://doi.org/10.23950/1812-2892-JCMK-00463
OPEN ACCESS 3684 Views 2703 Downloads
Download Full Text (PDF)

ABSTRACT

The article analyzes the experience of applying various stem cell pools in the treatment of inflammatory diseases of the colon. Basic and clinical studies on properties of mesenchymal stem cells and clinical effects of various technologies for their use conducted held in recent years allows to consider the mesenchymal stem cells transplantation as a new and promising direction in the treatment of ulcerative colitis.
Keywords: inflammatory bowel disease, mesenchymal stem cell, transplantation, regenerative medicine

CITATION

Rakhmetova V, Orazbayeva A. Stem cells therapy in inflammatory bowel disease. Journal of Clinical Medicine of Kazakhstan. 2017;4(46):6-10. https://doi.org/10.23950/1812-2892-JCMK-00463

REFERENCES

  • Khalif I.L., Loranskaya I.D., Vospalitel’nye zabolevaniya kishechnika (nespetsificheskii yazvennyi koliti, bolezn’ Krona): klinika, diagnostika, lechenie (Inflammatory bowel disease (ulcerative colitis and Crohn’s disease): clinic, diagnosis, treatment) [inRussian]. M: Miklosh. 2004;pp. 88.
  • Adler G. Bolezn’ Krona I yazvennyi kolit (Crohn’s disease and ulcerative colitis) [in Russian].M: GEOTAR-MED. 2001;pp. 527.
  • Vorob’ev G.I., Khalif I.L. Nespetsificheskie vospalitel’nye zabolevaniya kishechnika (Nonspecific inflammatory bowel disease) [in Russian]. M: Miklosh. 2008; pp 400.
  • Belousova E.A. Yazvennyi kolit i bolezn’ Krona (Ulcerative colitis and Crohn’s disease) [in Russian]. Tver’: Izdatel’stvo «Triada».2002; pp128.
  • Gomollón F, Dignass A, Annese V, Tilg H, Van Assche G, Lindsay JO, Peyrin-Biroulet L, Cullen GJ, Daperno M, Kucharzik T, Rieder F. 3rd European evidence-based consensus on the diagnosis and management of Crohn’s disease 2016: part 1: diagnosis and medical management. Journal of Crohn’s and Colitis. 2016;11(1):3-25.
  • Harbord M, Eliakim R, Bettenworth D, Karmiris K, Katsanos K, Kopylov U, Kucharzik T, Molnár T, Raine T, Sebastian S, de Sousa HT. Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management. Journal of Crohn’s and Colitis. 2017; 1–24.
  • Mowat C, Cole A, Windsor A, Ahmad T, Arnott I, Driscoll R, Mitton S, Orchard T, Rutter M, Younge L, Lees C. Guidelines for the management of inflammatory bowel disease in adults. Gut. 2011;60(5):571-607.
  • Peyrin-Biroulet L, Bouhnik Y, Roblin X, Bonnaud G, Hagège H, Hébuterne X. French national consensus clinical guidelines for the management of ulcerative colitis. Digestive and Liver Disease. 2016;48(7):726-33.
  • Satsangi J. Morecroft N.B. Genetics of inflammatory bowel disease: scientific and clinical implications. Best Pract. Res. Clin. Gastroenterology.2003;17:3-18.
  • Yamamoto-Furusho JK, Podolsky DK. Innate immunity in inflammatory bowel disease. World journal of gastroenterology. 2007;13(42):5577.
  • Farell R., Pepperkorn M. Yazvennyikolit (Ulcerative colitis) [in Russian], Mezhdunarodnyi meditsinskii zhurnal.2003;1(6): http://medi.ru/doc/773012.htm.
  • Munkholm P, Langholz E, Davidsen M, Binder V. Frequency of glucocorticoid resistance and dependency in Crohn9s disease. Gut. 1994 Mar 1;35(3):360-2.
  • Faubion WA, Loftus EV, Harmsen WS, Zinsmeister AR, Sandborn WJ. The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study. Gastroenterology. 2001;121(2):255-60.
  • Kalinina N. I., Sysoeva V. Yu., Rubina K. A., Parfenova E. V., Tkachuk V.A. Annotatsiya nauchnoi stat’i «Mezenkhimal’nye stvolovye kletki v protsessa khrostaireparatsi i tkanei» (Mesenchymal stem cells in tissue growth and repair processes) [in Russian]. Acta Naturae. 2011;3(4).
  • Ditschkowski M, Einsele H, Schwerdtfeger R, Bunjes D, Trenschel R, Beelen DW, Elmaagacli AH. Improvement of inflammatory bowel disease after allogeneic stem-cell transplantation. Transplantation. 2003 May 27;75(10):1745-7.
  • Oyama Y, Craig RM, Traynor AE, Quigley K, Statkute L, Halverson A, Brush M, Verda L, Kowalska B, Krosnjar N, Kletzel M. Autologous hematopoietic stem cell transplantation in patients with refractory Crohn’s disease. Gastroenterology. 2005;128(3):552-63.
  • Cassinotti A, Annaloro C, Ardizzone S, Onida F, Della Volpe A, Clerici M, Usardi P, Greco S, Maconi G, Porro GB, Deliliers GL. Autologous haematopoietic stem cell transplantation without CD34+ cell selection in refractory Crohn’s disease. Gut. 2008;57(2):211-7.
  • Dryden G.W. Overview of stem cell therapy for Crohn disease. Expert. Opin. Biol. Ther. 2009;9:841–847.
  • Burt R.K., Traynor A., Oyama Y., Craig R. High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease. Blood. 2003;101:2064–2066.
  • Nasadyuk CM. Stem Cell Therapy In The Treatment Of Inflammatory Bowel Disease. Gastroenterology&Hepatology: Open Access. 2014;1(1):00006. 
  • I.V. Mayanskaya, A.Yu. Goganova, N.I. Tolkachova, V.I. Achkinazi, A.N. Mayansky. Immunosuppressive activity of mesenchymal stem (stromal) cells [In Russian]. Immunology. 2013;34(2):122-128
  • Hawkey C. J. Stem cell transplantation for Crohn’s disease. Best Pract Res Clin. Haematol.2004;17(2):317-325.
  • Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Blood. 1995;86(5):2041-50.
  • McGuire WP, Hoskins WJ, Brady MF, Kucera PR, Partridge EE, Look KY, Clarke-Pearson DL, Davidson M. Cyclophosphamkte and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N. Engl. J. Med. 1996;334(1):1-6.
  • Nasonov E. L. Sovremennye napravleniya immunologicheskikh issledovanii pri khronicheskikh vospalitel’nykh i autoimmunnykh zabolevaniyakh cheloveka (Modern trends of immunological studies in chronic inflammatory and autoimmune diseases of man) [in Russian]. Ter. arkhiv. 2001;73(8):43— 46.
  • Nazarenko G. I., Kishkun A. A. Klinicheskaya otsenka rezul’tatov laboratornykh issledovanii (Clinical evaluation of laboratory results) [in Russian]. M.: Meditsina. 2002; pp 544.
  • Shevchenko Yu. L., Boitsov S. A., Novik A. A., Lyadov K. V. Kontseptsiya kletochnoi terapii autoimmunnykh zabolevanii (The concept of cell therapy of autoimmune diseases) [in Russian]. Vestn.Ros. AMN.2004;9:40-4.
  • Singh UP, Singh NP, Singh B, Mishra MK, Nagarkatti M, Nagarkatti PS, Singh SR. Stem cells as potential therapeutic targets for inflammatory bowel disease. Frontiers in bioscience (Scholar edition). 2010;1:993–1008.
  • Lazebnik L.B., Knyazev O.V., Konoplyannikov A.G. i dr. Allogennye mezenkhimal’nye stromal’nye kletki v lechenii bol’nykh yazvennym kolitom: dva goda nablyudeniya (Allogenic mesenchymal stromal cells in the treatment of patients with ulcerative colitis: two years of follow-up) [in Russian]. Klin.eksperiment. gastroenterol.2010;11:3–15.