STRUCTURAL AND FUNCTIONAL FEATURES OF POLYMORPHIC LOCI OF BRCA1 AND BRCA2 GENES IN THE ENDOMETRIAL CANCER

СТРУКТУРНО-ФУНКЦИОНАЛЬНЫЕ ОСОБЕННОСТИ ПОЛИМОРФНЫХ ЛОКУСОВ ГЕНОВ BRCA1 И BRCA2 ПРИ РАКЕ ЭНДОМЕТРИЯ
Ж. К. Чингисова
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J CLIN MED KAZ, Volume 3, Issue 29, pp. 47-50.
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ABSTRACT

The researches dedicate to search the structuralfunctional futures of genomes for prognosis of effectiveness of treatment endometrial cancer by conducting with molecular-genetic methods/ In result the work we detected of BRCA1 gene polymorphism at codon 356, 502, 1655 are representative based polymorphism and could perform as effectiveness genetic marker in determine of predisposition risk of tumor genesis in population-family history of diseases.
The presence 4553delA, 2683TTGAT of BRCA1 gene may correspond to different degrees of histological malignancy.
Keywords: oncogynecological cancer, with uterine cancer, the survival rate of patients with cancer, prognostic factors, molecular markers

CITATION

Чингисова ЖК. STRUCTURAL AND FUNCTIONAL FEATURES OF POLYMORPHIC LOCI OF BRCA1 AND BRCA2 GENES IN THE ENDOMETRIAL CANCER. Journal of Clinical Medicine of Kazakhstan. 2013;3(29):47-50.

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