Sudden infant death syndrome as a result of thymic-lymphatic dysgenesis
Saule Amangeldievna Mussabekova 1 * ,
Elena Igorevna Burkova 1 * ,
Kristina Ergardovna Dobler 2,
Balzhan Smailovna Muldasheva 2,
Zhan Zhumagulovich Atmtaev 2 More Detail
1 Department of Morphology, Medical University of Karaganda, Karaganda, Kazakhstan
2 Institute of Forensic Examinations in Karaganda, Center for Forensic Examination of the Ministry of Justice of the Republic of Kazakhstan, Karaganda, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 1, pp. 97-100.
https://doi.org/10.23950/jcmk/14266
OPEN ACCESS
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Author Contributions
Conceptualization, S. M.; methodology, K. D.; validation, B. M.; formal analysis, B. M.; investigation, Zh. A.; resources, K. D.; data curation, Е. B.; writing – original draft preparation, Е. B.; writing – review and editing, S. M.; visualization, K. D.; supervision, S. M.; project administration, S. M.; funding acquisition – not applicable. All authors have read and agreed to the published version of the manuscript.
ABSTRACT
Sudden infant death syndrome is one of the leading causes of post-neonatal mortality. The thymic-lymphatic condition in children is a clinically rare manifestation and difficult to diagnose condition, assessed as a background, realized in a number of cases of sudden death syndrome. However, the clinical and histopathological manifestations of thymic-lymphatic status may not be clearly expressed. We present an unusual case of sudden infant death syndrome as a result of thymic-lymphatic dysgenesis complicated by acute adrenal insufficiency.
CITATION
Mussabekova SA, Burkova EI, Dobler KE, Muldasheva BS, Atmtaev ZZ. Sudden infant death syndrome as a result of thymic-lymphatic dysgenesis. J CLIN MED KAZ. 2024;21(1):97-100.
https://doi.org/10.23950/jcmk/14266
REFERENCES
- Vincent A, Chu NT, Shah A, Avanthika C, Jhaveri S, Singh K, Limaye OM, Boddu H. Sudden Infant Death Syndrome: Risk Factors and Newer Risk Reduction Strategies. Cureus. 2023; 15(6): e40572. https://doi.org/10.7759/cureus.40572.
- Gras-Le Guen C, Franco P, Plancoulaine S. Editorial: Sudden infant death syndrome: Moving forward. Front. Pediatr. 2022; 10: 972430. https://doi.org/10.3389/fped.2022.972430.
- Mussabekova S, Stoyan A. The case of determining the species, gender, age and race of the skull with congenital multiple developmental anomalies. J CLIN MED KAZ. 2022; 19(1): 80-4. https://doi.org/10.23950/jcmk/11682.
- Khan MA, Anjum F. Thymic Hyperplasia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2023.
- Grassi S, Pinchi V, Campuzano O, Oliva A, Brugada R. Editorial: Genetics of sudden unexplained death in children and young adults: state of the art, testing and implications for translational research, public health and forensic pathology. Front. Med. 2023; 10: 1309179. https://doi.org/10.3389/fmed.2023.1309179.
- Karataeva LA. Sindrom vnezapnoj smerti i ego sovremennye aspekty [in Russian]. Medicus. 2020; 3(33): 68-70.
- Zakharov MV, Fedulova MV, Pigolkin YuI. Sudden death in school-aged children at physical exercise: forensic diagnosis. Sudebno-Meditsinskaya Ekspertisa. 2021; 64(4): 64–67. https://doi.org/10.17116/sudmed20216404164.
- Claes L, Dendooven A, van Heerden J. Challenges in diagnosing ectopic thymus tissue in children. BMJ Case Rep. 2019;12(9):e228807. https://doi.org/10.1136/bcr-2018-228807.
- Varga I, Bódi I, Mešťanová V, Kováč M, Klein M. Association between histological alterations in the thymus and sudden infant death syndrome. J Forensic Leg Med. 2018; 55: 8-13. https://doi.org/10.1016/j.jflm.2018.02.007.
- Byard RW. Thymic changes and sudden infant death syndrome (SIDS). J Forensic Leg Med. 2019; 61: 141. https://doi.org/10.1016/j.jflm.2018.09.004.
- Avanesjan HA, Berlaj MV, Kopylov AV, Korobkeev AA, Karpov SM. Sudebno-medicinskaja diagnostika morfologicheskih izmenenij pri sindrome vnezapnoj detskoj smerti [in Russian]. Medicinskij vestnik Severnogo Kavkaza. 2018; 13(4): 667-671.
- Qu D, Preuss V, Hagemeie L. Radomsky L, Beushausen K, Keil J, et al. Age-related cytokine imbalance in the thymus in sudden infant death syndrome (SIDS). Pediatr Res. 2023. https://doi.org/10.1038/s41390-023-02809-6.
- Tolstova EM, Zajceva OV. Fiziologija i patologija timusa v detskom vozraste [in Russian]. Pediatrija. Zhurnal im. G. N. Speranskogo. 2018; 97 (6): 166-172.
- Guleria P, Jain D. Thymic lesions of the paediatric age group: a comprehensive review of non-neoplastic and neoplastic etiologies. Mediastinum. 2019; 3: 24. https://doi.org/10.21037/med.2019.05.04.
- Borisenko NS, Popugajlo MV. Timiko-limfaticheskij status kak istoricheskij fenomen v medicine [in Russian]. Vestnik UGMU. 2023; 2: 62-72.
- Weis CA, Märkl B, Schuster T, Vollert K, Ströbel P, Marx A. True thymic hyperplasia: Differential diagnosis of thymic mass lesions in neonates and children. Pathologe. 2017; 38(4): 286-293. https://doi.org/10.1007/s00292-017-0283-z.
- Mlika M, Yaiche R, Fourti A, Braham E, Houcin Y, Marghli A, Mezni F. Thymic hyperplasia: A study of 46 cases. Ann Pathol. 2021; 41(6): 544-548. https://doi.org/10.1016/j.annpat.2021.01.003.
- Benevento M, Nicolì S, Ferorelli D. Sudden cardiac death and thymic hyperplasia in adults: myth or reality? A case report. Egypt J Forensic Sci. 2023; 13: 37. https://doi.org/10.1186/s41935-023-00357-y.
- Tsuda T, Fitzgerald KK, Temple J. Sudden cardiac death in children and young adults without structural heart disease: a comprehensive review. Rev. Cardiovasc. Med. 2020; 21(2): 205-216. https://doi.org/10.31083/j.rcm.2020.02.55.
- Serfilippi LM, Quance JL. Pathology in Practice. J Am Vet Med Assoc. 2018; 253(2): 173-176. https://doi.org/10.2460/javma.253.2.173.
- Chen C, Zhang C, Deng Y, Du S, Wang H, Li D. Thymic hypoplasia induced by copy number variations contributed to explaining sudden infant death based on forensic autopsies. Forensic Sci Int. 2022; 336: 111323. https://doi.org/10.1016/j.forsciint.2022.111323.
- Zou L, Zhang Y, Zhu R. Thymic Hypertrophy and Sudden Unexpected Death in Adults – A Retrospective Study Of 56 Autopsy Cases. International Journal of Human Anatomy. 2017; 1(1): 9-20. https://doi.org/10.14302/issn.2577-2279.ijha-17-1538.
- Bhalla P, Su DM, van Oers NSC. Thymus Functionality Needs More Than a Few TECs. Front Immunol. 2022; 13: 864777. https://doi.org/10.3389/fimmu.2022.864777.
- Yang M, Zeng L, Ji Y, Xiang B, Xu ZC. Massive true thymic hyperplasia in a 3-month-old infant: case report and literature review. Turk J Pediatr. 2021; 63(4): 721-726. https://doi.org/10.24953/turkjped.2021.04.022.
- Jiao J, Yu J, Chen C, Chen T, Zheng T, He L, Zeng Q. Thoracoscopic approach for massive thymic hyperplasia in an infant: Case report and literature review. Front Pediatr. 2023; 11: 1144384. https://doi.org/10.3389/fped.2023.1144384.