The effect of aсtive hexose correlated compound on (multi) nodular euthyroid goiter: A double-blind placebo-controlled study

Zaure Zhaparkhanova 1 * , Bayan Zhumanova 2, Aziza Alipova 2, Aizat Aimakhanova 3, Sholpan Eslamgalieva 4, Anel Kurmanova 1, Zhazira Nurlykaimova 1, Michael Zeltser 1, Assym Akyshbayev 1
More Detail
1 Center of Neuroendocrinology, Almaty, Republic of Kazakhstan
2 Department of Endocrinology, JSC Kazakh National Medical University named after S.D.Asfendiyarova, Almaty, Kazakhstan
3 Department of Biostatistics and Basic of Scientific Research, S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
4 Department of Molecular Biology and Medical Genetics, S.D.Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 18, Issue 2, pp. 66-71. https://doi.org/10.23950/jcmk/10803
OPEN ACCESS 2806 Views 1221 Downloads
Download Full Text (PDF)

ABSTRACT

Aim: of the study is to evaluate the effectiveness of Аctive Hexose Correlated Compound (АНСС®) use in monotherapy and its impact on the echographic characteristics of the thyroid gland during (multi) nodular goiter.
Methods: The study involved 27 people with (multi) nodular euthyroid goiter. The main treatment group consisted of 13 patients who received АНСС®. The placebo control group consisted of 14 participants. The duration of the drug intake lasted for 100 days. Three visiting schedules were arranged including initial, intermediate and final visits. Research methods included clinical examinations, laboratory tests, a thyroid ultrasound (classification by K-TIRADS) and completing a questionnaire.
Results: The laboratory tests confirmed the euthyroid status of patients in both groups at baseline and at the end of the study. A decrease in the total volume of the right and left lobes of the thyroid gland was noted among the main treatment group. In addition, a decrease in the volume of all types of nodules was seen in this group. A decrease in the volume of the type 2 colloid node was statistically significant. On the contrary, a statistically significant increase in the average volume of the same type of node among the control group was seen. Overall, the average volume of the node decreased by 37.2% in the main group and increased by 4.9% in the control group by the end of the study.
Conclusion: The results of this double-blind, placebo-controlled study make it possible to assess the efficiency of АНСС® in (multi) nodular goiter affecting primarily the volume of nodes (mainly of the 2nd and 3rd types). This is especially important when a potential surgery or radioiodine therapy may carry a high risk of complications among patients.
Keywords: (multi) nodular euthyroid goiter, ultrasound, Thyroid Image Reporting and Data System, Аctive Hexose Correlated Compound (AHCC)

CITATION

Zhaparkhanova Z, Zhumanova B, Alipova A, Aimakhanova A, Eslamgalieva S, Kurmanova A, et al. The effect of aсtive hexose correlated compound on (multi) nodular euthyroid goiter: A double-blind placebo-controlled study. J CLIN MED KAZ. 2021;18(2):66-71. https://doi.org/10.23950/jcmk/10803

REFERENCES

  • Balabolkin M.I., Klebanova E.M., Kreminskaja V.M. Fundamental'naja i klinicheskaja tiroidologija (Fundamental and Clinical Thyroidology) [in Russian] М, 2007. 816 p.
  • Valdina E.A. Zabolevanija shhitovidnoj zhelezy: Rukovodstvo (Thyroid Disorders: A Guide) [in Russian]. 3th ed. Spb, 2006, 368 p.
  • Jendokrinologija. Nacional'noe rukovodstvo. Kratkoe izdanie (Endocrinology. National leadership. Short edition) [in Russian] /pod red. I.I.Dedova, G.A.Mel'nichenko.2-е изд. М, 2018. 832 p.
  • Horvath E, Majlis S, Rossi R, Franco C, Niedmann J.P., Castro A. et al. An ultrasonogram reporting system for thyroid nodules stratifying cancer risk for clinical management. The Journal of Clinical Endocrinology&Metab. 2009; 94(5):1748-1751.
  • Kwak J.Y., Han K.H., Yoon J.H., Moon H.J., Son E.J., Park S.H. et al. Thyroid imaging reporting and data system for US features of nodules: a step in establishing better stratification of cancer risk. Radiology. 2011; 260(3): 892-899.
  • Shi Yi-Xin, Chen Lin, Liu Ying-Chun, Zhan Jia, Diao Xue-Hong, Fang Liang et al. Differences among the Thyroid Imaging Reporting and Data System proposed by Korean, the American College of Radiology and the European Thyroid Assosiation in the diagnostic performance of thyroid nodules. Translational Cancer Research, 2020; 9(8): 4958-4967. Doi:10.21037/tcr-19-2870
  • Schenke S., Klett R., Seifert P., Kreissl MC, Gorges R., Zimny M. Diagnostic Performance of Different Thyroid Imaging Reporting and Data Systems (Kwak-TIRADS, EU-TIRADS and ACR TIRADS) for the Risk Stratification of Small Thyroid Nodules (≤10 mm). Journal of Clinical Medicine, 2020, 9(1). DOI:10.3390/jcm9010236
  • Klinicheskij protokol diagnostiki i lechenija «Uzlovoj zob u vzroslyh» (Clinical protocol for diagnosis and treatment “Nodular goiter in adults”) [in Russian], RCRZ, protokol № 8 ot 13.07.2016. www.rcrz.kz.
  • Rossijskie klinicheskie rekomendacii. Jendokrinologija (Russian clinical guidelines. Endocrinology) [in Russian] /pod red. I.I.Dedova, G.A.Mel'nichenko. М, 2019. 592 p.
  • Clinician’s Guide to AHCC®/ edited by Kulkarni AD, Calder P, Ito T. Published by ICNIM, Hokkaido, 2017. 300 p.
  • Shin Min Sun, Park Hong-Jai, Maeda Takahiro, Nishioka Hiroshi, Hajime Fujii, Insoo Kang The Effects of AHCC ®, a Standardized Extract of Cultured Lentinula edodes Mycelia, on Natural Killer and T Cells in Health and Disease: Reviews on Human and Animal Studies. Journal of Immunology Research. 2019, https://doi.org/10.1155/2019/3758576
  • Rebrova O.Ju. Statisticheskij analiz medicinskih dannyh. Primenenie paketa prikladnyh programm STATISTICA (Statistical analysis of medical data. Using the STATISTICA Application Package) [in Russian] М, 2002, 312 p.
  • Fletcher R., Fletcher S., Vagner Je. Klinicheskaja jepidemiologija: Osnovy dokazatel'noj mediciny (Clinical Epidemiology: Basics of Evidence-Based Medicine) [in Russian] М, 1998. 352 p.
  • Ul'trazvukovoe issledovanie shhitovidnoj zhelezy (Thyroid ultrasound) [in Russian] /red.: G.Dzhek Bjeskin-st., Djeniel S. Djuik, Robert Je.Levin. М, 2018. 432 p.
  • Grussendorf M, Reiners C, Paschke R, Wegscheider K. Reduction of thyroid nodule volume by levothyroxine and jodine alone and in combination: A randomized, placebo-controlled trial. J Clin Endocrinol Metab. 2011; 96: 2786-95
  • Baldini, M; Gallazzi, M; Orsatti, A; Fossati, S; Leonardi, P; Cantalamessa L. Treatment of benign nodular goiter with mildly suppressive doses of L-thyroxine: effects on bone mineral density and on nodule size. Journal of internal medicine. 2002; 251; 5: 407-414