The Effect of Breast Cancer History on Bone Mineral Density in the Treatment of Postmenopausal Osteoporosis: One-Year Follow-Up Results

Yasemin Tombak 1 * , Ebru Karaca Umay 1, Fatma Nazli Unkazan 2, Ozgur Zeliha Karaahmet 1, Methiye Kubra Sezer 1, Ece Unlu Akyuz 1, Eda Gurcay 3
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1 Physical Medicine and Rehabilitation, Ankara Etlik City Hospital, Ankara, Turkey
2 Physical Medicine and Rehabilitation, Kirklareli University Faculty of Medicine, Kirklareli, Turkey
3 Physical Medicine and Rehabilitation, University of Health Sciences, Gaziler Physical and Rehabilitation Medicine Education and Research Hospital, Ankara, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 6, pp. 85-90. https://doi.org/10.23950/jcmk/15703
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Author Contributions: Conceptualization, Y.T., E.K.U.; drafting or revising critically, Y.T., E.K.U., E.U.A., E.G.; data collection or processing, E.K.U., F.N.U., M.K.S.; analysis or interpretation, Y.T., E.K.U., F.N.U., O.Z.K.; literature search, Y.T., E.K.U.; writing, Y.T., O.Z.K., E.U.A., E.G.; supervision: Y.T., E.K.U. All authors have read and agreed to the final version of the manuscript.

Ethics approval: The study protocol received institutional review board approval (dated 31.03.2023; Protocol No. P202300018) and all participants provided informed consent in the format required by the clinical research ethics committee of Kirklareli University, Kirklareli, Turkey.

Informed consent: All participants provided written informed consent in the format required by the clinical research ethics committee of the local institute.

Availability of data and material: The authors confirm that the data supporting the findings of this study are available within the article. The data associated with the paper are not publicly available but are available from the corresponding author on reasonable request.

ABSTRACT

Aim: Breast cancer patients who get certain chemotherapeutic agents are more likely to experience early menopause and to suffer osteoporotic fractures at a younger age. This study investigated the impact of breast cancer history on bone mineral density (BMD) levels in postmenopausal osteoporosis (OP) treatment.
Materials and Methods: This is a retrospective case-control study analyzed 65 female cases diagnosed with OP, including 32 patients with stable breast cancer who had undergone chemotherapy and/or radiotherapy but not within the last 5 years, and 33 matched controls. Demographic characteristics, total lumbar and femoral neck BMD levels and biochemical parameters were recorded for both groups.
Results: Before treatment, femoral neck T-score and serum Ca levels were lower in the patient group than in the control group (p=0.038, p=0.007, respectively). There was no difference between groups for the first year (p>0.05), but when the change within a group was examined, only the patient group showed a significant increase in femoral neck T-score and serum Ca levels (p=0.027, p=0.001, respectively). Patients who received radiotherapy had lower femoral neck BMD levels before and after treatment than those who did not receive radiotherapy (p=0.021, p=0.024, respectively), and the post-treatment recovery was not different (p>0.05).
Conclusion: This study demonstrated the success of osteoporosis treatment in patients with a previous diagnosis of breast cancer. Patients with breast cancer must be screened for osteoporosis and treated accordingly.
Keywords: bone mineral density, breast cancer, osteoporotic fractures, postmenopausal osteoporosis, screening

CITATION

Tombak Y, Karaca Umay E, Unkazan FN, Karaahmet OZ, Sezer MK, Unlu Akyuz E, et al. The Effect of Breast Cancer History on Bone Mineral Density in the Treatment of Postmenopausal Osteoporosis: One-Year Follow-Up Results. J CLIN MED KAZ. 2024;21(6):85-90. https://doi.org/10.23950/jcmk/15703

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