The Effect of Calcium on Premenstrual Syndrome: A Meta-Analysis Study

Kevser İlçioğlu 1, Bilge Nur Yıldırım Bayraktar 2 * , Ahsen Demirhan Kayacık 1
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1 Department of Nursing, Faculty of Health Sciences, Sakarya University, Sakarya, Türkiye
2 Institute of Health Sciences, Sakarya University, Sakarya, Türkiye
* Corresponding Author
J CLIN MED KAZ, In press. https://doi.org/10.23950/jcmk/15827
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Author Contributions: Conceptualization, K. I., B. N. Y. B. and A. D. K.; methodology, K. I., B. N. Y. B. and A. D. K.; validation, not applicable; formal analysis, K. I.; investigation, B. N. Y. B. and A. D. K.; resources, not applicable; data curation, not applicable; writing – original draft preparation, B. N. Y. B. and A. D. K.; writing – review and editing, K. I.; visualization, K. I.; supervision, K. I.; project administration, not applicable; funding acquisition, not applicable. All authors have read and agreed to the published version of the manuscript.

Data availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.

Human and animal rights: This article does not contain any studies with human or animals participants performed by any of the authors.

ABSTRACT

Aims
This study systematically reviewed the available randomised controlled trials to elucidate the general relationship between calcium and PMS.
Material and Methods
Meta-analysis followed PRISMA guidelines using the PICOS format, considering CONSORT recommendations. Searches were performed in PubMed, Web of Science, Google Scholar, and Scopus databases between 02.11.2022- 02.12.2022 using the keywords "premenstrual syndrome and calcium" and "premenstrual tension and calcium" and "premenstrual dysphoric disorder and calcium".
Results
This systematic review and meta-analysis included six randomised controlled trials published between 2013 and 2020. According to the pooled results of the six studies, calcium reduced the severity of PMS complaints (p=0.002; I2 = 76.2%) when calcium administration was compared with the control group for the reduction of PMS complaints. On the other hand, the severity of PMS complaints did not change when calcium administration for the reduction of PMS complaints was compared with other treatments (p=0.416; I2 = 54.7%).
Conclusions
This study showed that calcium effectively reduced the severity of PMS complaints compared to the control groups. In contrast, the severity of PMS complaints did not change when other treatments and calcium administration were compared.
Keywords: PMS, calcium, randomized controlled, meta-analysis.

CITATION

İlçioğlu K, Yıldırım Bayraktar BN, Demirhan Kayacık A. The Effect of Calcium on Premenstrual Syndrome: A Meta-Analysis Study. J Clin Med Kaz. 2025. https://doi.org/10.23950/jcmk/15827

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