The effect of corticosteroid use in septic shock on secondary infection frequency, microorganism species, morbidity, and mortality

Duygu Kayar Calili 1 * , Seval Izdes 1, Levent Ozturk 1
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1 Department of Anesthesiology and Reanimation, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 20, Issue 5, pp. 9-16. https://doi.org/10.23950/jcmk/13690
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ABSTRACT

Aim: We aimed to examine the effect of corticosteroid treatment in vasopressor-refractory septic shock on secondary infections, microorganism species, survival, and length of hospital stay.
Material and methods: In this observational study, the records of 108 septic shock patients admitted to the intensive care unit (ICU) were reviewed. Patients were divided into two groups: the corticosteroid group (Group S, n=60) and the non-corticosteroid group (Group S-0, n=48). The results of three cultures [blood, endotracheal aspirate (eta), urine, wound] taken after ICU admission were recorded. The groups were compared in terms of demographic characteristics, culture growth rates and microorganisms, length of hospital stay, and survival rates.
Results: The hospital (p=0.043) and ICU stay (p=0.035) were longer in Group S. There was no significant difference between the groups in terms of survival (p>0.05). The growth rate of the first urine culture was significantly higher in Group S-0 than in Group S (p=0.018), but there was no difference in terms of microorganism species (p>0.05). There was no significant difference in growth rates and microorganism species in blood, eta and wound cultures (p>0.05), but increase in growth rates were observed in the 2nd and 3rd eta and, wound cultures compared to first culture in Group S (p<0.05).
Conclusion: There was no difference between the patients who received and did not receive corticosteroid treatment in septic shock in terms of culture growth rates, growing microorganism species and mortality; however, the frequency of growth in eta and wound cultures increased and the length of hospital stay was longer in patients who received corticosteroids.
Keywords: Septic shock, corticosteroid, secondary infection, mortality, morbidity

CITATION

Calili DK, Izdes S, Ozturk L. The effect of corticosteroid use in septic shock on secondary infection frequency, microorganism species, morbidity, and mortality. J CLIN MED KAZ. 2023;20(5):9-16. https://doi.org/10.23950/jcmk/13690

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