The effect of inflammatory markers on the CORADS degree and the effects of treatments on RT-PCR test results in COVID-19
Hatice Hamarat 1 * ,
Özge Alkan Tali 1,
Berrin Yalınbaş Kaya 2,
Aral Karabağ 3,
Rabiye Altınbaş 4 More Detail
1 Internal Medicine Department, Eskişehir City Hospital, Eskişehir, Turkey
2 Gastroenterology Department, Eskişehir City Hospital, Eskişehir, Turkey
3 Radiology Department, Eskişehir City Hospital, Eskişehir, Turkey
4 Microbiology Department, Eskişehir City Hospital, Eskişehir,
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 5, pp. 42-47.
https://doi.org/10.23950/jcmk/12524
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ABSTRACT
Objective: There is still no diagnosis method with high sensitivity and specificity for COVID-19. Patient complaints, real-time reverse transcription-polymerase chain reaction (RT-PCR), inflammatory markers, clinical prognosis, and the degree of involvement in the chest CT, if necessary are evaluated in an effort to make a diagnosis. Delays in diagnosis have led to a rapid spread of the disease. This study aims to evaluate the effectiveness of the inflammatory markers and to determine the follow-up process of the patients by assessing the impact of the treatments administered on RT-PCR test results.
Material and methods: Files of 150 patients monitored in the wards with suspected COVID-19 are analyzed retrospectively. Patients were selected among those who underwent laboratory tests, RT-PCR testing and Thoracic CT within the first 24 hours of admission. Patients were divided into 5 groups based on the severity of involvement in Thoracic CT. Inflammatory markers were compared among the groups. Impact of the administered treatments on follow-up RT-PCR test results was evaluated.
Results: Studied inflammatory markers were in normal ranges and similar across all CORADS groups. Only the C-Reactive Protein (CRP) and Ferritin levels were showing an increase in accordance with CORADS severity. Mean time to testing negative on RT-PCR was 10 days across all treatment groups. Times to testing negative among patients receiving other treatments were similar.
Conclusion: Among the inflammatory markers, CRP and Ferritin values are correlated with CORADS severity. Administered COVID-19 treatments have similar impact on RT-PCR test results.
CITATION
Hamarat H, Tali ÖA, Kaya BY, Karabağ A, Altınbaş R. The effect of inflammatory markers on the CORADS degree and the effects of treatments on RT-PCR test results in COVID-19. J CLIN MED KAZ. 2022;19(5):42-7.
https://doi.org/10.23950/jcmk/12524
REFERENCES
- Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N, et al. Chest CT findings in coronavirus disease-19 (COVID-19): Relationship to duration of infection. Radiology. 2020. https://doi.org/10.1148/radiol.2020200463
- Organization, W. H. Coronavirus disease 2019 (COVID-19): situation report, 92 (2020).
- Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S et al. Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA internal medicine. 2020; 180 (7):934–943. https://doi.org/10.1001/jamainternmed.2020.0994
- Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; 395 (10229):1054–1062. https://doi.org/10.1016/S01406736(20)30566-3
- Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Eurosurveillance. 2020; 25(3): 2000045. https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045
- Rubin EJ, Baden LR, Morrissey S, Campion EW. Medical journals and the 2019-nCoV outbreak. N. Engl. J. Med. 2020; 382:10–15. https://doi.org/10.1056/NEJMe2024117
- Loeffelholz MJ, Tang YW. Laboratory diagnosis of emerging human coronavirus infections–the state of the art. Emerg. Microbes. Infect. 2020;9(1):747–756. https://doi.org/10.1080/22221751.2020.1745095
- Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens for COVID-19. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/lab/guidelines-clinical-specimens. html (accessed Sept 13, 2020).
- Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J. Chest CT for Typical Coronavirus Disease 2019 (COVID-19) Pneumonia: Relationship to Negative RT-PCR Testing. Radiology. 2020; 296(2):E41–e45. https://doi.org/10.1148/radiol.2020200343
- Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J,et al. Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. 2020 https://doi.org/10.1001/jama.2020.3204
- Vrishali S. Salian, Jessica A. Wright, Peter T. Vedell, Sanjana Nair, Chenxu Li, Mahathi Kandimalla,et al.COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies. Mol Pharm. 2021. https://doi.org/10.1021/acs.molpharmaceut.0c00608
- Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. https://doi.org/10.1056/NEJMoa2001017
- WHO. Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance. Jan 11, 2020. https://www.who.int/internalpublications-detail/clinical-management-of-severe-acute-respiratoryinfection-when-novel-coronavirus-(ncov)-infection-is-suspected (accessed Jan 20, 2020.
- An JY, Unsdorfer KML, Weinreb JC. BI-RADS, C-RADS, CAD-RADS, LI-RADS, Lung-RADS, NI-RADS, O-RADS, PI-RADS, TI-RADS: Reporting and Data Systems. RadioGraphics. 2019;39(5):1435–1436. https://doi.org/10.1148/rg.2019190087
- Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, et al. Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases. Radiology. 2020. https://doi.org/10.1148/radiol.2020200642
- Bai HX, Hsieh B, Xiong Z, Halsey K, Choi JW, Linh Tran TM, et al. Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT. Radiology. 2020. https://doi.org/10.1148/radiol.2020200823
- Waller JV, Kaur P, Tucker A, Lin KK, Diaz MJ, Henry TS, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. American Journal of Roentgenology. 2020;215: 834-838. https://doi.org/10.2214/AJR.20.23418
- Yin S, Huang M, Li D, Tang N. Difference of coagulation features between severe pneumonia induced by SARS-CoV2 and non-SARS-CoV2. J Thromb Thrombolysis. 2020;1–4. https://doi.org/10.1007/s11239-020-02105-8
- Henry BM, Santos de Oliveira MH, Benoit S, Plebani M, Lippi G. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis. Clin Chem Lab Med. 2020; 58(7): 1021–1028. https://doi.org/10.1515/cclm-2020-0369
- Han H, Yang L, Liu R, Liu F, Wu KL, Li J, et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med. 2020;58(7):1116–1120. https://doi.org/10.1515/cclm-2020-0188
- Iba T, Levy JH, Levi M, Connors JM, Thachil J. Coagulopathy of coronavirus disease 2019. Crit Care Med. 2020;48(9):1358–1364. https://doi.org/10.1097/CCM.0000000000004458
- Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020;18(5):1023–1026. https://doi.org/10.1111/jth.14810
- Tang N, Bai H, Chen X, Gong J, Li D, Sun Z. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost. 2020;18(5):1094–1099. https://doi.org/10.1111/jth.14817
- Kollias A, Kyriakoulis KG, Dimakakos E, Poulakou G, Stergiou GS, Syrigos K. Thromboembolic risk and anticoagulant therapy in COVID-19 patients: emerging evidence and call for action. Br J Haematol. 2020;189(5):846–847. https://doi.org/10.1111/bjh
- Castaneda SL, Larragoiti NG, Mendez AC, Ayala KB, Vázquez GD, Medina AP, Chora-Hernandez LD, Martínez CA, Viveros-Sandoval ME. Inflammatory and Prothrombotic Biomarkers Associated With the Severity of COVID-19 Infection. Clin Appl Thromb Hemost. 2021 ; 27(9). https://doi.org/10.1177/1076029621999099