The Importance of Vitamin-D in Androgenic Alopecia and Telogen Effluvium

Роль витамина D при андрогенной и телогеновой алопеции
Gülbahar Saraç 1, Tuba Tülay Koca 2 *
More Detail
1 Department of Dermatology, Faculty of Medicine, İnonu University, Malatya, Turkey
2 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 4, Issue 50, pp. 26-29. https://doi.org/10.23950/1812-2892-JCMK-00601
OPEN ACCESS 5042 Views 3124 Downloads
Download Full Text (PDF)

ABSTRACT

Aim: Androgenic alopecia (AA) is defined as progressive miniaturization of scarless hair follicle prevailing among both male and female. Telogen effluvium (TE) is the most common hair loss form accompanying systemic diseases. It is aimed to determine the role of vitamine D, the significance of which has been increasing in recent years, in hair loss problem within the scope of this study. 
Methods: The patients who applied to Dermatology clinic with the complaint of hair loss and diagnosed androgenic alopecia and telogen effluvium by clinic examination between the years 2015-2016 were included into this study. The age, gender and 25’OHvitamin-D level of the patients were recorded retrospectively.
Results: One-hundred eighty seven (N=187) participants (140 female / 47 male) were included in this study. Fifty-eight (N=58) patients (28 female / 30 male) with androgenic alopecia diagnosis formed the first group; 71 patients (65 female / 6 male) with telogen effluvium were formed the second group and 58 healthy volunteers (47 female / 11male) were included in the control group. When Vitamin-D level of first group (AA) was compared with that of the second group (TE) and the control group, there was a statistically significant difference observed (p=0.01/p=0.01 respectively). However, there was no statistically significant difference between the vitamin-D level of second group (TE) and that of the healthy control group (p=0.61).
Conclusion: The level of 25'(OH) vit D was found high in androgenic alopecia group than telogen effluvium and controls. Revealing the relationship between vitamin-D level and hair loss might give us the opportunity to come up with new treatment options considering refractory patients.
Keywords: vitamin D, telogen effluvium, androgenic alopecia

CITATION

Saraç G, Koca TT. The Importance of Vitamin-D in Androgenic Alopecia and Telogen Effluvium. Journal of Clinical Medicine of Kazakhstan. 2018;4(50):26-9. https://doi.org/10.23950/1812-2892-JCMK-00601

REFERENCES

  • Herskovitz I, Tosti A. Female Pattern Hair Loss. Int J Endocrinol Metab. 2013; 11:9860. https://doi.org/10.5812/ijem.9860
  • Dawber RPR, Ebling FJG, Wojnarowska FT. Disorders of hair. Textbook of dermatology. Ed. Champion RH, Burton JL, Ebling FJG. 5. Eddition. Oxford, Blackwell ScientificPubl, 1992; 2533-638.
  • Lolli F, Pallotti F, Rossi A, Fortuna MC, Caro G, Lenzi A, Sansone A, Lombardo F. Androgenetic alopecia: a review. Endocrine. 2017; 57(1):9-17. https://doi.org/10.1007/s12020-017-1280-y
  • Hillmer AM, Hanneken S, Ritzmann S, Becker T, Freudenberg J, Brockschmidt FF, et al. Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia. Am J Hum Genet. 2005; 77(1):140-8. https://doi.org/10.1086/431425
  • Kelly Y, Blanco A, Tosti A. Androgenetic Alopecia: An Update of Treatment Options. Drugs. 2016; 76(14):1349-64. https://doi. org/10.1007/s40265-016-0629-5
  • Saitoh M, Uzuka M, Sakamoto M. Human haircycle. J Invest Dermatol. 1970; 54:65-81. https://doi.org/10.1111/1523-1747. ep12551679
  • Malkud S. Telogen Effluvium: A Review. J Clin Diagn Res. 2015; 9(9):WE01-3. https://doi.org/10.7860/JCDR/2015/15219.6492
  • Grover C, Khurana A. Telogen effluvium. Indian J Dermatol Venereol Leprol. 2013; 79(5):591-603. https://doi.org/10.4103/0378- 6323.116731
  • Rebora A. Intermittent Chronic Telogen Effluvium. Skin Appendage Disord. 2017; 3(1):36-38. https://doi.org/10.1159/000455882
  • Gerkowicz A, Chyl-Surdacka K, Krasowska D, Chodorowska G. The Role of Vitamin D in Non-Scarring Alopecia. Int J Mol Sci. 2017; 18(12):E2653. https://doi.org/10.3390/ijms18122653
  • Cash TF: The psychosocial consequences of androgenic alopecia: a review of the research literature. Br J Dermatol. 1999; 141:398-405. https://doi.org/10.1046/j.1365-2133.1999.03030.x
  • Kutlubay Z, Bağlam S, Engin B, Serdaroğlu S. Erkeklerde androgenetik alopesi. Türkderm. 2014; 48:36-9.
  • Hamilton JB: Male hormone stimulation is prerequisite and an incitant in common baldness. Am J Anat. 1942; 71:451-80. https:// doi.org/10.1002/aja.1000710306
  • Headington JT. Telogen effluvium. New concepts and review. Arch Dermatol. 1993; 129(3):356-363. https://doi.org/10.1001/archderm.1993.01680240096017
  • Whiting DA. Chronic telogen effluvium: increased scalp hair shedding in middle-aged female. J Am Acad Dermatol. 1996; 35(6):899- 906. https://doi.org/10.1016/S0190-9622(96)90113-9
  • Myszka M, Klinger M. The immuno modulatory role of Vitamin D. Postepy Hig Med Dosw (Online). 2014;68:865-78 https:// doi.org/10.5604/17322693.1110168
  • Morimoto S, Kumahara Y. A patient with psoriasis cured by 1 alpha-hydroxy VitD3. Med J Osaka Univ 1985;35:51-4
  • Parsad D, Saini R, Nagpal R. Calcipotriol in vitiligo: a preliminary study. Pediatr Dermatol. 1999; 16:317-20. https://doi.org/10.1046/j.1525-1470.1999.00083.x
  • Cunningham BB, Landells ID, Langman C, Sailer DE, Paller AS. Topical calcipotriene for morphea/linearscleroderma. J Am Acad Dermatol. 1998; 39:211-36. https://doi.org/10.1016/S0190-9622(98)70077-5
  • Wegienka G, Havstad S, Zoratti EM, Kim H, Ownby DR, Johnson C C. Association between vitamin D levels and allergy-related outcomes vary by race and other factors. J Allergy Clin Immunol. 2015;136(5):1309-14. https://doi.org/10.1016/j.jaci.2015.04.017
  • Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy. 2015; 45(1):114-25. https://doi.org/10.1111/cea.12430
  • Sakai Y, Kishimoto J, Demay MB: Metabolic and cellular analysis of alopecia in vitamin D receptor knock out mice. J ClinInvest. 2001; 107:961- 6. https://doi.org/10.1172/JCI11676
  • Mady LJ, Ajibade DV, Hsaio C, Teichert A, Fong C, Wang Y, et al. The Transient Role for Calcium and Vitamin D during the Developmaletal Hair Follicle Cycle. J Invest Dermatol. 2016; 16: S0022-202X(16)30876-4. https://doi.org/10.1016/j.jid.2016.02.813
  • Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, et al. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002;118(1):11-6. https://doi.org/10.1046/j.1523-1747.2002.01644.x
  • Beer S, Tieder M, Kohelet D, et al: Vitamin D resistant rickets with alopecia: A form of end organ resistanceto 1,25 dihydroxy vitamin D. Clin Endocrinol. 1981; 14:395-402. https://doi.org/10.1111/j.1365-2265.1981.tb00626.x
  • Mahamid M, Abu-Elhija O, Samamra M, Mahamid A, Nseir W. Association between vitamin D levels and alopecia areata. Isr Med Assoc J. 2014; 16(6):367-70.
  • Fawzi MM, Mahmoud SB, Ahmed SF, Shaker OG. Assessmalet of vitamin D receptors in alopecia areata and androgenic alopecia. J Cosmet Dermatol. 2016; https://doi.org/10.1111/jocd.12224
  • H. Rasheed a D. Mahgoub a R. Hegazy a M. El-Komy a R. Abdel Hay a M.A. Hamid a E. et al. Serum Ferritinand Vitamin D in Female Hair Loss: Do They Play a Role? Skin Pharmacol Physiol. 2013; 26:101–107.https://doi.org/10.1159/000346698