The role of regulatory autoantibodies in prediction of obstetric hemorrhage

Роль определения регуляторных аутоантител в прогнозировании акушерских кровотечений
Gauri Bapayeva 1, Saltanat Kulbayeva 2
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1 National Research Center for Maternal and Child Health, Astana, Kazakhstan
2 South Kazakhstan State Pharmaceutical Academy, Shymkent, Kazakhstan
J CLIN MED KAZ, Volume 1, Issue 35, pp. 34-39.
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ABSTRACT

The aim: to evaluate the prognostic valueof regulatory autoantibodies for prediction of obstetric hemorrhage
Materials and methods:126 pregnant women have been examined, i.e. 96 pregnant women of haemorrhage risk group and 30 pregnant women with physiologic gestation and childbirth course. Pregnant women of risk group have been divided into 2 groups depending on outcome of childbirth: basic and comparative groups. Basic group included 65 women, who had postpartum haemorrhageand comparative group included 31 women of risk group without postpartum haemorrhage. The level of regulatory autoantibodies in blood serum of all pregnant women was determined in 3rd trimester of pregnancy using the enzyme-linked immunosorbent assay technology.
Results: The greatest predictive importance definition of the regulatory possesses autoantibodies to DNA, TrM-03 and ANCA, and also average immunological reactivity (transgression coefficient – 44,64%, 11,86%, 14,41% and 40,51% respectively).
Conclusion:Thedeterminationof regulatory autoantibodiesin the bloodof pregnant womenin the 3rdtrimester has high predictive value(82%).
Keywords: autoantibodies, postpartum haemorrhage, the risk factors, prediction

CITATION

Bapayeva G, Kulbayeva S. The role of regulatory autoantibodies in prediction of obstetric hemorrhage. Journal of Clinical Medicine of Kazakhstan. 2015;1(35):34-9.

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