The role of sentinel lymph nodes in breast cancer. The current state of the problem.

Роль сигнальных лимфатических узлов при раке молочной железы. Современное состояние проблемы.
Aliya Yermagambetova 1, Abay Makishev 1, Khalel Imanbayev 1
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1 Department of Oncology, JSC “Medical University of Astana”, Astana, Kazakhstan
J CLIN MED KAZ, Volume 2, Issue 44, pp. 15-18. https://doi.org/10.23950/1812-2892-JCMK-00444
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ABSTRACT

Sentinel lymph nodes (SLN) biopsy is currently the standard procedure for axillary staging in patients with invasive breast cancer and clinically negative lymph nodes (cN0). Historically, all patients with a positive sentinel lymph node (SLN) undergo classical axillary lymph node dissection (ALND). A randomized clinical trial in patients with breast cancer with clinical T1-2N0M0, with positive SLN afterwards undergo classical ALND showed that women diagnosed with T1-T2 and cN0 who underwent breast-conserving surgery and radiation therapy can safely avoid ALND. The main goal of SLN examination should be the detection of all macrometastases (> 2 mm). The role and timing of SLN in patients who received neoadjuvant polychemotherapy is still controversial and continues being studied in clinical trials.
Keywords: breast cancer, sentinel lymph node, axillary lymphadenectomy

CITATION

Yermagambetova A, Makishev A, Imanbayev K. The role of sentinel lymph nodes in breast cancer. The current state of the problem.. Journal of Clinical Medicine of Kazakhstan. 2017;2(44):15-8. https://doi.org/10.23950/1812-2892-JCMK-00444

REFERENCES

  • Krag DN, Anderson SJ, Julian TB et al. Sentinel-lymph-node resection compared with conventional axillary-lymphnode dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010; 11; 927–933.
  • Canavese G, Catturich A, Vecchio C et al. Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial. Ann. Oncol. 2009; 20; 1001–1007.
  • Albertini JJ, Lyman GH, Cox C et al. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA 1996; 276; 1818–1822.
  • Borgstein PJ, Pijpers R, Comans EF, van Diest PJ, Boom RP, Meijer S. Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probe detection. J. Am. Coll. Surg. 1998; 186; 275–283.
  • Giuliano AE, Jones RC, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer. J. Clin. Oncol. 1997; 15; 2345–2350.
  • Giuliano AE, Kirgan DM, Guenther JM, Morton DL. Lymphatic mapping and sentinel lymphadenectomy for breast cancer. Ann. Surg. 1994; 220; 391–398; discussion 398–401.
  • Bilimoria KY, Bentrem DJ, Hansen NM et al. Comparison of sentinel lymph node biopsy alone and completion axillary lymph node dissection for node-positive breast cancer. J. Clin. Oncol. 2009; 27; 2946–2953.
  • Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis. Cancer. 2006; 106; 4–16.
  • Galimberti V, Cole BF, Zurrida S et al. Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol. 2013; 14; 297–305.
  • Donker M, van Tienhoven G, Straver ME et al. Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial. Lancet Oncol. 2014; 15; 1303–1310.
  • Lyman GH, Temin S, Edge SB et al. Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update. J. Clin. Oncol. 2014; 32; 1365–1383.
  • Coates AS, Winer EP, Goldhirsch A et al. Tailoring therapies – improving the management of early breast cancer: St Gallen international expert consensus on the primary therapy of early breast cancer 2015. Ann. Oncol. 2015; 26; 1533–1546.
  • National Institute for Health and Care Excellence. Early and locally advanced breast cancer diagnosis and treatment. Clinical guideline 80. London: NICE, 2009.
  • Association of Breast Surgery. Consensus statement on management of the malignant axilla in early breast cancer. 2015.
  • Brogi E, Torres-Matundan E, Tan LK, Cody HS 3rd. The results of frozen section, touch preparation, and cytological smear are comparable for intraoperative examination of sentinel lymph nodes: a study in 133 breast cancer patients. Ann. Surg. Oncol. 2005; 12; 173–180.
  • Lu Q, Tan EY, Ho B et al. Achieving breast cancer surgery in a single setting with intraoperative frozen section analysis of the sentinel lymph node. Clin. Breast Cancer. 2013; 13; 140– 145.
  • Liu LC, Lang JE, Lu Y et al. Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a metaanalysis and single-institution experience. Cancer. 2011; 117; 250–258.
  • Wong J, Yong WS, Thike AA et al. False negative rate for intraoperative sentinel lymph node frozen section in patients with breast cancer: a retrospective analysis of patients in a single Asian institution. J. Clin. Pathol. 2015; 68; 536–540.